USP10 and PABPC1

Number of citations of the paper that reports this interaction (PubMedID 37757903)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		USP10	PABPC1
Description		ubiquitin specific peptidase 10	poly(A) binding protein cytoplasmic 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Cytosolic Ribosome Protein-containing Complex Intermediate Filament Cytoskeleton	Nucleus Spliceosomal Complex Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Lamellipodium Cell Leading Edge Cytoplasmic Ribonucleoprotein Granule Cell Projection Extracellular Exosome Catalytic Step 2 Spliceosome MCRD-mediated MRNA Stability Complex Ribonucleoprotein Complex
	Molecular Function	P53 Binding RNA Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Transmembrane Transporter Binding Molecular Function Inhibitor Activity	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity
	Biological Process	DNA Repair Chromatin Remodeling Proteolysis Protein Monoubiquitination Autophagy DNA Damage Response Regulation Of Autophagy Protein Deubiquitination Translesion Synthesis DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Stability Stress Granule Assembly Monoubiquitinated Protein Deubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Stress Granule Assembly Cellular Response To Interleukin-1 Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Viral Genome Replication MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Cytoplasmic Translation
Pathways		Termination of translesion DNA synthesis Ub-specific processing proteases	L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Copper levels ( 26025379) Height ( 18391951) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Plasma factor VII activating protease levels ( 30070759) Response to mTOR inhibitor (everolimus) ( 24009623) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Body mass index ( 26426971) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		32 interacting genes: AKT1 ANLN AR AXIN1 CCND3 CFTR CTNNB1 DAAM1 FSCN1 FZR1 G3BP1 G3BP2 H2AC20 HDAC6 HNRNPLL KLF4 LINC00460 MAP1LC3B MSH2 NOTCH1 PABPC1 PCGF5 RAD51 RUNX1 SCNN1A SCNN1G SMAD4 SNX3 SOX21-AS1 TRNAU1AP UBC ZBTB7A	55 interacting genes: ANAPC5 APBB1 ATXN2 CARM1 CEBPA CHAF1A CNOT6 CNOT7 CSDE1 DUX4 EIF4B EIF4G1 EIF4G3 ERBB2 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH LARP4B LINC01554 MAPKAPK2 MKRN1 NDRG1 OGT PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCSK7 PIN1 PRMT6 PXN RACK1 RBM4 SNCA SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 TOB2 U2AF1 UNK USP10 USP7 WBP4 WEE2-AS1 YWHAG
Entrez ID		9100	26986
HPRD ID		07029	05247
Ensembl ID		ENSG00000103194	ENSG00000070756
Uniprot IDs		A0A7G6J4N4 Q14694	P11940
PDB IDs		7XHF 8TH6	1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26 5DX1 5DX8 5DXA 5LGP 5LGQ 5LGR 5LGS 7BN3 8SMO
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Binding Positive Regulation Of Cellular Component Organization Enzyme Binding Response To Alcohol Epithelial Cell Differentiation Involved In Prostate Gland Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process SMAD Binding Cellular Response To Oxygen-containing Compound Cellular Response To Hormone Stimulus Response To Ketone Negative Regulation Of Macromolecule Metabolic Process I-SMAD Binding Negative Regulation Of RNA Metabolic Process In Utero Embryonic Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Proliferation Involved In Heart Morphogenesis Chordate Embryonic Development Positive Regulation Of Gene Expression Epithelial Cell Differentiation Regulation Of Extracellular Matrix Organization Negative Regulation Of Metabolic Process Response To Lipid Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Axis Specification Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Cytosol Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Extracellular Matrix Organization Cell Cortex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Negative Regulation Of Biosynthetic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Organelle Assembly Positive Regulation Of Epithelial Cell Proliferation Regulation Of Mitotic Cell Cycle Endocardial Cell Differentiation Positive Regulation Of Cellular Component Biogenesis Beta-catenin Binding Response To Mineralocorticoid Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Protein-containing Complex	Post-transcriptional Regulation Of Gene Expression Regulation Of Translation RNA Binding Regulation Of Protein Metabolic Process Regulation Of Translational Initiation Positive Regulation Of Translation Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Catabolic Process Regulation Of MRNA Stability Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Negative Regulation Of Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MCRD-mediated MRNA Stability Complex Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Translation MRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Cytosol Nucleic Acid Binding Nucleic Acid Metabolic Process Negative Regulation Of Protein Metabolic Process MRNA Metabolic Process Regulation Of Biological Quality Cytoplasmic Stress Granule CRD-mediated MRNA Stabilization RNA Metabolic Process Poly(A)-specific Ribonuclease Activity Positive Regulation Of Metabolic Process Negative Regulation Of MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cytoplasmic Translation Positive Regulation Of Biosynthetic Process MRNA Catabolic Process Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Cytoplasmic Translation RNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Translational Initiation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly
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