TNFRSF10A and DAP3

Number of citations of the paper that reports this interaction (PMID 11376335)
15

Data Source:
HPRD (two hybrid, in vivo)

		TNFRSF10A	DAP3
Gene Name		tumor necrosis factor receptor superfamily, member 10a	death associated protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Nucleolus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Ribosome Small Ribosomal Subunit
	Molecular Function	Protease Binding Receptor Activity Death Receptor Activity Protein Binding Transcription Factor Binding TRAIL Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors TRAIL-activated Apoptotic Signaling Pathway Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Organelle Organization Apoptotic Mitochondrial Changes Mitochondrial Translation Mitochondrial Translational Initiation Mitochondrial Translational Elongation Mitochondrial Translational Termination Apoptotic Signaling Pathway
Pathways		Regulation by c-FLIP Death Receptor Signalling TRAIL signaling Dimerization of procaspase-8 Caspase-8 activation by cleavage Programmed Cell Death Extrinsic Pathway	Mitochondrial translation Organelle biogenesis and maintenance Mitochondrial translation elongation Mitochondrial translation initiation Mitochondrial translation termination
Drugs
Diseases
GWAS		Age-related macular degeneration ( 21909106 23455636) Attention deficit hyperactivity disorder ( 20732625)
Protein-Protein Interactions		15 interactors: BCL10 BTK CASP8 CD4 COL2A1 DAP3 FADD MADD MOAP1 RASSF1 RIPK1 TNFRSF10B TNFRSF10D TNFSF10 TRADD	13 interactors: AHR AR ESR1 ESR2 FADD HIF1A HSP90AA1 NR3C1 PGR PPARA THRA TNFRSF10A TNFRSF25
Entrez ID		8797	7818
HPRD ID		04679	03646
Ensembl ID			ENSG00000132676
Uniprot IDs		O00220	P51398
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Extrinsic Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Regulation Of Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway Zymogen Activation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Protein Processing Cellular Response To Stimulus Toll-like Receptor Signaling Pathway Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Signaling Cell Communication Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Macrophage Differentiation Regulation Of Signal Transduction Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity Regulation Of Proteolysis	Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Gland Development Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Cyclic Compound Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Lipid Response To Steroid Hormone Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Signal Transduction Cellular Response To Hormone Stimulus Signaling Positive Regulation Of Macromolecule Biosynthetic Process Cell Communication Positive Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Metabolic Process Response To Organic Substance Prostate Gland Development Cellular Response To Organic Substance Cellular Response To Stimulus Reproductive Process Response To Lipid Reproductive Structure Development Response To Organic Cyclic Compound Reproductive System Development Epithelial Cell Maturation Mammary Gland Epithelium Development Regulation Of Apoptotic Process Response To Hormone Organ Development System Development Organ Morphogenesis Transcription, DNA-templated Rhythmic Process RNA Biosynthetic Process Epithelium Development TRAIL-activated Apoptotic Signaling Pathway Response To Stimulus Developmental Process Involved In Reproduction Multicellular Organismal Development Regulation Of Nitric-oxide Synthase Activity
Tagcloud ?		aa activator atm atmmutated b bax cdkn1a cll combinations elicit harboring hot lymphocytic maintained mdm2 next notch1 notch1mutated notch1mutations notch2 nutlin showing spot subgroup subset surprisingly tp53 tp53mutated	biogenesis constituent coregulated ctf1 elk1 elk4 esrra exploring gabpa gtp hdap3 homoeostasis hox11 microarray mitochondrial nrf oncocytic pparg presenting publicly ribosome runx1 rxra silico tal1 ternary tumourigenesis tumours upregulated
Tagcloud (Difference) ?		aa activator atm atmmutated b bax cdkn1a cll combinations elicit harboring hot lymphocytic maintained mdm2 next notch1 notch1mutated notch1mutations notch2 nutlin showing spot subgroup subset surprisingly tp53 tp53mutated	biogenesis constituent coregulated ctf1 elk1 elk4 esrra exploring gabpa gtp hdap3 homoeostasis hox11 microarray mitochondrial nrf oncocytic pparg presenting publicly ribosome runx1 rxra silico tal1 ternary tumourigenesis tumours upregulated
Tagcloud (Intersection) ?