USP10 and SCNN1A

Number of citations of the paper that reports this interaction (PMID 18632802)
10

Data Source:
HPRD (in vivo)

		USP10	SCNN1A
Gene Name		ubiquitin specific peptidase 10	sodium channel, non voltage gated 1 alpha subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome	Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Cortical Actin Cytoskeleton Motile Cilium Sodium Channel Complex Ciliary Membrane Extracellular Vesicular Exosome
	Molecular Function	P53 Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Ion Channel Binding Poly(A) RNA Binding	Actin Binding Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding
	Biological Process	DNA Repair Autophagy Regulation Of Autophagy Protein Deubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process	Sodium Ion Transport Excretion Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal Water Homeostasis Response To Stimulus Sensory Perception Of Taste Sodium Ion Homeostasis Transmembrane Transport
Pathways			Ion channel transport Stimuli-sensing channels
Drugs			Triamterene Amiloride
Diseases
GWAS		Height ( 18391951)	Obesity (early onset extreme) ( 23563609)
Protein-Protein Interactions		9 interactors: AR G3BP1 G3BP2 IKBKG SCNN1A SCNN1G SNX3 TP53 UBC	16 interactors: CSNK2A1 EPN1 HECW1 ITCH NEDD4 NEDD4L SCNN1B SCNN1G SERP1 SNX3 STX1A TSG101 UBE2I USP10 WWP1 WWP2
Entrez ID		9100	6337
HPRD ID		07029	02575
Ensembl ID		ENSG00000103194	ENSG00000111319
Uniprot IDs		Q14694	F5GXE6 P37088
PDB IDs			2M3O
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signaling Transport Sodium Ion Homeostasis Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Ras Protein Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Stimulus Regulation Of Establishment Of Protein Localization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Localization Excretion Multicellular Organismal Water Homeostasis Regulation Of Wnt Signaling Pathway Toll-like Receptor 5 Signaling Pathway Positive Regulation Of Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Toll-like Receptor 10 Signaling Pathway Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signal Transduction Involved In DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Signal Transduction Involved In Cell Cycle Checkpoint Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Apoptotic Process Toll-like Receptor 9 Signaling Pathway Negative Regulation Of Programmed Cell Death Water Homeostasis TRIF-dependent Toll-like Receptor Signaling Pathway Sensory Perception Of Taste MyD88-independent Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Death Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Localization DNA Damage Response, Signal Transduction By P53 Class Mediator	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Viral Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Catabolic Process Viral Life Cycle Proteolysis Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Sodium Ion Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Catabolic Process Interaction With Host Cellular Protein Modification Process Regulation Of Potassium Ion Transmembrane Transporter Activity Protein K63-linked Ubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Potassium Ion Transmembrane Transport Viral Entry Into Host Cell Entry Into Host Cell Excretion Protein Polyubiquitination Regulation Of Signaling Regulation Of Potassium Ion Transport Water Homeostasis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Sodium Ion Transport Negative Regulation Of Cellular Metabolic Process Regulation Of Membrane Potential Regulation Of Cellular Localization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transport Regulation Of Vesicle-mediated Transport Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Transport Regulation Of Transmembrane Transporter Activity Regulation Of Protein Localization Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction
Tagcloud ?		bioinformatic class collectively crucial experiments function gain implicating inhibit initiation luciferase micrornas mir molecules noncoding oncogenic pancreatic play prediction pro progression promote roles stabilizing suggested suppressed targeting tumorigenesis ups10	aldosterone atp1a1 atpasealpha1 betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption stepwise synergy transcriptomic
Tagcloud (Difference) ?		bioinformatic class collectively crucial experiments function gain implicating inhibit initiation luciferase micrornas mir molecules noncoding oncogenic pancreatic play prediction pro progression promote roles stabilizing suggested suppressed targeting tumorigenesis ups10	aldosterone atp1a1 atpasealpha1 betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption stepwise synergy transcriptomic
Tagcloud (Intersection) ?