EIF3F and SHBG

Number of citations of the paper that reports this interaction (PMID 15862967)
1

Data Source:
HPRD (two hybrid)

		EIF3F	SHBG
Gene Name		eukaryotic translation initiation factor 3, subunit F	sex hormone-binding globulin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Extracellular Region Extracellular Vesicular Exosome
	Molecular Function	Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Translation Initiation Factor Binding	Androgen Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Proteolysis Gene Expression Protein Deubiquitination Cellular Protein Metabolic Process	Primary Spermatocyte Growth
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS		Depression (quantitative trait) ( 20800221)	Androgen levels ( 22936694) Protein quantitative trait loci ( 18464913) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597)
Protein-Protein Interactions		17 interactors: APP ATXN1 CDK11A CDK11B CDK19 DKC1 EEF1A1 EIF3M FBXO32 HAX1 HNRNPK HTR2A MTOR PTN SHBG SMAD9 UBC	62 interactors: A2M ACPP ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5A1 AZGP1 C9orf24 CD177 CECR5 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A
Entrez ID		8665	6462
HPRD ID		04887	01646
Ensembl ID		ENSG00000175390	ENSG00000129214
Uniprot IDs		B4DEW9 O00303	B0FWH2 B4DYU0 I3L1J1 I3L2X4 P04278
PDB IDs			1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Biosynthetic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transcription, DNA-templated Learning Or Memory Positive Regulation Of Macromolecule Biosynthetic Process Cognition Positive Regulation Of Gene Expression Response To Abiotic Stimulus Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Learning Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Cell Growth Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Regulation Of Transcription, DNA-templated Protein Phosphorylation Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Adult Behavior Regulation Of RNA Biosynthetic Process Single-organism Behavior Regulation Of RNA Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Cell Cycle Regulation Of Phosphorus Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Processing Cellular Response To Growth Factor Stimulus Cell Death Death Regulation Of Protein Phosphorylation Behavior Response To Growth Factor Regulation Of Carbohydrate Utilization Primary Spermatocyte Growth Cellular Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Translation Visual Learning Visual Behavior Response To Organic Substance Response To Hypoxia	Platelet Activation Extracellular Matrix Disassembly Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cellular Response To Zinc Ion Endocytosis Vesicle-mediated Transport Response To Wounding Transport Endosomal Transport Cell Activation Response To Zinc Ion Cell Projection Organization Immune System Process MRNA Transcription From RNA Polymerase II Promoter Glucose Metabolic Process MRNA Transcription Neuron Projection Development Movement Of Cell Or Subcellular Component Cellular Response To Cadmium Ion Regulation Of Water Loss Via Skin Formation Of Translation Preinitiation Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cell Morphogenesis Involved In Differentiation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Receptor-mediated Endocytosis Hexose Metabolic Process Neuron Development Extracellular Matrix Organization Viral Process Cytoplasmic Sequestering Of Protein Regulation Of Defense Response To Virus By Virus Extracellular Structure Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Axon Development Antigen Processing And Presentation Of Peptide Antigen Locomotion Negative Regulation Of Growth Monosaccharide Metabolic Process Sperm Entry Negative Regulation Of T Cell Migration Contractile Actin Filament Bundle Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Positive Regulation Of Late Endosome To Lysosome Transport Sorbitol Catabolic Process L-xylitol Metabolic Process L-xylitol Catabolic Process Fructose Biosynthetic Process
Tagcloud ?		4g abrogated consequent eif3g eif4g enhancement eukaryotic initiation interacting interaction mtorc1 pabp paip1 phosphorylate phosphorylates poly pp242 rapamycin ribosomal s6 s6k s6k1 shrna simultaneous stimulate stimulates tail translation	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm grm1 grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shr symbol wtc zi
Tagcloud (Difference) ?		4g abrogated consequent eif3g eif4g enhancement eukaryotic initiation interacting interaction mtorc1 pabp paip1 phosphorylate phosphorylates poly pp242 rapamycin ribosomal s6 s6k s6k1 shrna simultaneous stimulate stimulates tail translation	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm grm1 grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shr symbol wtc zi
Tagcloud (Intersection) ?