USP10 and HDAC6

Number of citations of the paper that reports this interaction (PubMedID 32382008)
41

Data Source:
BioGRID (affinity chromatography technology, pull down, enzymatic study)

		USP10	HDAC6
Description		ubiquitin specific peptidase 10	histone deacetylase 6
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Cytosolic Ribosome Protein-containing Complex Intermediate Filament Cytoskeleton	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Multivesicular Body Centrosome Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Caveola Cilium Microtubule Cytoskeleton Inclusion Body Aggresome Axon Dendrite Cell Leading Edge Protein-containing Complex Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Plasma Membrane Bounded Cell Projection Axon Cytoplasm
	Molecular Function	P53 Binding RNA Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Transmembrane Transporter Binding Molecular Function Inhibitor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Actin Binding Histone Deacetylase Activity Protein Binding Beta-catenin Binding Microtubule Binding Zinc Ion Binding Transferase Activity Hydrolase Activity Deacetylase Activity Enzyme Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Protein Lysine Deacetylase Activity Peroxidase Inhibitor Activity ATPase Inhibitor Activity Histone Deacetylase Binding Tubulin Deacetylase Activity Alpha-tubulin Binding Ubiquitin Binding Metal Ion Binding Acetylspermidine Deacetylase Activity Tau Protein Binding Beta-tubulin Binding Misfolded Protein Binding Hsp90 Protein Binding Dynein Complex Binding Histone Deacetylase Activity, Hydrolytic Mechanism
	Biological Process	DNA Repair Chromatin Remodeling Proteolysis Protein Monoubiquitination Autophagy DNA Damage Response Regulation Of Autophagy Protein Deubiquitination Translesion Synthesis DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Stability Stress Granule Assembly Monoubiquitinated Protein Deubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Stress Granule Assembly Cellular Response To Interleukin-1 Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Protein Polyubiquitination Response To Amphetamine Chromatin Organization Protein Deacetylation Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Intracellular Protein Transport Autophagy Response To Stress Actin Filament Organization Negative Regulation Of Microtubule Depolymerization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Autophagy Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Mitochondrion Organization Negative Regulation Of Neuron Projection Development Macroautophagy Regulation Of Macroautophagy Axonal Transport Of Mitochondrion Neuron Differentiation Negative Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Protein Destabilization Lysosome Localization Positive Regulation Of Protein Oligomerization Regulation Of Microtubule-based Process Protein-containing Complex Disassembly Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Heat Response To Immobilization Stress Cellular Response To Topologically Incorrect Protein Aggrephagy Erythrocyte Enucleation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Fat Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Collateral Sprouting Negative Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Dendrite Morphogenesis Negative Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Response To Corticosterone Mitochondrion Localization Response To Misfolded Protein Positive Regulation Of Synaptic Transmission, Glutamatergic Cilium Assembly Regulation Of Microtubule-based Movement Regulation Of Androgen Receptor Signaling Pathway Dendritic Spine Morphogenesis Cilium Disassembly Type 2 Mitophagy Regulation Of Biological Quality Regulation Of Establishment Of Protein Localization Cellular Response To Hydrogen Peroxide Regulation Of Microtubule Cytoskeleton Organization Aggresome Assembly Polyubiquitinated Misfolded Protein Transport Protein Targeting To Vacuole Involved In Autophagy Cellular Response To Misfolded Protein Cellular Response To Parathyroid Hormone Stimulus Response To Dexamethasone Tubulin Deacetylation Macromolecule Deacylation Polyamine Deacetylation Spermidine Deacetylation Membraneless Organelle Assembly Positive Regulation Of Cellular Response To Oxidative Stress Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Type 2 Mitophagy Negative Regulation Of Aggrephagy
