GRIK5 and GRIK3

Number of citations: 0 (PubMedID 9466455)
Data Source: HPRD (in vivo)

		GRIK5	GRIK3
Name		glutamate ionotropic receptor kainate type subunit 5	glutamate ionotropic receptor kainate type subunit 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Plasma Membrane Membrane Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane	Plasma Membrane Membrane Axon Dendrite Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Glutamate-gated Receptor Activity Monoatomic Ion Channel Activity Ligand-gated Monoatomic Ion Channel Activity Kainate Selective Glutamate Receptor Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Glutamate-gated Receptor Activity Monoatomic Ion Channel Activity Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Kainate Selective Glutamate Receptor Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Modulation Of Chemical Synaptic Transmission Excitatory Postsynaptic Potential Regulation Of Presynaptic Membrane Potential	Monoatomic Ion Transport Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Regulation Of Presynaptic Membrane Potential
Pathways		Activation of Ca-permeable Kainate Receptor	Activation of Ca-permeable Kainate Receptor Presynaptic function of Kainate receptors
Drugs		Glutamic acid Butabarbital Topiramate	Glutamic acid Butabarbital Topiramate
GWAS		Bipolar disorder ( 21771265 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lymphocyte count ( 32888494 ) Meat-related diet ( 32066663 )	Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Forced expiratory volume in 1 second (environmental tobacco smoke interaction) ( 28738859 ) Iron status biomarkers (total iron binding capacity) ( 28334935 ) Iron status biomarkers (transferrin saturation) ( 28334935 ) Metabolite levels ( 23823483 ) Neuroticism ( 27067015 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Schizophrenia ( 23894747 )
Interacting Genes		9 interacting genes: DLG4 GOLM1 GPAA1 GRID2 GRIK1 GRIK2 GRIK3 LRSAM1 MLF1	4 interacting genes: FLNA GRIK1 GRIK4 GRIK5
Entrez ID		2901	2899
HPRD ID		02614	00691
Ensembl ID		ENSG00000105737	ENSG00000163873
Uniprot IDs		Q16478	Q13003
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Glutamate Receptor Signaling Pathway Postsynaptic Density Membrane Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Glutamate-gated Calcium Ion Channel Activity Glutamate-gated Receptor Activity Glutamate Receptor Activity Postsynaptic Membrane Regulation Of Postsynaptic Membrane Potential Chemical Synaptic Transmission Dendrite Cytoplasm Trans-synaptic Signaling Synaptic Signaling Monoatomic Ion Channel Activity Regulation Of Membrane Potential Ionotropic Glutamate Receptor Complex Modulation Of Chemical Synaptic Transmission Scaffold Protein Binding Cell-cell Signaling Regulation Of Synaptic Transmission, Glutamatergic Signaling Receptor Activity Signaling PDZ Domain Binding Negative Regulation Of Synaptic Transmission, Glutamatergic Cell Communication Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Presynaptic Membrane Synapse Calcium-mediated Signaling Regulation Of Long-term Neuronal Synaptic Plasticity AMPA Glutamate Receptor Complex Regulation Of Presynaptic Membrane Potential Glutamatergic Synapse Regulation Of Synaptic Plasticity Negative Regulation Of Synaptic Transmission Terminal Bouton Modulation Of Excitatory Postsynaptic Potential Receptor Clustering Monoatomic Ion Transmembrane Transport Regulation Of Neuronal Synaptic Plasticity Excitatory Postsynaptic Potential P2Y1 Nucleotide Receptor Binding Mossy Fiber Rosette Detection Of Cold Stimulus Involved In Thermoception Extracellularly Glutamate-gated Ion Channel Activity	Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Glutamate Receptor Signaling Pathway Regulation Of Membrane Potential Regulation Of Postsynaptic Membrane Potential Postsynaptic Density Membrane Glutamate-gated Receptor Activity Presynaptic Membrane Monoatomic Ion Transmembrane Transport Monoatomic Ion Channel Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Monoatomic Ion Transport Postsynaptic Membrane Signaling Receptor Activity Regulation Of Presynaptic Membrane Potential Transmembrane Transport Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Hippocampal Mossy Fiber To CA3 Synapse Modulation Of Chemical Synaptic Transmission Cell-cell Signaling Cell Surface Receptor Signaling Pathway Signaling Cell Communication Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Biological Quality Synapse Fc-gamma Receptor I Complex Binding Tubulin Deacetylation Myb Complex Formation Of Radial Glial Scaffolds Establishment Of Sertoli Cell Barrier Glycoprotein Ib-IX-V Complex Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Protein Localization To Bicellular Tight Junction Cell Projection Regulation Of Cell Communication Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Signaling Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Blood Coagulation, Intrinsic Pathway Regulation Of Membrane Repolarization During Action Potential Glutamate-gated Calcium Ion Channel Activity Negative Regulation Of Transcription By RNA Polymerase I