TADA3 and TXNRD2

Number of citations of the paper that reports this interaction (PubMedID 20413580)
43

Data Source:
BioGRID (two hybrid)

		TADA3	TXNRD2
Description		transcriptional adaptor 3	thioredoxin reductase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Transcription Factor TFTC Complex Mitotic Spindle ATAC Complex	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Axon Dendrite Neuronal Cell Body
	Molecular Function	Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Protein Domain Specific Binding	Thioredoxin-disulfide Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, NAD(P) As Acceptor Protein Homodimerization Activity Protein-containing Complex Binding Flavin Adenine Dinucleotide Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Regulation Of DNA Repair Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Estrogen Receptor Signaling Pathway Regulation Of Protein Stability Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Regulation Of Cell Division Regulation Of Cell Cycle	Response To Oxygen Radical Response To Oxidative Stress Response To Selenium Ion Cell Redox Homeostasis Response To Hyperoxia Cellular Oxidant Detoxification
Pathways		HATs acetylate histones Ub-specific processing proteases Formation of WDR5-containing histone-modifying complexes	Detoxification of Reactive Oxygen Species
Drugs			Motexafin gadolinium
Diseases
GWAS			Glaucoma ( 30054594 31959993) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary angle closure) ( 22922875) Glaucoma (primary open-angle) ( 26752265 29891935 33627673) Intraocular pressure ( 29785010 30054594 31959993) Lean body mass ( 28552196) Staphylococcus aureus infection ( 24847357)
Interacting Genes		35 interacting genes: ADPGK ANKRD12 ANKRD36B AR CCNC CEBPA CENPB EIF3J EP300 ESR1 FAM107B H3-4 HEXIM2 HSPA8 ING5 KDM1A MAGEH1 MFHAS1 NR1I2 OGT PIAS4 RARA RFX1 RXRA RXRB SAP18 SGF29 STX11 TADA2A TP53 TXLNB TXNRD2 USP5 XRCC6 ZNF7	8 interacting genes: BCAS2 CFTR GTF2H1 NCOA2 NCOA6 NCOR1 PSMC3 TADA3
Entrez ID		10474	10587
HPRD ID		04252	18519
Ensembl ID		ENSG00000171148	ENSG00000184470
Uniprot IDs		A0A024R2D7 A8K899 O75528	A0A096LPD9 E7EWK1 Q9NNW7
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Nuclear Receptor Activity Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of RNA Metabolic Process Chromatin Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Coactivator Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Steroid Receptor Activity Retinoic Acid-responsive Element Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Transcription Cis-regulatory Region Binding Chromatin DNA Binding DNA Binding Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Nucleus DNA-templated Transcription Nuclear Receptor-mediated Signaling Pathway Sequence-specific DNA Binding Cellular Response To Estrogen Stimulus DNA-binding Transcription Factor Activity Intracellular Receptor Signaling Pathway MRNA Transcription Response To Estrogen Regulation Of Macromolecule Metabolic Process Hormone-mediated Signaling Pathway Enzyme Binding Positive Regulation Of Macromolecule Biosynthetic Process Retinoic Acid Receptor Signaling Pathway Histone Acetyltransferase Complex Protein-containing Complex Regulation Of MiRNA Transcription	Nuclear Receptor Binding Nuclear Thyroid Hormone Receptor Binding Transcription Coactivator Activity Locomotor Rhythm Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Chromatin Binding Circadian Behavior Rhythmic Behavior Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleotide-excision Repair Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Initiation Nucleoplasm Positive Regulation Of Biosynthetic Process Positive Regulation Of Anion Channel Activity Spindle Assembly Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Monoatomic Anion Transport Cellular Response To Thyroglobulin Triiodothyronine Positive Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Enamel Mineralization Circadian Rhythm Mitotic Spindle Transepithelial Water Transport Hormone-mediated Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Response To Thyroglobulin Triiodothyronine Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Tooth Mineralization Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Proteasome-activating Activity Spindle Organization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization
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