MPL and ATXN2L

Number of citations of the paper that reports this interaction (PubMedID 11784712)
0

Data Source:
HPRD (in vivo)

		MPL	ATXN2L
Description		MPL proto-oncogene, thrombopoietin receptor	ataxin 2 like
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Nuclear Membrane Neuronal Cell Body	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Nuclear Speck
	Molecular Function	Cytokine Receptor Activity Protein Binding Thrombopoietin Receptor Activity	RNA Binding MRNA Binding Protein Binding Cadherin Binding
	Biological Process	Neutrophil Homeostasis Platelet Formation Monocyte Homeostasis Thrombopoietin-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Cellular Response To Hypoxia Positive Regulation Of Platelet Formation Eosinophil Homeostasis Basophil Homeostasis	MRNA Metabolic Process Stress Granule Assembly
Pathways		Platelet Aggregation (Plug Formation)
Drugs		Romiplostim SB-559448 Eltrombopag Thrombopoietin Avatrombopag Lusutrombopag
Diseases		Congenital amegakaryocytic thrombocytopenia (CAMT)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29679657) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 20935630 28448500 28552196) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Crohn's disease ( 28067908) Educational attainment ( 23722424 25201988) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Extremely high intelligence ( 29520040) Hand grip strength ( 29691431) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Left-handedness ( 32989287) Pediatric autoimmune diseases ( 26301688) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		9 interacting genes: ANKRA2 ATXN2L IRS2 JAK2 PTPN11 SHC1 SOCS1 THPO YWHAQ	42 interacting genes: ATXN1 BOLL CEBPA EPOR HADHA HOXA1 KRTAP12-4 MIR1-1 MIR10B MIR128-1 MIR128-2 MIR15B MIR16-2 MIR17 MIR19A MIR200C MIR205 MIR20B MIR21 MIR214 MIR25 MIR31 MIR34A MIR34B MIR363 MIR7-1 MIR7-2 MIR7-3 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MPL OGT
Entrez ID		4352	11273
HPRD ID		01161	06394
Ensembl ID		ENSG00000117400	ENSG00000168488
Uniprot IDs		P40238	H3BUF6 Q8WWM7
PDB IDs		8G04
Enriched GO Terms of Interacting Partners?		Insulin Receptor Binding Protein Kinase Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Thrombopoietin-mediated Signaling Pathway Myeloid Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptide Hormone Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Phosphatidylinositol 3-kinase Binding Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Cell Activation Cytokine-mediated Signaling Pathway Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Hormone Secretion Megakaryocyte Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Insulin Secretion Neuron Projection Regeneration Hemopoiesis Regulation Of Lymphocyte Activation Positive Regulation Of ERK1 And ERK2 Cascade 14-3-3 Protein Binding Regulation Of Peptide Hormone Secretion Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of D-glucose Import Epithelial Cell Migration Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Lipid Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of D-glucose Transmembrane Transport Phosphotyrosine Residue Binding Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Activation Regulation Of Hormone Secretion Regulation Of Protein Secretion Positive Regulation Of T Cell Activation Signal Transduction Regulation Of MAPK Cascade Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of D-glucose Import Histone H3Y41 Kinase Activity Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway Positive Regulation Of Secretion By Cell	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA Destabilization Negative Regulation Of Translation RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Positive Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Negative Regulation Of Cell Migration Regulation Of Translation Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Extracellular Space Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Proliferation Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Connective Tissue Replacement Negative Regulation Of Signal Transduction
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