Pathways		Termination of translesion DNA synthesis Ub-specific processing proteases	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HSF1 activation Notch-HLH transcription pathway Cargo trafficking to the periciliary membrane Transcriptional regulation by RUNX2 RUNX2 regulates osteoblast differentiation Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs			Valproic acid Decitabine Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide Bufexamac
Diseases
GWAS		Appendicular lean mass ( 33097823) Copper levels ( 26025379) Height ( 18391951) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Plasma factor VII activating protease levels ( 30070759) Response to mTOR inhibitor (everolimus) ( 24009623) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		32 interacting genes: AKT1 ANLN AR AXIN1 CCND3 CFTR CTNNB1 DAAM1 FSCN1 FZR1 G3BP1 G3BP2 H2AC20 HDAC6 HNRNPLL KLF4 LINC00460 MAP1LC3B MSH2 NOTCH1 PABPC1 PCGF5 RAD51 RUNX1 SCNN1A SCNN1G SMAD4 SNX3 SOX21-AS1 TRNAU1AP UBC ZBTB7A	83 interacting genes: ADRB2 APOBEC3G ARHGDIA ATF3 BBS10 BCL3 BCOR BRMS1 CDKN1A CEP70 CRBN CSNK2A2 CYLD DSCR9 DYNLL2 EP300 ERBB2 ERBB3 ERBB4 FBP1 FBXO11 FNTA FNTB GRK2 H2AX H4C16 HDAC11 HES1 HTATIP2 HTATSF1 ISG15 JDP2 KPNA1 LCOR LINC00624 LPXN MAPK1 MAPK3 MAPT MLH1 MOB1A MSH2 NACAD NASP NEDD8 NR0B2 NR3C1 PLAA POLA2 POLDIP2 POLR1B PPP1CC PRDX4 PRKCZ PRKN PROM1 PTOV1 PXN RELB RNF168 RNF31 RUNX2 SEPTIN7 SIRT2 SYK TEKT4 TPPP TRIM50 TUBA1B TUBA4A TUBB TUBB2B UBB UBC UBE2D1 UBE2D3 UBE2E1 UBE2H USP10 VCP VKORC1 ZBTB16 ZNF205
Entrez ID		9100	10013
HPRD ID		07029	02228
Ensembl ID		ENSG00000103194	ENSG00000094631
Uniprot IDs		A0A7G6J4N4 Q14694	B4DZH6 Q9BRX7 Q9UBN7
PDB IDs		7XHF 8TH6	3C5K 3GV4 3PHD 5B8D 5EDU 5KH3 5KH7 5KH9 5WBN 5WPB 6CE6 6CE8 6CEA 6CEC 6CED 6CEE 6CEF 7ZYU 8G43 8G44 8G45
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Binding Positive Regulation Of Cellular Component Organization Enzyme Binding Response To Alcohol Epithelial Cell Differentiation Involved In Prostate Gland Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process SMAD Binding Cellular Response To Oxygen-containing Compound Cellular Response To Hormone Stimulus Response To Ketone Negative Regulation Of Macromolecule Metabolic Process I-SMAD Binding Negative Regulation Of RNA Metabolic Process In Utero Embryonic Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Proliferation Involved In Heart Morphogenesis Chordate Embryonic Development Positive Regulation Of Gene Expression Epithelial Cell Differentiation Regulation Of Extracellular Matrix Organization Negative Regulation Of Metabolic Process Response To Lipid Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Axis Specification Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Cytosol Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Extracellular Matrix Organization Cell Cortex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Negative Regulation Of Biosynthetic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Organelle Assembly Positive Regulation Of Epithelial Cell Proliferation Regulation Of Mitotic Cell Cycle Endocardial Cell Differentiation Positive Regulation Of Cellular Component Biogenesis Beta-catenin Binding Response To Mineralocorticoid Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Protein-containing Complex	Nucleus Protein Modification Process Cytosol Protein Ubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Protein-containing Complex Protein Modification By Small Protein Conjugation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Response To Stress Microtubule Cytoskeleton ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Protein Modification Process ERBB2 Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Deacetylation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Nucleoplasm Protein Tag Activity Regulation Of Signal Transduction Negative Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Regulation Of Gene Expression Regulation Of Protein-containing Complex Assembly Glial Cell Differentiation Positive Regulation Of Developmental Process DNA Damage Response Cell Differentiation Cellular Response To Stress Developmental Process Regulation Of DNA-templated Transcription Regulation Of Signaling Regulation Of Cell Communication
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