RIOK3 and CASP10

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (affinity chromatography technology, two hybrid)

		RIOK3	CASP10
Name		RIO kinase 3	caspase 10
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Preribosome, Small Subunit Precursor	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Caspase Binding Protein Serine Kinase Activity	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Death Effector Domain Binding
	Biological Process	Immune System Process Chromosome Segregation Maturation Of SSU-rRNA Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Interferon-beta Production Negative Regulation Of MDA-5 Signaling Pathway Ribosome Biogenesis Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus Cellular Response To DsRNA Cellular Response To Virus Cellular Response To DsDNA	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Protein Maturation Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Drugs		Fostamatinib	None
Diseases		None	Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Anthropometric traits ( 30166351 ) Anthropometric traits (multi-trait analysis) ( 30166351 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Poultry consumption ( 32066663 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Spontaneous preterm birth without premature rupture of membranes ( 31194736 ) Waist circumference adjusted for body mass index ( 34021172 )	Alanine aminotransferase levels ( 33547301 ) Basal cell carcinoma ( 25855136 ) Chronic lymphocytic leukemia ( 23770605 28165464 ) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831 ) Mean corpuscular hemoglobin ( 32888494 )
Novel Interactors		None recorded	6 novel interactors: BMPR2 ERBB4 IGFBP2 NPTX1 SCARB1 YBX3
Interacting Genes		9 interacting genes: BCL2L11 CASP10 CDC42 CREB3L3 FBXO25 PAK2 SMURF1 TULP3 UBC	30 interacting genes: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP
Entrez ID		8780	843
HPRD ID		04659	03458
Ensembl ID		ENSG00000101782	ENSG00000003400
Uniprot IDs		B0YJ89 B4E1Q4 O14730	A0A0S2Z3G5 A0A0S2Z3Z5 Q92851
PDB IDs		8ZDB 8ZDC 8ZDD	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Execution Phase Of Apoptosis Execution Phase Of Apoptosis Wnt Signaling Pathway, Planar Cell Polarity Pathway Adherens Junction Organization Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Neuron Apoptotic Process BIM-BCL-2 Complex BIM-BCL-xl Complex Engulfment Of Target By Autophagosome	Cell Death Programmed Cell Death Apoptotic Process Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cysteine-type Peptidase Activity Death Receptor Binding Extrinsic Apoptotic Signaling Pathway Protein Processing Pyroptotic Inflammatory Response Death-inducing Signaling Complex Regulation Of Canonical NF-kappaB Signal Transduction Execution Phase Of Apoptosis Regulation Of Neuron Apoptotic Process Neuron Apoptotic Process Regulation Of Necroptotic Process Cellular Response To Mechanical Stimulus Protein Maturation Regulation Of Programmed Necrotic Cell Death Cell Surface Receptor Signaling Pathway Peptidase Activity Cellular Response To Staurosporine Proteolysis Epithelial Cell Apoptotic Process Regulation Of Signal Transduction Glial Cell Apoptotic Process Positive Regulation Of Execution Phase Of Apoptosis Response To Mechanical Stimulus Response To Anesthetic Ripoptosome CD95 Death-inducing Signaling Complex Response To Lipopolysaccharide Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Defense Response Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Response To Stress Regulation Of Defense Response Regulation Of Intracellular Signal Transduction Response To Cobalt Ion Regulation Of Apoptotic Signaling Pathway Fibroblast Apoptotic Process