EIF3F and CDK19

Number of citations of the paper that reports this interaction (PubMedID 12446680)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		EIF3F	CDK19
Description		eukaryotic translation initiation factor 3 subunit F	cyclin dependent kinase 19
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Synapse Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm CKM Complex
	Molecular Function	Translation Initiation Factor Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Metallopeptidase Activity Hydrolase Activity Translation Initiation Factor Binding Identical Protein Binding Deubiquitinase Activity Metal-dependent Deubiquitinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Proteolysis IRES-dependent Viral Translational Initiation	Positive Regulation Of Apoptotic Process Regulation Of Cell Cycle Cellular Response To Lipopolysaccharide
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs		Quercetin
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depression (quantitative trait) ( 20800221) Malaria ( 31844061) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	General risk tolerance (MTAG) ( 30643258) Myeloperoxidase-DNA complexes ( 33717105) Zinc levels ( 26025379)
Interacting Genes		47 interacting genes: AGR2 APP ATXN1 BTG3 C1orf216 CCDC120 CCDC196 CDC42 CDK11B CDK19 CDSN COL1A2 DKC1 EEF1A1 EIF3M EML2 ERCC6 FBXO32 HAX1 HGS HNRNPK HTR2A KLHL20 LCOR MCPH1 MKRN2 MSH4 MTOR MYDGF MYOZ1 NUP54 OGT PBX4 PKN1 POGZ POU6F2 PTN RABIF RIN1 RPS6KB1 RTP5 SHBG SMAD9 SUOX TEX56P TIMM10B WASHC1	7 interacting genes: BCL6 EIF3F PRMT5 SMARCA4 SRSF7 SUZ12 WDR77
Entrez ID		8665	23097
HPRD ID		04887	07627
Ensembl ID		ENSG00000175390	ENSG00000155111
Uniprot IDs		O00303	B4DUB1 F6QTA4 I6W807 Q9BWU1
PDB IDs		3J8B 3J8C 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glycolytic Process Negative Regulation Of TORC2 Signaling Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of ATP Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Nutrient Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Protein Localization Positive Regulation Of Translational Initiation Memory Positive Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Pseudopodium Assembly Skin Morphogenesis Regulation Of TORC2 Signaling Regulation Of Supramolecular Fiber Organization TORC2 Signaling Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Gliogenesis Positive Regulation Of TORC1 Signaling TORC1 Signaling Organelle Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Learning Protein Trimerization Positive Regulation Of Transcription By RNA Polymerase III Protein Tyrosine Kinase Activator Activity Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Regulation Of Insulin Receptor Signaling Pathway Regulation Of Gene Expression Response To Auditory Stimulus Mitochondrial Intermembrane Space	Negative Regulation Of Gene Expression, Epigenetic Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Developmental Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RSC-type Complex Methylosome Negative Regulation Of Gene Expression Regulation Of RNA Splicing Methyl-CpG Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Chromatin Remodeling Negative Regulation Of RNA Metabolic Process Negative Regulation Of Cell Differentiation Positive Regulation Of RNA Splicing Spliceosomal SnRNP Assembly Transcription Corepressor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Regulation Of MRNA Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle DNA Replication P53 Binding Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Oocyte Axis Specification Chromatin DNA Binding Cysteine-type Deubiquitinase Activity Positive Regulation Of Cell Development Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Plasma Cell Differentiation Peptidyl-arginine N-methylation Regulation Of RNA Metabolic Process Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Mitotic Cell Cycle DNA Replication Isotype Switching To IgE Isotypes Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of T Cell Differentiation Chromatin Binding Regulation Of Mitotic Cell Cycle Intronic Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Biosynthetic Process Protein-containing Complex Assembly Cysteine-type Peptidase Activity
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