TADA3 and RARA

Number of citations of the paper that reports this interaction (PubMedID 20413580)
43

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		TADA3	RARA
Description		transcriptional adaptor 3	retinoic acid receptor alpha
Image		No pdb structure
GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Transcription Factor TFTC Complex Mitotic Spindle ATAC Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Dendrite Protein-containing Complex Perinuclear Region Of Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Protein Domain Specific Binding	MRNA Regulatory Element Binding Translation Repressor Activity Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity Transcription Coactivator Binding Retinoic Acid Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Signaling Receptor Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Domain Specific Binding Chromatin DNA Binding Histone Deacetylase Binding Protein Kinase B Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding Metal Ion Binding MRNA 5'-UTR Binding Protein Kinase A Binding Alpha-actinin Binding Heterocyclic Compound Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Regulation Of DNA Repair Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Estrogen Receptor Signaling Pathway Regulation Of Protein Stability Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Regulation Of Cell Division Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Neural Tube Closure Liver Development Glandular Epithelial Cell Development Outflow Tract Septum Morphogenesis Growth Plate Cartilage Development Regulation Of DNA-templated Transcription Protein Phosphorylation Germ Cell Development Spermatogenesis Female Pregnancy Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Translation Hippocampus Development Cell Differentiation Prostate Gland Development Regulation Of Granulocyte Differentiation Negative Regulation Of Granulocyte Differentiation Embryonic Camera-type Eye Development Regulation Of Myelination Response To Estradiol Response To Retinoic Acid Negative Regulation Of Type II Interferon Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Response To Vitamin A Response To Cytokine Multicellular Organism Growth MRNA Transcription By RNA Polymerase II Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Response To Ethanol Negative Regulation Of Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Binding Ventricular Cardiac Muscle Cell Differentiation Sertoli Cell Fate Commitment Limb Development Face Development Bone Development Trachea Cartilage Development Chondroblast Differentiation Negative Regulation Of Cartilage Development Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Estrogen Stimulus Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of MiRNA Transcription
Pathways		HATs acetylate histones Ub-specific processing proteases Formation of WDR5-containing histone-modifying complexes	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis TGFBR3 expression
Drugs			Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Isotretinoin Tamibarotene LGD-1550 Trifarotene
Diseases			Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Acute myeloid leukemia (AML)
GWAS			Asthma ( 31619474)
Interacting Genes		35 interacting genes: ADPGK ANKRD12 ANKRD36B AR CCNC CEBPA CENPB EIF3J EP300 ESR1 FAM107B H3-4 HEXIM2 HSPA8 ING5 KDM1A MAGEH1 MFHAS1 NR1I2 OGT PIAS4 RARA RFX1 RXRA RXRB SAP18 SGF29 STX11 TADA2A TP53 TXLNB TXNRD2 USP5 XRCC6 ZNF7	96 interacting genes: ACTN4 AKT1 ALOX15B ALX1 ARID1A ARID5A BAG1 BBS4 BMAL1 BTG1 CCND3 CCNDBP1 CDK7 CEBPA CLOCK CNOT1 COPS2 E2F1 ESR1 FGFR1 FN1 FOXO1 GADD45G GATA2 HDAC1 HDAC3 HDAC4 HMGA1 HR IRX4 ITGB1BP2 KAT2B KDM5A KLF5 LRIF1 MAPK6 MCRS1 MDM2 MECR MED1 MED25 MED6 MMS19 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR2C1 NR2E3 NR3C1 NRBF2 NRIP1 NRIP2 NSD1 PARP1 PHF8 PIN1 PLEKHF2 PML PNRC2 POU2F1 PRAME PRDX6 PRKCA PSMC5 RXRA RXRB RXRG S100A3 SIRT1 SMARCD3 SNW1 SP1 SPEN SRC SRF STAT5B TADA3 TEKT4 THRB TNIP1 TOP2B TRIM24 TRIP4 UBE3A UBQLN1 UBR5 USP7 ZBTB16
Entrez ID		10474	5914
HPRD ID		04252	06769
Ensembl ID		ENSG00000171148	ENSG00000131759
Uniprot IDs		A0A024R2D7 A8K899 O75528	A8K840 A8MUP8 F1D8N9 P10276 Q6I9R7
PDB IDs			1DKF 1DSZ 3A9E 3KMR 3KMZ 4DQM 5K13 6XWG 7AOS 7APO 7QAA 7WQQ 9GFE 9GFI
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Nuclear Receptor Activity Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of RNA Metabolic Process Chromatin Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Coactivator Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Steroid Receptor Activity Retinoic Acid-responsive Element Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Transcription Cis-regulatory Region Binding Chromatin DNA Binding DNA Binding Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Nucleus DNA-templated Transcription Nuclear Receptor-mediated Signaling Pathway Sequence-specific DNA Binding Cellular Response To Estrogen Stimulus DNA-binding Transcription Factor Activity Intracellular Receptor Signaling Pathway MRNA Transcription Response To Estrogen Regulation Of Macromolecule Metabolic Process Hormone-mediated Signaling Pathway Enzyme Binding Positive Regulation Of Macromolecule Biosynthetic Process Retinoic Acid Receptor Signaling Pathway Histone Acetyltransferase Complex Protein-containing Complex Regulation Of MiRNA Transcription	Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Nuclear Retinoic Acid Receptor Binding Nuclear Receptor Binding Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Metabolic Process Hormone-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Response To Hormone Nuclear Retinoid X Receptor Binding Rhythmic Process Transcription Regulator Complex Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Transcription Coactivator Activity Retinoic Acid Receptor Signaling Pathway Sequence-specific DNA Binding Regulation Of Developmental Process Chromatin Binding Nuclear Estrogen Receptor Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?