ADAM19

Description		ADAM metallopeptidase domain 19
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Membrane Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Metal Ion Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
	Biological Process	Placenta Development Proteolysis Membrane Protein Ectodomain Proteolysis Positive Regulation Of Gene Expression Protein Processing Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Invadopodia formation Regulation of CDH11 function
Drugs
Diseases
GWAS		Asthma ( 31959851) Blood protein levels ( 30072576) Body mass index ( 28552196) Chronic obstructive pulmonary disease ( 33909500 28166215 30804561) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Inflammatory skin disease ( 25574825) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (adrenergics, inhalants) ( 31015401) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Peak expiratory flow ( 30804560) Pulmonary function ( 20010835) Pulmonary function (smoking interaction) ( 23284291) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577) Triglyceride levels ( 31647587)
Interacting Genes		8 interacting genes: A2M ABI2 COPB1 DYRK1A FURIN NRG1 SH3GL2 TNFSF11
Entrez ID		8728
HPRD ID		04704
Ensembl ID		ENSG00000135074
Uniprot IDs		Q8TBU7 Q9H013
PDB IDs
Enriched GO Terms of Interacting Partners?		Signaling Receptor Binding Negative Regulation Of Complement Activation, Lectin Pathway Serine-type Endopeptidase Inhibitor Activity Peptidyl-tyrosine Phosphorylation System Development Actin Filament Histone H3T45 Kinase Activity Regulation Of Receptor Internalization Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Zymogen Inhibition Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Zonula Adherens Assembly Stem Cell Differentiation Protease Binding Interleukin-8 Binding Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Receptor Catabolic Process Negative Regulation Of Blood-brain Barrier Permeability Positive Regulation Of Osteoclast Development Positive Regulation Of Corticotropin-releasing Hormone Secretion Tumor Necrosis Factor Binding Interleukin-1 Binding Extracellular Space Golgi Membrane Negative Regulation Of Heterochromatin Formation Nervous System Development Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Ventricular Cardiac Muscle Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway ErbB-3 Class Receptor Binding Receptor Ligand Activity Positive Regulation Of Protein Autophosphorylation Regulation Of MAPK Cascade ERBB2-ERBB4 Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Endocardial Cell Differentiation Nickel Cation Binding ERBB4-ERBB4 Signaling Pathway
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