EIF3F and EIF3M

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid, affinity chromatography technology, biochemical, biochemical)
HPRD (two hybrid)

		EIF3F	EIF3M
Gene Name		eukaryotic translation initiation factor 3, subunit F	eukaryotic translation initiation factor 3, subunit M
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Translation Initiation Factor Binding	Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Proteolysis Gene Expression Protein Deubiquitination Cellular Protein Metabolic Process	Formation Of Translation Preinitiation Complex Cytoplasmic Translational Initiation Translational Initiation Regulation Of Translational Initiation
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS		Depression (quantitative trait) ( 20800221)
Protein-Protein Interactions		17 interactors: APP ATXN1 CDK11A CDK11B CDK19 DKC1 EEF1A1 EIF3M FBXO32 HAX1 HNRNPK HTR2A MTOR PTN SHBG SMAD9 UBC	4 interactors: APP EIF3F EXOSC10 SRPK1
Entrez ID		8665	10480
HPRD ID		04887	09969
Ensembl ID		ENSG00000175390
Uniprot IDs		B4DEW9 O00303	B4E2Q4 Q7L2H7
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Biosynthetic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transcription, DNA-templated Learning Or Memory Positive Regulation Of Macromolecule Biosynthetic Process Cognition Positive Regulation Of Gene Expression Response To Abiotic Stimulus Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Learning Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Cell Growth Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Regulation Of Transcription, DNA-templated Protein Phosphorylation Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Adult Behavior Regulation Of RNA Biosynthetic Process Single-organism Behavior Regulation Of RNA Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Cell Cycle Regulation Of Phosphorus Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Processing Cellular Response To Growth Factor Stimulus Cell Death Death Regulation Of Protein Phosphorylation Behavior Response To Growth Factor Regulation Of Carbohydrate Utilization Primary Spermatocyte Growth Cellular Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Translation Visual Learning Visual Behavior Response To Organic Substance Response To Hypoxia	MRNA Metabolic Process RNA Processing Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Synaptic Growth At Neuromuscular Junction Gene Expression Collateral Sprouting In Absence Of Injury Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Translation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Nuclear MRNA Surveillance Ribonucleoprotein Complex Biogenesis RNA Surveillance Neuron Remodeling Sperm Chromatin Condensation Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome Intracellular MRNA Localization MRNA Processing Regulation Of Gene Expression Dosage Compensation RRNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Maturation Of 5.8S RRNA Cellular Copper Ion Homeostasis Histone MRNA Metabolic Process Positive Regulation Of Viral Genome Replication Formation Of Translation Preinitiation Complex Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Spermatid Nucleus Differentiation Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Sexual Reproduction Innate Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Viral Genome Replication Regulation Of Cell Cycle G2/M Phase Transition
Tagcloud ?		4g abrogated consequent eif3g eif4g enhancement eukaryotic initiation interacting interaction mtorc1 pabp paip1 phosphorylate phosphorylates poly pp242 rapamycin ribosomal s6 s6k s6k1 shrna simultaneous stimulate stimulates tail translation	2alpha 3j 4b activating caspases cisplatin cleavage cleaved cleaving composed dnase eif3a eif3g eif4g eukaryotic induces initiation machinery nucleus rapidly regulate slrd strong subunits t24 terminus translation translocated
Tagcloud (Difference) ?		4g abrogated consequent enhancement interacting interaction mtorc1 pabp paip1 phosphorylate phosphorylates poly pp242 rapamycin ribosomal s6 s6k s6k1 shrna simultaneous stimulate stimulates tail	2alpha 3j 4b activating caspases cisplatin cleavage cleaved cleaving composed dnase eif3a induces machinery nucleus rapidly regulate slrd strong subunits t24 terminus translocated
Tagcloud (Intersection) ?		eif3g eif4g eukaryotic initiation translation