SERPINH1 and BRCA2

Number of citations of the paper that reports this interaction (PubMedID 19578754)
0

Data Source:
BioGRID (pull down)

		SERPINH1	BRCA2
Description		serpin family H member 1	BRCA2 DNA repair associated
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Extracellular Matrix Membrane Raft	Nuclear Ubiquitin Ligase Complex Chromosome, Telomeric Region Lateral Element Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Secretory Granule Protein-containing Complex BRCA2-MAGE-D1 Complex DNA Repair Complex
	Molecular Function	RNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Collagen Binding Unfolded Protein Binding	Protease Binding DNA Binding Single-stranded DNA Binding Histone Acetyltransferase Activity Protein Binding Histone H3 Acetyltransferase Activity Histone H4 Acetyltransferase Activity Identical Protein Binding Gamma-tubulin Binding
	Biological Process	Chondrocyte Development Involved In Endochondral Bone Morphogenesis Response To Unfolded Protein Collagen Fibril Organization Collagen Biosynthetic Process Protein Maturation	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Oocyte Maturation Inner Cell Mass Cell Proliferation DNA Repair Nucleotide-excision Repair Double-strand Break Repair DNA Recombination Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Male Meiosis I Spermatogenesis Brain Development Cell Population Proliferation Female Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To X-ray Response To UV-C Response To Gamma Radiation Hemopoiesis DNA Damage Response, Signal Transduction By P53 Class Mediator Replication Fork Processing Regulation Of Cytokinesis Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Chordate Embryonic Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Chromosome Organization Centrosome Duplication Establishment Of Protein Localization To Telomere Hematopoietic Stem Cell Proliferation Cellular Response To Ionizing Radiation Stem Cell Proliferation Cellular Senescence Mitotic Recombination-dependent Replication Fork Processing Regulation Of DNA Damage Checkpoint
Pathways		Collagen biosynthesis and modifying enzymes	HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 translocation to the nucleus Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2 Impaired BRCA2 binding to SEM1 (DSS1)
Drugs
Diseases			Ovarian cancer Fanconi anemia Breast cancer Pancreatic cancer
GWAS		A body shape index ( 34021172) Coronary artery disease ( 33020668 29212778) Height ( 22021425 33713608 31562340 28552196 28270201 25429064 25282103 20881960) Hip circumference adjusted for BMI ( 25673412 34021172) Myocardial infarction ( 33532862) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172)	Apolipoprotein B levels ( 32203549) Basal cell carcinoma ( 31174203) Breast cancer ( 23535733 23535729 29059683) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol ( 24097068) LDL cholesterol levels ( 32203549 28334899) Lung cancer ( 28604730 24880342) Lung cancer in ever smokers ( 28604730) Small cell lung carcinoma ( 28604730) Squamous cell carcinoma ( 31174203) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		20 interacting genes: BAG6 BRCA2 C1QL3 CD9 CDK9 CEP70 COL26A1 ESR2 FEZ1 H1-5 KAT2B KLF13 LINC01554 NSG2 OGT PPARG SLC2A4 SLC35F6 UBQLN4 UBTF	47 interacting genes: ATR BCCIP BRCA1 BUB1B CCNA1 CCNA2 CCND1 CCNE1 CDK1 CDK2 CFAP52 CHEK1 CHEK2 DMC1 DYNC1LI1 DYNC1LI2 EMSY ERCC5 FANCD2 FANCE FANCG FANCI FLNA H2AX HMG20B HNRNPC KAT2B LIMD1 MAGED1 PALB2 PDS5B PLEC PLK1 RAD51 RNASEH2A RPA1 SEM1 SERPINH1 SMAD3 STAT5A TP53 TP53BP1 UQCC1 USP11 USP21 WTIP XPO1
Entrez ID		871	675
HPRD ID		02968	02554
Ensembl ID		ENSG00000149257	ENSG00000139618
Uniprot IDs		A8K259 P50454	A0A7P0T9D7 A0A8V8TPZ2 P51587
PDB IDs			1N0W 3EU7 6GY2 6HQU 7BDX 7LDG 8BR9 8C3J 8C3N 8PBC 8PBD 8QQE 8R2G 8UVW
Enriched GO Terms of Interacting Partners?		Gamma-tubulin Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Carbon Catabolite Regulation Of Transcription Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Response To Insulin Regulation Of Transcription By Glucose Internal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Negative Regulation Of Cellular Component Organization Cellular Response To Insulin Stimulus Regulation Of Cellular Response To Stress Chromatin Organization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Histone Acetyltransferase Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Peptide Hormone Histone Acetyltransferase Activity Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Lipid Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Metabolic Process Response To Nutrient Protein Acetylation Replication Fork Processing BRCA2-MAGE-D1 Complex Positive Regulation Of RNA Metabolic Process Cellular Response To Lipoprotein Particle Stimulus Host-mediated Activation Of Viral Process Pyruvate Carboxylase Activity Positive Regulation Of Fatty Acid Metabolic Process Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Cellular Response To Nutrient Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Negative Regulation Of Macroautophagy Collagen Type XXVI Trimer Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	DNA Repair DNA Metabolic Process DNA Damage Response DNA Damage Checkpoint Signaling Cellular Response To Stress Double-strand Break Repair Nucleoplasm Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition Response To Stress Mitotic DNA Damage Checkpoint Signaling Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle Cell Cycle Phase Transition Nucleus Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Chromosome, Telomeric Region Regulation Of Mitotic Cell Cycle Protein Localization To Site Of Double-strand Break G2/M Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Chromosome Organization Recombinational Repair Response To Ionizing Radiation Cell Cycle G2/M Phase Transition Chromosome DNA Repair Complex Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Organelle Organization Regulation Of Cell Cycle G2/M Phase Transition Interstrand Cross-link Repair Regulation Of Mitotic Cell Cycle Phase Transition Condensed Nuclear Chromosome Centrosome DNA Recombination Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Localization To Chromosome Regulation Of Chromosome Organization Cyclin A2-CDK2 Complex Response To Radiation Damaged DNA Binding
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