USP10 and FZR1

Number of citations of the paper that reports this interaction (PubMedID 36526897)
63

Data Source:
BioGRID (pull down)

		USP10	FZR1
Description		ubiquitin specific peptidase 10	fizzy and cell division cycle 20 related 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Cytosolic Ribosome Protein-containing Complex Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	P53 Binding RNA Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Transmembrane Transporter Binding Molecular Function Inhibitor Activity	Protein Binding Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity
	Biological Process	DNA Repair Chromatin Remodeling Proteolysis Protein Monoubiquitination Autophagy DNA Damage Response Regulation Of Autophagy Protein Deubiquitination Translesion Synthesis DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Stability Stress Granule Assembly Monoubiquitinated Protein Deubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Stress Granule Assembly Cellular Response To Interleukin-1 Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	DNA Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Meiotic Nuclear Division Thymidine Biosynthetic Process Cell Division Regulation Of Meiotic Cell Cycle Proteolysis Involved In Protein Catabolic Process Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Cellular Senescence
Pathways		Termination of translesion DNA synthesis Ub-specific processing proteases	Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Copper levels ( 26025379) Height ( 18391951) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Plasma factor VII activating protease levels ( 30070759) Response to mTOR inhibitor (everolimus) ( 24009623) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Red cell distribution width ( 32888494)
Interacting Genes		32 interacting genes: AKT1 ANLN AR AXIN1 CCND3 CFTR CTNNB1 DAAM1 FSCN1 FZR1 G3BP1 G3BP2 H2AC20 HDAC6 HNRNPLL KLF4 LINC00460 MAP1LC3B MSH2 NOTCH1 PABPC1 PCGF5 RAD51 RUNX1 SCNN1A SCNN1G SMAD4 SNX3 SOX21-AS1 TRNAU1AP UBC ZBTB7A	95 interacting genes: AKT1S1 ANAPC1 ANAPC11 ANAPC2 ANAPC7 ANLN ARNT BECN1 BEX1 BLID BTRC C7orf25 CCL5 CCNA1 CCNB1 CCND2 CCNE1 CCNF CDC14A CDC27 CDC6 CDK2 CDK4 CDK5 CDK6 CDKN2B CDR2 CDT1 CLSPN CYP17A1 DCPS DKK3 DNAJA1 DNM1L DTYMK E2F3 EPHA2 EPSTI1 ERBB2 FBXO5 FGFR4 GLIS2 GMNN HECW2 HIF1A ID2 KAT2A KIF18B LATS2 MAD2L2 MAK MAP2K3 MAP2K5 MAP3K5 MAPK8 MET MOAP1 MTA3 MYC NAT2 NEDD9 NEK2 NF2 OTUD7B PAX3 PDGFRA PSMC3IP PTP4A3 PTTG1 RASSF1 RB1 RBBP8 SASS6 SENP2 SIRT1 SIRT2 SKIL SKP2 SMURF1 SOX2 SOX4 SRC STK11 TBK1 TEAD2 TERT THRSP TK1 TTF2 UBC UBE2D1 UBE2D3 UBE2K UHRF1 USP10
Entrez ID		9100	51343
HPRD ID		07029	04687
Ensembl ID		ENSG00000103194	ENSG00000105325
Uniprot IDs		A0A7G6J4N4 Q14694	Q9UM11
PDB IDs		7XHF 8TH6	4UI9 5L9T 5L9U 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Binding Positive Regulation Of Cellular Component Organization Enzyme Binding Response To Alcohol Epithelial Cell Differentiation Involved In Prostate Gland Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process SMAD Binding Cellular Response To Oxygen-containing Compound Cellular Response To Hormone Stimulus Response To Ketone Negative Regulation Of Macromolecule Metabolic Process I-SMAD Binding Negative Regulation Of RNA Metabolic Process In Utero Embryonic Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Proliferation Involved In Heart Morphogenesis Chordate Embryonic Development Positive Regulation Of Gene Expression Epithelial Cell Differentiation Regulation Of Extracellular Matrix Organization Negative Regulation Of Metabolic Process Response To Lipid Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Axis Specification Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Cytosol Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Extracellular Matrix Organization Cell Cortex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Negative Regulation Of Biosynthetic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Organelle Assembly Positive Regulation Of Epithelial Cell Proliferation Regulation Of Mitotic Cell Cycle Endocardial Cell Differentiation Positive Regulation Of Cellular Component Biogenesis Beta-catenin Binding Response To Mineralocorticoid Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Protein-containing Complex	Regulation Of Cell Cycle Regulation Of Cell Cycle Process Cell Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleoplasm G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Nucleus Regulation Of Primary Metabolic Process Cytoplasm Regulation Of Chromosome Segregation Cytosol Regulation Of Chromosome Organization Regulation Of Sister Chromatid Segregation Regulation Of Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Negative Regulation Of Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Kinase Activity Positive Regulation Of Cell Cycle Phase Transition Spindle Protein Kinase Activity Regulation Of Organelle Organization Negative Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Process Post-translational Protein Modification Negative Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Cell Population Proliferation Cellular Response To Stress Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Transferase Activity Positive Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process
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