ADAM19 and SH3GL2

Number of citations of the paper that reports this interaction (PubMedID 10531379)
0

Data Source:
BioGRID (two hybrid)

		ADAM19	SH3GL2
Description		ADAM metallopeptidase domain 19	SH3 domain containing GRB2 like 2, endophilin A1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Membrane Extracellular Matrix	Golgi Membrane Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Cell Projection Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynapse Postsynapse Glutamatergic Synapse Presynaptic Cytosol
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Metal Ion Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Placenta Development Proteolysis Membrane Protein Ectodomain Proteolysis Positive Regulation Of Gene Expression Protein Processing Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Regulation Of Receptor Internalization Endocytosis Signal Transduction Central Nervous System Development Negative Regulation Of Gene Expression Neuron Projection Development Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Synaptic Vesicle Endocytosis Dendrite Extension Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Blood-brain Barrier Permeability Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Pathways		Invadopodia formation Regulation of CDH11 function	Retrograde neurotrophin signalling Retrograde neurotrophin signalling EGFR downregulation MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS		Asthma ( 31959851) Blood protein levels ( 30072576) Body mass index ( 28552196) Chronic obstructive pulmonary disease ( 33909500 28166215 30804561) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Inflammatory skin disease ( 25574825) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (adrenergics, inhalants) ( 31015401) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Peak expiratory flow ( 30804560) Pulmonary function ( 20010835) Pulmonary function (smoking interaction) ( 23284291) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577) Triglyceride levels ( 31647587)	Cerebral cortical growth ( 29682794) Cognitive performance ( 19734545) FEV1 ( 30804560) HDL cholesterol levels in HIV infection ( 33109212) Heart failure ( 20445134) Lung function (FVC) ( 30804560) Midgestational circulating levels of PBDEs ( 28235828) Multiple sclerosis ( 19010793) Myopia ( 27182965) Nontraumatic osteonecrosis of the femoral head ( 32701715) Obesity-related traits ( 23251661) Obsessive-compulsive traits ( 33531474) Parkinson's disease ( 22451204 32201043 28892059 27182965) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pursuit maintenance gain ( 29064472) Small cell lung carcinoma ( 28604730) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		8 interacting genes: A2M ABI2 COPB1 DYRK1A FURIN NRG1 SH3GL2 TNFSF11	53 interacting genes: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 FBXO32 FXR1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL3 SH3KBP1 SHANK3 SLC17A7 SYNJ1 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC
Entrez ID		8728	6456
HPRD ID		04704	05125
Ensembl ID		ENSG00000135074	ENSG00000107295
Uniprot IDs		Q8TBU7 Q9H013	Q99962
PDB IDs			1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?		Signaling Receptor Binding Negative Regulation Of Complement Activation, Lectin Pathway Serine-type Endopeptidase Inhibitor Activity Peptidyl-tyrosine Phosphorylation System Development Actin Filament Histone H3T45 Kinase Activity Regulation Of Receptor Internalization Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Zymogen Inhibition Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Zonula Adherens Assembly Stem Cell Differentiation Protease Binding Interleukin-8 Binding Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Receptor Catabolic Process Negative Regulation Of Blood-brain Barrier Permeability Positive Regulation Of Osteoclast Development Positive Regulation Of Corticotropin-releasing Hormone Secretion Tumor Necrosis Factor Binding Interleukin-1 Binding Extracellular Space Golgi Membrane Negative Regulation Of Heterochromatin Formation Nervous System Development Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Ventricular Cardiac Muscle Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway ErbB-3 Class Receptor Binding Receptor Ligand Activity Positive Regulation Of Protein Autophosphorylation Regulation Of MAPK Cascade ERBB2-ERBB4 Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Endocardial Cell Differentiation Nickel Cation Binding ERBB4-ERBB4 Signaling Pathway	Endocytosis Synapse Neuron Projection Import Into Cell SH3 Domain Binding Endosome Regulation Of Endocytosis Regulation Of Cellular Component Organization Synaptic Vesicle Endocytosis Vesicle Scission Presynaptic Endocytosis Modulation Of Excitatory Postsynaptic Potential Regulation Of Vesicle-mediated Transport Cytoplasmic Vesicle Glutamatergic Synapse Positive Regulation Of Immune System Process Regulation Of Synaptic Vesicle Endocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Growth Cone Clathrin-coated Pit Cell Junction Organization Presynapse Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Multicellular Organismal Process Regulation Of Synapse Structure Or Activity Maintenance Of Blood-brain Barrier Vesicle-mediated Transport Vesicle-mediated Transport In Synapse Clathrin Binding Receptor-mediated Endocytosis Axon Cerebellar Mossy Fiber Developmental Process Regulation Of Long-term Synaptic Potentiation Cellular Response To Manganese Ion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Membrane Potential Cell-cell Junction Early Endosome Regulation Of Nervous System Process Nuclear Envelope Lumen Cytoplasm Tight Junction Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation Tight Junction Organization Positive Regulation Of Neurogenesis Regulation Of Developmental Process Synaptic Vesicle
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