GRIK5 and GPAA1

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		GRIK5	GPAA1
Name		glutamate ionotropic receptor kainate type subunit 5	glycosylphosphatidylinositol anchor attachment 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Plasma Membrane Membrane Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Membrane GPI-anchor Transamidase Complex
	Molecular Function	Glutamate-gated Receptor Activity Monoatomic Ion Channel Activity Ligand-gated Monoatomic Ion Channel Activity Kainate Selective Glutamate Receptor Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	GPI-anchor Transamidase Activity Protein Binding GPI Anchor Binding
	Biological Process	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Modulation Of Chemical Synaptic Transmission Excitatory Postsynaptic Potential Regulation Of Presynaptic Membrane Potential	GPI Anchor Biosynthetic Process Protein Retention In ER Lumen Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis
Pathways		Activation of Ca-permeable Kainate Receptor	Attachment of GPI anchor to uPAR
Drugs		Glutamic acid Butabarbital Topiramate	None
GWAS		Bipolar disorder ( 21771265 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lymphocyte count ( 32888494 ) Meat-related diet ( 32066663 )	Asthma ( 31959851 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Serum metabolite concentrations in chronic kidney disease ( 33838163 ) Serum metabolite levels ( 23093944 )
Novel Interactors		None recorded	9 novel interactors: ADAMDEC1 CACNG8 DGAT1 GIT1 LRRC14 LY6E NDRG1 TERF2IP TONSL
Interacting Genes		9 interacting genes: DLG4 GOLM1 GPAA1 GRID2 GRIK1 GRIK2 GRIK3 LRSAM1 MLF1	10 interacting genes: AGTR1 AQP2 EIF3E GNRHR GRIK5 PIGK PIGT PIGU PIN1 PRR13
Entrez ID		2901	8733
HPRD ID		02614	04334
Ensembl ID		ENSG00000105737	ENSG00000197858
Uniprot IDs		Q16478	O43292
PDB IDs		Not available	7W72 7WLD 8IMX 8IMY
GO Terms Enriched among Interactors		Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Glutamate Receptor Signaling Pathway Postsynaptic Density Membrane Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Glutamate-gated Calcium Ion Channel Activity Glutamate-gated Receptor Activity Glutamate Receptor Activity Postsynaptic Membrane Regulation Of Postsynaptic Membrane Potential Chemical Synaptic Transmission Dendrite Cytoplasm Trans-synaptic Signaling Synaptic Signaling Monoatomic Ion Channel Activity Regulation Of Membrane Potential Ionotropic Glutamate Receptor Complex Modulation Of Chemical Synaptic Transmission Scaffold Protein Binding Cell-cell Signaling Regulation Of Synaptic Transmission, Glutamatergic Signaling Receptor Activity Signaling PDZ Domain Binding Negative Regulation Of Synaptic Transmission, Glutamatergic Cell Communication Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Presynaptic Membrane Synapse Calcium-mediated Signaling Regulation Of Long-term Neuronal Synaptic Plasticity AMPA Glutamate Receptor Complex Regulation Of Presynaptic Membrane Potential Glutamatergic Synapse Regulation Of Synaptic Plasticity Negative Regulation Of Synaptic Transmission Terminal Bouton Modulation Of Excitatory Postsynaptic Potential Receptor Clustering Monoatomic Ion Transmembrane Transport Regulation Of Neuronal Synaptic Plasticity Excitatory Postsynaptic Potential P2Y1 Nucleotide Receptor Binding Mossy Fiber Rosette Detection Of Cold Stimulus Involved In Thermoception Extracellularly Glutamate-gated Ion Channel Activity	GPI-anchor Transamidase Complex GPI Anchored Protein Biosynthesis Attachment Of GPI Anchor To Protein GPI Anchor Binding GPI-anchor Transamidase Activity GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Glycerolipid Metabolic Process Phosphatidylinositol Metabolic Process Gamma-tubulin Binding Glycerophospholipid Biosynthetic Process Angiotensin Type I Receptor Activity Cis-trans Isomerase Activity Negative Regulation Of ARF Protein Signal Transduction Membrane Lipid Metabolic Process