MTIF3 and LAPTM4B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MTIF3	LAPTM4B
Description		mitochondrial translational initiation factor 3	lysosomal protein transmembrane 4 beta
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Lysosome Lysosomal Membrane Endosome Early Endosome Plasma Membrane Endosome Membrane Endomembrane System Membrane Late Endosome Membrane Multivesicular Body Membrane Cell Projection Multivesicular Body, Internal Vesicle
	Molecular Function	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ribosome Binding Ribosomal Small Subunit Binding	Protein Binding Kinase Binding Ubiquitin Protein Ligase Binding Ceramide Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Translation Translational Initiation Ribosome Disassembly Mitochondrial Translational Initiation	Endosome Organization Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Lysosomal Membrane Permeability Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Lysosome Organization
Pathways		Mitochondrial translation initiation
Drugs
Diseases
GWAS		Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) BMI x environmental factors (excluding physical activity) interaction ( 33654129) BMI x environmental factors (including physical activity) interaction ( 33654129) Body mass index ( 20935630 25673413 28892062) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Estimated glomerular filtration rate change in renal transplantation (recipient effect) ( 30920136) Night sleep phenotypes ( 27126917) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603)	Metabolite levels ( 23823483) QT interval ( 24952745)
Interacting Genes		88 interacting genes: ADGRE2 APOD BCL2L1 BMP10 BPIFA1 BRICD5 CABP7 CD47 CDIPT CDS2 CGRRF1 CLDND2 CLEC7A CMTM5 COL4A5 COQ8A CTXN3 CXCL9 CYBC1 CYP4F2 EPGN FBXO7 FETUB FXYD3 FXYD6-FXYD2 HSFX1 HSFX2 HTATIP2 INSIG2 ITGB2 JAGN1 LAPTM4B LAT LDLR LHFPL5 MAPK1 MGST3 MRFAP1 MS4A1 NAT8 NDRG4 ORMDL1 ORMDL2 ORMDL3 PAXIP1 PEA15 PLN PLP1 PRH1 RPRM SCD SELENOK SERP1 SERP2 SERTM1 SIAH1 SNX2 SPANXN2 STARD4 STATH STRIT1 STX3 STX6 THBD THSD7B TMED8 TMEM109 TMEM11 TMEM128 TMEM147 TMEM176A TMEM218 TMEM239 TMEM242 TMEM243 TMEM254 TMEM42 TMEM97 TRARG1 TSPAN33 TUFM UNC50 VAMP4 VEZT VKORC1L1 YIPF6 ZDHHC15 ZNF202	21 interacting genes: BDKRB1 CGRRF1 CTXN3 CYB561A3 EMP1 GJA8 GPX8 IFNAR1 IGFBP5 ISLR2 MTIF3 NAALADL2 NRG1 ODF4 PIP5K1C SCARB2 SLC22A1 SLC22A2 SLC29A2 TMEM86B TRARG1
Entrez ID		219402	55353
HPRD ID		17609	13960
Ensembl ID		ENSG00000122033	ENSG00000104341
Uniprot IDs		Q9H2K0	Q86VI4
PDB IDs		6NEQ 6NF8 6RW4 6RW5 7P2E 8QRM
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Serine Palmitoyltransferase Complex Regulation Of Transport Regulation Of Lipid Biosynthetic Process Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Synaptic Vesicle To Endosome Fusion Regulation Of Cellular Localization Granulocyte Migration Regulation Of Cholesterol Metabolic Process Regulation Of Membrane Lipid Metabolic Process Respiratory Burst After Phagocytosis Negative Regulation Of Lipid Metabolic Process Regulation Of Lipid Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Neutrophil Migration Cholesterol Import Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Cholesterol Metabolic Process Myeloid Leukocyte Migration	Pyrimidine-containing Compound Transmembrane Transport Neurotransmitter Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Membrane Neurotransmitter Uptake Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Purine-containing Compound Transmembrane Transport Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Xenobiotic Transport Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Serotonin Uptake Norepinephrine Transport Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Catecholamine Uptake Dopamine Uptake Azole Transmembrane Transport Serotonin Transport Quaternary Ammonium Group Transport Prostaglandin Transport Regulation Of Cell Growth Endosome To Plasma Membrane Protein Transport Transport Across Blood-brain Barrier Vitamin Transmembrane Transport Organic Anion Transmembrane Transporter Activity Neurotransmitter Transport Dopamine Transport Neurotransmitter Reuptake Cellular Detoxification Xenobiotic Transmembrane Transporter Activity Monoamine Transport Regulation Of Growth Import Into Cell Plasma Membrane Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Apical Plasma Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?