MTIF3 and CDIPT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MTIF3	CDIPT
Description		mitochondrial translational initiation factor 3	CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ribosome Binding Ribosomal Small Subunit Binding	CDP-diacylglycerol-inositol 3-phosphatidyltransferase Activity Protein Binding Transferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Diacylglycerol Binding Manganese Ion Binding Carbohydrate Binding Alcohol Binding Metal Ion Binding
	Biological Process	Translation Translational Initiation Ribosome Disassembly Mitochondrial Translational Initiation	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phospholipid Biosynthetic Process CDP-diacylglycerol Metabolic Process
Pathways		Mitochondrial translation initiation	Synthesis of PI
Drugs			scyllo-inositol
Diseases
GWAS		Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) BMI x environmental factors (excluding physical activity) interaction ( 33654129) BMI x environmental factors (including physical activity) interaction ( 33654129) Body mass index ( 20935630 25673413 28892062) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Estimated glomerular filtration rate change in renal transplantation (recipient effect) ( 30920136) Night sleep phenotypes ( 27126917) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603)	Mean platelet volume ( 27863252)
Interacting Genes		88 interacting genes: ADGRE2 APOD BCL2L1 BMP10 BPIFA1 BRICD5 CABP7 CD47 CDIPT CDS2 CGRRF1 CLDND2 CLEC7A CMTM5 COL4A5 COQ8A CTXN3 CXCL9 CYBC1 CYP4F2 EPGN FBXO7 FETUB FXYD3 FXYD6-FXYD2 HSFX1 HSFX2 HTATIP2 INSIG2 ITGB2 JAGN1 LAPTM4B LAT LDLR LHFPL5 MAPK1 MGST3 MRFAP1 MS4A1 NAT8 NDRG4 ORMDL1 ORMDL2 ORMDL3 PAXIP1 PEA15 PLN PLP1 PRH1 RPRM SCD SELENOK SERP1 SERP2 SERTM1 SIAH1 SNX2 SPANXN2 STARD4 STATH STRIT1 STX3 STX6 THBD THSD7B TMED8 TMEM109 TMEM11 TMEM128 TMEM147 TMEM176A TMEM218 TMEM239 TMEM242 TMEM243 TMEM254 TMEM42 TMEM97 TRARG1 TSPAN33 TUFM UNC50 VAMP4 VEZT VKORC1L1 YIPF6 ZDHHC15 ZNF202	60 interacting genes: APP AQP2 AQP6 ARL13B ATP6V0E1 BSND CD79A CGRRF1 CISD2 CPLX4 CYB561 CYB5R3 DARS2 EBP ELOVL4 ERGIC3 EVI2B FAM209A FCER1G FCGR2A FFAR2 FKBP7 GJB1 GOLM1 GPR101 GPR151 GPR152 GPX8 HSD17B13 IER3IP1 IGFBP6 JAGN1 KCNK1 KIR2DL3 LNX1 MFF MGST3 MS4A14 MTIF3 ODF4 PLP1 PSCA RELL2 RETREG3 RNF19B RPLP1 RTN3 SCAI SCN3B SDCBP SIGLEC12 SLC10A1 SLC10A6 SLC16A7 SLC7A1 SSMEM1 TLCD4 TMX2 UNC93A VMA21
Entrez ID		219402	10423
HPRD ID		17609	12063
Ensembl ID		ENSG00000122033	ENSG00000103502
Uniprot IDs		Q9H2K0	A8K3L7 O14735
PDB IDs		6NEQ 6NF8 6RW4 6RW5 7P2E 8QRM
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Serine Palmitoyltransferase Complex Regulation Of Transport Regulation Of Lipid Biosynthetic Process Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Synaptic Vesicle To Endosome Fusion Regulation Of Cellular Localization Granulocyte Migration Regulation Of Cholesterol Metabolic Process Regulation Of Membrane Lipid Metabolic Process Respiratory Burst After Phagocytosis Negative Regulation Of Lipid Metabolic Process Regulation Of Lipid Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Neutrophil Migration Cholesterol Import Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Cholesterol Metabolic Process Myeloid Leukocyte Migration	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Endoplasmic Reticulum Organization Plasma Membrane Identical Protein Binding Bile Acid:sodium Symporter Activity
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