RUNX1 and EFNA2

Number of citations of the paper that reports this interaction (PMID 10207087)
23

Data Source:
BioGRID (pull down)

		RUNX1	EFNA2
Gene Name		runt-related transcription factor 1	ephrin-A2
Image
Gene Ontology Annotations	Cellular Component	Basement Membrane Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle	Extracellular Region Plasma Membrane Anchored Component Of Membrane Neuromuscular Junction Perikaryon
	Molecular Function	Regulatory Region DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Calcium Ion Binding Protein Binding ATP Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Repressing Transcription Factor Binding	Ephrin Receptor Binding
	Biological Process	Skeletal System Development In Utero Embryonic Development Liver Development Myeloid Progenitor Cell Differentiation Transcription, DNA-templated Central Nervous System Development Regulation Of Signal Transduction Hemopoiesis Myeloid Cell Differentiation Negative Regulation Of Granulocyte Differentiation Positive Regulation Of Granulocyte Differentiation Hair Follicle Morphogenesis Embryonic Hemopoiesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Behavioral Response To Pain Peripheral Nervous System Neuron Development Definitive Hemopoiesis Regulation Of Hair Follicle Cell Proliferation Hematopoietic Stem Cell Proliferation Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Progesterone Secretion	Cell-cell Signaling Axon Guidance Olfactory Bulb Development Osteoclast Differentiation Bone Remodeling Ephrin Receptor Signaling Pathway
Pathways			EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS		Esophageal cancer ( 21642993) Immune response to smallpox vaccine (IL-6) ( 22542470) Phospholipid levels (plasma) ( 21829377) Preeclampsia ( 23551011)
Protein-Protein Interactions		46 interactors: AES AR CBFA2T2 CBFA2T3 CBFB CCND1 CCND2 CCND3 CDK1 CDK6 CEBPA CEBPB COPRS CTBP2 DNMT1 EFNA2 ELF2 ELF4 EP300 ETS1 FOS FOXP3 HDAC1 HDAC3 HIPK1 HIPK2 JUN KAT6A KAT6B MYOD1 NCOR1 NCOR2 PAX5 PRMT1 RBM14 SPEN STUB1 SUV39H1 TAZ TLE1 TLE2 UBE2L6 UXT VDR WWTR1 YAP1	6 interactors: ADAM10 EPHA2 EPHA3 EPHA5 RUNX1 ZHX1
Entrez ID		861	1943
HPRD ID		01043	04132
Ensembl ID		ENSG00000159216	ENSG00000099617
Uniprot IDs		Q01196	O43921
PDB IDs		1CMO 1CO1 1E50 1H9D 1LJM	2WO3
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Developmental Process System Development Regulation Of Cellular Process Cell Differentiation Multicellular Organismal Development Anatomical Structure Development Notch Signaling Pathway Chromatin Organization Cellular Metabolic Process Chromatin Modification Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cell Differentiation Response To Organic Substance	Ephrin Receptor Signaling Pathway Neuron Development Axon Guidance Neuron Differentiation Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Generation Of Neurons Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Neurogenesis Cell Morphogenesis Involved In Differentiation Cell Development Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Rho GTPase Activity Peptidyl-tyrosine Phosphorylation Nervous System Development Regulation Of Rho Protein Signal Transduction Cell Morphogenesis Anatomical Structure Morphogenesis Cell Projection Organization Locomotion Protein Phosphorylation Developmental Process Movement Of Cell Or Subcellular Component Regulation Of Ras GTPase Activity Notochord Cell Development Constitutive Protein Ectodomain Proteolysis Regulation Of Cell Adhesion Regulation Of Ras Protein Signal Transduction Response To External Stimulus Positive Regulation Of Progesterone Secretion Phosphorylation Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Organization Regulation Of GTPase Activity Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching PMA-inducible Membrane Protein Ectodomain Proteolysis Axial Mesoderm Formation Regulation Of Progesterone Secretion System Development Regulation Of Hair Follicle Cell Proliferation Peptidyl-amino Acid Modification Notochord Formation
Tagcloud ?		1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx2 runx3 syndromes unmethylated	16p13 16q12 19p13 21q21 affymetrix agar arrays cd133 cd133high cd133low colonies die extracranial gains genotyping heterozygosity il2rgammac initiating injections lethal nb neurosphere neurospheres orthotopic persist relapses soft tics uncontrolled
Tagcloud (Difference) ?		1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx2 runx3 syndromes unmethylated	16p13 16q12 19p13 21q21 affymetrix agar arrays cd133 cd133high cd133low colonies die extracranial gains genotyping heterozygosity il2rgammac initiating injections lethal nb neurosphere neurospheres orthotopic persist relapses soft tics uncontrolled
Tagcloud (Intersection) ?