RIOK3

Description		RIO kinase 3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Preribosome, Small Subunit Precursor
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Caspase Binding Protein Serine Kinase Activity
	Biological Process	Immune System Process Chromosome Segregation Maturation Of SSU-rRNA Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Interferon-beta Production Negative Regulation Of MDA-5 Signaling Pathway Ribosome Biogenesis Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus Cellular Response To DsRNA Cellular Response To Virus Cellular Response To DsDNA
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Fostamatinib
Diseases
GWAS		Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Poultry consumption ( 32066663) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		9 interacting genes: BCL2L11 CASP10 CDC42 CREB3L3 FBXO25 PAK2 SMURF1 TULP3 UBC
Entrez ID		8780
HPRD ID		04659
Ensembl ID		ENSG00000101782
Uniprot IDs		B0YJ89 B4E1Q4 O14730
PDB IDs		8ZDB 8ZDC 8ZDD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Execution Phase Of Apoptosis Execution Phase Of Apoptosis Wnt Signaling Pathway, Planar Cell Polarity Pathway Adherens Junction Organization Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Neuron Apoptotic Process BIM-BCL-2 Complex BIM-BCL-xl Complex Engulfment Of Target By Autophagosome
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