EIF3F and MYDGF

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EIF3F	MYDGF
Description		eukaryotic translation initiation factor 3 subunit F	myeloid derived growth factor
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Synapse Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus
	Molecular Function	Translation Initiation Factor Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Metallopeptidase Activity Hydrolase Activity Translation Initiation Factor Binding Identical Protein Binding Deubiquitinase Activity Metal-dependent Deubiquitinase Activity	Protein Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Proteolysis IRES-dependent Viral Translational Initiation	Angiogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	XBP1(S) activates chaperone genes
Drugs		Quercetin
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depression (quantitative trait) ( 20800221) Malaria ( 31844061) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		47 interacting genes: AGR2 APP ATXN1 BTG3 C1orf216 CCDC120 CCDC196 CDC42 CDK11B CDK19 CDSN COL1A2 DKC1 EEF1A1 EIF3M EML2 ERCC6 FBXO32 HAX1 HGS HNRNPK HTR2A KLHL20 LCOR MCPH1 MKRN2 MSH4 MTOR MYDGF MYOZ1 NUP54 OGT PBX4 PKN1 POGZ POU6F2 PTN RABIF RIN1 RPS6KB1 RTP5 SHBG SMAD9 SUOX TEX56P TIMM10B WASHC1	13 interacting genes: ACOT13 BAG6 EIF3F HPCA HPCAL1 LCN2 MDM2 NCALD SGTA SGTB UBQLN1 UBQLN2 UBQLN4
Entrez ID		8665	56005
HPRD ID		04887	08415
Ensembl ID		ENSG00000175390	ENSG00000074842
Uniprot IDs		O00303	Q969H8
PDB IDs		3J8B 3J8C 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN	6O6W 6SVK 6SVL
Enriched GO Terms of Interacting Partners?		Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glycolytic Process Negative Regulation Of TORC2 Signaling Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of ATP Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Nutrient Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Protein Localization Positive Regulation Of Translational Initiation Memory Positive Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Pseudopodium Assembly Skin Morphogenesis Regulation Of TORC2 Signaling Regulation Of Supramolecular Fiber Organization TORC2 Signaling Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Gliogenesis Positive Regulation Of TORC1 Signaling TORC1 Signaling Organelle Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Learning Protein Trimerization Positive Regulation Of Transcription By RNA Polymerase III Protein Tyrosine Kinase Activator Activity Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Regulation Of Insulin Receptor Signaling Pathway Regulation Of Gene Expression Response To Auditory Stimulus Mitochondrial Intermembrane Space	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Identical Protein Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process TRC Complex Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Cellular Response To Stress Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Protein Targeting To Membrane Regulation Of Receptor Internalization Response To Endoplasmic Reticulum Stress Autophagosome Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Stress Macromolecule Catabolic Process Protein Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Receptor-mediated Endocytosis Cellular Response To Hypoxia Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Cellular Response To Decreased Oxygen Levels Negative Regulation Of Proteolysis Cellular Response To Oxygen Levels Positive Regulation Of Protein Metabolic Process Protein Insertion Into ER Membrane Response To Iron Ion Molecular Adaptor Activity Regulation Of Macroautophagy Protein Targeting Establishment Of Protein Localization To Membrane Regulation Of Protein Metabolic Process Hsp70 Protein Binding
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