ADAM19 and NRG1

Number of citations: 0 (PubMedID 11116142)
Data Source: HPRD (in vitro)

		ADAM19	NRG1
Name		ADAM metallopeptidase domain 19	neuregulin 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Membrane Extracellular Matrix	Extracellular Region Extracellular Space Nucleus Nucleoplasm Plasma Membrane Membrane Apical Plasma Membrane Glutamatergic Synapse
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Metal Ion Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process	Transcription Coregulator Activity Signaling Receptor Binding Cytokine Activity Integrin Binding Protein Binding Growth Factor Activity Zinc Ion Binding Nickel Cation Binding Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding ErbB-3 Class Receptor Binding Chemorepellent Activity Receptor Ligand Activity
	Biological Process	Placenta Development Proteolysis Membrane Protein Ectodomain Proteolysis Positive Regulation Of Gene Expression Protein Processing Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Ventricular Trabecula Myocardium Morphogenesis Cell Communication Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Brain Development Peripheral Nervous System Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Cell Communication Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Regulation Of Signaling Cell Differentiation Positive Regulation Of Cell Growth Mammary Gland Development Positive Regulation Of Protein-containing Complex Assembly Activation Of Protein Kinase B Activity Intracellular Signal Transduction ERBB Signaling Pathway ERBB2 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB2-ERBB4 Signaling Pathway ERBB4-ERBB4 Signaling Pathway Wound Healing Positive Regulation Of Cell Adhesion Negative Regulation Of DNA-templated Transcription Negative Chemotaxis Negative Regulation Of Secretion Positive Regulation Of Developmental Process Positive Regulation Of Striated Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Myoblast Differentiation Endocardial Cell Differentiation Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Invadopodia formation Regulation of CDH11 function	Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Long-term potentiation Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
GWAS		Asthma ( 31959851 ) Blood protein levels ( 30072576 ) Body mass index ( 28552196 ) Chronic obstructive pulmonary disease ( 33909500 28166215 30804561 ) Eosinophil percentage of white cells ( 32888494 ) FEV1 ( 30804560 ) Inflammatory skin disease ( 25574825 ) Lung function (FEV1/FVC) ( 28166213 30804560 ) Medication use (adrenergics, inhalants) ( 31015401 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Peak expiratory flow ( 30804560 ) Pulmonary function ( 20010835 ) Pulmonary function (smoking interaction) ( 23284291 ) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577 ) Triglyceride levels ( 31647587 )	Bone mineral density (hip) ( 30172743 ) Cardiac Troponin-T levels ( 23247143 ) Cerebrospinal P-tau181p levels ( 28247064 ) Cerebrospinal T-tau levels ( 28247064 ) Chin dimples ( 27182965 ) Chronotype ( 30696823 ) Cognitive function ( 25644384 ) Coronary artery calcification ( 23870195 ) Dialysis-related mortality ( 21546767 ) Differentiated thyroid cancer ( 28703219 ) Diffusing capacity of carbon monoxide ( 30694715 ) Emphysema imaging phenotypes ( 26030696 ) Estimated glomerular filtration rate ( 31152163 30604766 ) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hip geometry ( 17903296 ) Hirschsprung disease ( 19196962 27702942 25310821 ) Hypothyroidism ( 27182965 ) Logical memory (delayed recall) in mild cognitive impairment ( 29274321 ) Logical memory (immediate recall) in mild cognitive impairment ( 29274321 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Major depressive disorder ( 29317602 ) Malaria ( 31844061 ) Metabolite levels (X-11787) ( 23934736 ) Morning person ( 30696823 ) Non-small cell lung cancer ( 31326317 ) Obstructive sleep apnea ( 25325441 ) Papillary thyroid cancer ( 28703219 ) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245 ) Pulse pressure ( 27841878 ) Refractive astigmatism ( 25367360 ) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834 ) Rheumatic heart disease ( 34106200 ) Serum thyroid-stimulating hormone levels ( 25436638 ) Thyroid cancer ( 22267200 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 ) Urate levels ( 31578528 ) Weight ( 28552196 )
Novel Interactors		None recorded	8 novel interactors: ADGRA2 CEBPD DKK4 EIF4EBP1 FGFR1 ISG20 KCNK4 LIPF
Interacting Genes		8 interacting genes: A2M ABI2 COPB1 DYRK1A FURIN NRG1 SH3GL2 TNFSF11	15 interacting genes: ADAM19 ASGR2 CD72 EGF EGFR ERBB2 ERBB3 ERBB4 IKZF4 JAGN1 LAPTM4B LIMK1 MS4A4A PLP1 TMEM54
Entrez ID		8728	3084
HPRD ID		04704	00802
Ensembl ID		ENSG00000135074	ENSG00000157168
Uniprot IDs		Q8TBU7 Q9H013	A0A024QY88 A0A494C0K4 A0A494C0L9 A0A494C0Q4 A0A494C114 A0A494C1B5 A0A494C1F5 A0A494C1F8 A5YAK6 A5YAK8 A6MW54 A6MW55 A6MW56 B0FWZ3 B0FYA7 B0FYA8 B0FYA9 B7Z1D7 B7Z1E3 E3SFM9 E5RHP6 Q02297 Q6PK61 Q7RTW3 Q7RTW5
PDB IDs		Not available	1HAE 1HAF 1HRE 1HRF 3U7U 7MN5 7MN6 7MN8 7SJL 8U4I 8U4L
GO Terms Enriched among Interactors		Signaling Receptor Binding Negative Regulation Of Complement Activation, Lectin Pathway Serine-type Endopeptidase Inhibitor Activity Peptidyl-tyrosine Phosphorylation System Development Actin Filament Histone H3T45 Kinase Activity Regulation Of Receptor Internalization Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Zymogen Inhibition Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Zonula Adherens Assembly Stem Cell Differentiation Protease Binding Interleukin-8 Binding Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Receptor Catabolic Process Negative Regulation Of Blood-brain Barrier Permeability Positive Regulation Of Osteoclast Development Positive Regulation Of Corticotropin-releasing Hormone Secretion Tumor Necrosis Factor Binding Interleukin-1 Binding Extracellular Space Golgi Membrane Negative Regulation Of Heterochromatin Formation Nervous System Development Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Ventricular Cardiac Muscle Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway ErbB-3 Class Receptor Binding Receptor Ligand Activity Positive Regulation Of Protein Autophosphorylation Regulation Of MAPK Cascade ERBB2-ERBB4 Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Endocardial Cell Differentiation Nickel Cation Binding ERBB4-ERBB4 Signaling Pathway	ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway ERBB2-EGFR Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Basal Plasma Membrane ERBB3:ERBB2 Complex Receptor Complex Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Signaling Receptor Activity Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Growth ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Positive Regulation Of Phosphate Metabolic Process ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Salivary Gland Morphogenesis Glial Cell Development Intracellular Signaling Cassette Positive Regulation Of Protein Modification Process Kinase Activity Regulation Of Protein Phosphorylation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Protein Tyrosine Kinase Activator Activity Regulation Of Phosphorylation Mammary Gland Alveolus Development Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction System Development Basolateral Plasma Membrane Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Myelination Axon Ensheathment