SERPINH1 and UBTF

Number of citations of the paper that reports this interaction (PMID 11106745)
42

Data Source:
HPRD (in vivo, in vitro)

		SERPINH1	UBTF
Gene Name		serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	upstream binding transcription factor, RNA polymerase I
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Extracellular Vesicular Exosome	Nucleoplasm Nucleolus
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Collagen Binding Poly(A) RNA Binding Unfolded Protein Binding	DNA Binding Chromatin Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Chondrocyte Development Involved In Endochondral Bone Morphogenesis Response To Unfolded Protein Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Collagen Fibril Organization Collagen Biosynthetic Process Protein Maturation	Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase I Promoter
Pathways		Collagen formation Collagen biosynthesis and modifying enzymes	NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression RNA Polymerase I Promoter Opening
Drugs
Diseases
GWAS		Height ( 20881960 22021425)
Protein-Protein Interactions		17 interactors: BAG6 BRCA2 C1QL3 CD9 CDK9 CEP70 COL26A1 ESR2 FEZ1 HIST1H1B HMP19 KLF13 PPARG SLC2A4 SLC35F6 UBQLN4 UBTF	31 interactors: CCNA2 CCND1 CCNE1 CD3EAP CDK2 CDK4 CENPC CHGB CREBBP CSNK2A1 IRS1 IRS2 LEF1 MAD1L1 MAPK1 MAPK3 MDM2 POLR1E RB1 RBL2 RUNX2 SERPINH1 SMURF1 TAF1 TAF1A TAF1B TAF1C TAF1D TBP TCOF1 ZMYM2
Entrez ID		871	7343
HPRD ID		02968	02814
Ensembl ID		ENSG00000149257	ENSG00000108312
Uniprot IDs		A8K259 P50454	P17480
PDB IDs			1K99 1L8Y 1L8Z 2HDZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Replication DNA-templated Transcription, Initiation Regulation Of Cell Proliferation Negative Regulation Of DNA Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of DNA Replication Cell Maturation Regulation Of Cellular Component Organization Transcription Initiation From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Cellular Metabolic Process Brown Fat Cell Differentiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Metformin Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Pancreatic Stellate Cell Proliferation Replication Fork Arrest Response To Diuretic Amylopectin Biosynthetic Process Single Organism Reproductive Process Regulation Of Cellular Process Chromatin Organization Regulation Of Cholesterol Transporter Activity Cellular Response To Vitamin E DNA-templated Transcription, Elongation Reproductive Process Apoptotic Signaling Pathway Regulation Of Cell Growth Brain Development Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Protein Stabilization Macromolecule Biosynthetic Process Head Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Multicellular Organism Reproduction Steroid Hormone Mediated Signaling Pathway Meiosis I Membrane Organization DNA-dependent DNA Replication Cellular Response To Oxygen Levels Transcription From RNA Polymerase II Promoter Female Gonad Development Regulation Of Gene Expression Signal Transduction By P53 Class Mediator Development Of Primary Female Sexual Characteristics Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation	Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter DNA-templated Transcription, Initiation DNA-templated Transcription, Elongation Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Chromatin Silencing At RDNA Cellular Macromolecule Biosynthetic Process Gene Expression Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Regulation Of Cell Cycle Phase Transition RNA Metabolic Process Regulation Of Transcription, DNA-templated Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Chromatin Silencing Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Checkpoint Regulation Of RNA Metabolic Process Cell Division Positive Regulation Of Cellular Biosynthetic Process Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Cell Cycle Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Gene Expression, Epigenetic Negative Regulation Of Mitotic Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Checkpoint Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway RRNA Transcription
Tagcloud ?		act biochemical bones caused chaperones consequences deficiency destabilization disorder dominant encode fkbp10 forms genes genetic growing include interact little maturation mislocalization moderately mutant mutation posttranslational predominantly produce reveal secondarily severe
Tagcloud (Difference) ?		act biochemical bones caused chaperones consequences deficiency destabilization disorder dominant encode fkbp10 forms genes genetic growing include interact little maturation mislocalization moderately mutant mutation posttranslational predominantly produce reveal secondarily severe
Tagcloud (Intersection) ?