ADAM19 and NRG1

Number of citations of the paper that reports this interaction (PMID 11116142)
26

Data Source:
HPRD (in vitro)

		ADAM19	NRG1
Gene Name		ADAM metallopeptidase domain 19	neuregulin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Extracellular Region Extracellular Space Nucleus Cytoplasm Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Axon Neuromuscular Junction
	Molecular Function	Metalloendopeptidase Activity Zinc Ion Binding SH3 Domain Binding	Transcription Cofactor Activity Receptor Binding Cytokine Activity ErbB-2 Class Receptor Binding Protein Binding Growth Factor Activity Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding ErbB-3 Class Receptor Binding
	Biological Process	Membrane Protein Ectodomain Proteolysis Heart Development	MAPK Cascade Cell Morphogenesis Cardiac Conduction System Development Ventricular Trabecula Myocardium Morphogenesis Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Synapse Assembly Peripheral Nervous System Development Locomotory Behavior Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Embryo Development Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Cell Migration Glial Cell Fate Commitment Positive Regulation Of Cell Growth Mammary Gland Development Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway ERBB Signaling Pathway Wound Healing Negative Regulation Of Protein Catabolic Process Regulation Of Protein Homodimerization Activity Regulation Of Protein Heterodimerization Activity Cellular Protein Complex Disassembly Innate Immune Response Neurotransmitter Receptor Metabolic Process Positive Regulation Of Cell Adhesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Neuron Fate Commitment Negative Regulation Of Secretion Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Myoblast Differentiation Endocardial Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Pulmonary function ( 20010835) Pulmonary function (interaction) ( 23284291)	Cardiac Troponin-T levels ( 23247143) Dialysis-related mortality ( 21546767) Hip geometry ( 17903296) Hirschsprung's disease ( 19196962) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		7 interactors: A2M ABI2 COPB1 FURIN NRG1 SH3GL2 TNFSF11	7 interactors: ADAM19 EGF ERBB2 ERBB3 ERBB4 IKZF4 LIMK1
Entrez ID		8728	3084
HPRD ID		04704	00802
Ensembl ID		ENSG00000135074	ENSG00000157168
Uniprot IDs		E9PD32 Q8TBU7 Q9H013	A6MW55 A6MW56 B0FWZ3 B0FYA7 B0FYA8 B0FYA9 B7Z1D7 B7Z1E3 Q02297 Q6PK61 Q7RTW3 Q7RTW5
PDB IDs			1HAE 1HAF 1HRE 1HRF 3U7U
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Acute Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Locomotion Positive Regulation Of Corticotropin-releasing Hormone Secretion Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Extracellular Matrix Disassembly Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Catabolic Process Response To Growth Factor Regulation Of Protein Kinase B Signaling Nerve Growth Factor Production Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling TNFSF11-mediated Signaling Pathway Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Negative Regulation Of Complement Activation, Lectin Pathway Regulation Of Signaling Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Cell Proliferation Epidermal Growth Factor Receptor Signaling Pathway Cell Differentiation ERBB Signaling Pathway Signaling Mammary Gland Development Intracellular Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Osteoclast Development Nerve Growth Factor Processing Cell Communication Regulation Of Cellular Protein Metabolic Process Cell Migration Osteoclast Proliferation Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Establishment Of Localization In Cell Establishment Of Vesicle Localization Vesicle Localization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Enzyme Linked Receptor Protein Signaling Pathway Cell Motility MAPK Cascade Regulation Of Protein Metabolic Process Regulation Of Osteoclast Development	Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Innate Immune Response Cardiovascular System Development Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Kinase Activity Heart Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Immune Response Regulation Of Immune System Process Protein Phosphorylation Positive Regulation Of Transferase Activity Defense Response Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Phosphatidylinositol 3-kinase Signaling Regulation Of Peptidyl-tyrosine Phosphorylation Response To Wounding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Growth Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Phosphorylation Phosphorylation Signal Transduction By Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Mammary Gland Lobule Development Mammary Gland Alveolus Development Regulation Of Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Immune System Process Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Tyrosine Kinase Activity
Tagcloud ?		aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rhog rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2	appreciated cardiac cardiomyocyte cardiomyocytes cardiomyopathy chamber conscious contractility dilatation dilated dilation echocardiography ecs ejection erbb fractional hearts isoproterenol mechanistically neuregulin normalization normalized paracrine pecam proper shortening systolic tightly
Tagcloud (Difference) ?		aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rhog rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2	appreciated cardiac cardiomyocyte cardiomyocytes cardiomyopathy chamber conscious contractility dilatation dilated dilation echocardiography ecs ejection erbb fractional hearts isoproterenol mechanistically neuregulin normalization normalized paracrine pecam proper shortening systolic tightly
Tagcloud (Intersection) ?