TNFRSF10A

Description		TNF receptor superfamily member 10a
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Surface Membrane Plasma Membrane Raft Membrane Raft
	Molecular Function	Protease Binding Death Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding TRAIL Binding
	Biological Process	Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Extrinsic Apoptotic Signaling Pathway
Pathways		Caspase activation via Death Receptors in the presence of ligand Cell surface interactions at the vascular wall Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 TRAIL signaling
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 21909106 23455636) Attention deficit hyperactivity disorder ( 20732625) Central serous retinopathy ( 31872073) Early age-related macular degeneration ( 32843070)
Interacting Genes		15 interacting genes: BCL10 BTK CASP8 CD4 COL2A1 DAP3 FADD MADD MOAP1 RASSF1 RIPK1 TNFRSF10B TNFRSF10D TNFSF10 TRADD
Entrez ID		8797
HPRD ID		04679
Ensembl ID		ENSG00000104689
Uniprot IDs		O00220
PDB IDs		5CIR
Enriched GO Terms of Interacting Partners?		Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Death-inducing Signaling Complex Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Signal Transduction Death Receptor Binding Cell Surface Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process TRAIL Binding Positive Regulation Of Programmed Cell Death Ripoptosome Positive Regulation Of Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Myeloid Leukocyte Differentiation Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macrophage Differentiation Cellular Response To Mechanical Stimulus Positive Regulation Of Leukocyte Differentiation Negative Regulation Of Necroptotic Process Regulation Of Apoptotic Signaling Pathway Signaling Adaptor Activity Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Macrophage Differentiation Positive Regulation Of Defense Response Positive Regulation Of Myeloid Cell Differentiation Death Domain Binding Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Protein Metabolic Process Regulation Of Necroptotic Process Tumor Necrosis Factor Receptor Binding Positive Regulation Of Cytokine Production Regulation Of Signal Transduction Regulation Of Myeloid Leukocyte Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Death Effector Domain Binding Regulation Of Programmed Necrotic Cell Death
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