USP10 and PCGF5

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		USP10	PCGF5
Description		ubiquitin specific peptidase 10	polycomb group ring finger 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Cytosolic Ribosome Protein-containing Complex Intermediate Filament Cytoskeleton	X Chromosome Nucleus Nucleoplasm Golgi Apparatus Centrosome PcG Protein Complex PRC1 Complex
	Molecular Function	P53 Binding RNA Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Transmembrane Transporter Binding Molecular Function Inhibitor Activity	Protein Binding Zinc Ion Binding Metal Ion Binding Histone H2AK119 Ubiquitin Ligase Activity
	Biological Process	DNA Repair Chromatin Remodeling Proteolysis Protein Monoubiquitination Autophagy DNA Damage Response Regulation Of Autophagy Protein Deubiquitination Translesion Synthesis DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Stability Stress Granule Assembly Monoubiquitinated Protein Deubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Stress Granule Assembly Cellular Response To Interleukin-1 Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Random Inactivation Of X Chromosome
Pathways		Termination of translesion DNA synthesis Ub-specific processing proteases	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Copper levels ( 26025379) Height ( 18391951) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Plasma factor VII activating protease levels ( 30070759) Response to mTOR inhibitor (everolimus) ( 24009623) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Chronotype ( 30696823) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		32 interacting genes: AKT1 ANLN AR AXIN1 CCND3 CFTR CTNNB1 DAAM1 FSCN1 FZR1 G3BP1 G3BP2 H2AC20 HDAC6 HNRNPLL KLF4 LINC00460 MAP1LC3B MSH2 NOTCH1 PABPC1 PCGF5 RAD51 RUNX1 SCNN1A SCNN1G SMAD4 SNX3 SOX21-AS1 TRNAU1AP UBC ZBTB7A	9 interacting genes: CBX7 CBX8 DHX57 PRMT6 QKI TRAF2 TRIM8 UBE2D3 USP10
Entrez ID		9100	84333
HPRD ID		07029	17825
Ensembl ID		ENSG00000103194	ENSG00000180628
Uniprot IDs		A0A7G6J4N4 Q14694	Q86SE9
PDB IDs		7XHF 8TH6	4S3O
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Binding Positive Regulation Of Cellular Component Organization Enzyme Binding Response To Alcohol Epithelial Cell Differentiation Involved In Prostate Gland Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process SMAD Binding Cellular Response To Oxygen-containing Compound Cellular Response To Hormone Stimulus Response To Ketone Negative Regulation Of Macromolecule Metabolic Process I-SMAD Binding Negative Regulation Of RNA Metabolic Process In Utero Embryonic Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Proliferation Involved In Heart Morphogenesis Chordate Embryonic Development Positive Regulation Of Gene Expression Epithelial Cell Differentiation Regulation Of Extracellular Matrix Organization Negative Regulation Of Metabolic Process Response To Lipid Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Axis Specification Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Cytosol Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Extracellular Matrix Organization Cell Cortex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Negative Regulation Of Biosynthetic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Organelle Assembly Positive Regulation Of Epithelial Cell Proliferation Regulation Of Mitotic Cell Cycle Endocardial Cell Differentiation Positive Regulation Of Cellular Component Biogenesis Beta-catenin Binding Response To Mineralocorticoid Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Protein-containing Complex	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process PRC1 Complex Regulation Of Metabolic Process PcG Protein Complex Stress Granule Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Ubiquitination Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Post-translational Protein Modification Protein Polyubiquitination TORC2 Complex Disassembly Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process MRNA Stabilization Cellular Response To Stress Negative Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Protein Autoubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Protein Monoubiquitination Chromatin Organization Internal N(7)-methylguanine-containing RNA Reader Activity Histone H2AR3 Methyltransferase Activity Ubiquitin Protein Ligase Activity Regulation Of Macromolecule Metabolic Process Protein K63-linked Ubiquitination Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Stress Granule Assembly Myofibroblast Contraction Negative Regulation Of MiRNA Catabolic Process Histone H3R2 Methyltransferase Activity Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Histone Arginine N-methyltransferase Activity Response To Stress Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex DNA Repair
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