EFNA2 and EPHA3

Number of citations of the paper that reports this interaction (PMID 9751130)
7

Data Source:
HPRD (in vitro, in vivo)

		EFNA2	EPHA3
Gene Name		ephrin-A2	EPH receptor A3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Anchored Component Of Membrane Neuromuscular Junction Perikaryon	Extracellular Region Early Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Ephrin Receptor Binding	GPI-linked Ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	Cell-cell Signaling Axon Guidance Olfactory Bulb Development Osteoclast Differentiation Bone Remodeling Ephrin Receptor Signaling Pathway	Cell Adhesion Axon Guidance Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Signaling Pathway Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Retinoic Acid Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS			Orofacial clefts ( 22863734)
Protein-Protein Interactions		6 interactors: ADAM10 EPHA2 EPHA3 EPHA5 RUNX1 ZHX1	20 interactors: ABL1 ADAM10 CDKN2A CRK EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 FYN PIM1 RBM18 RUFY1 RUFY2 SRC SRPK1 STAT3 TP53
Entrez ID		1943	2042
HPRD ID		04132	01555
Ensembl ID		ENSG00000099617	ENSG00000044524
Uniprot IDs		O43921	C9JXA2 P29320 Q6P4R6
PDB IDs		2WO3	2GSF 2QO2 2QO7 2QO9 2QOB 2QOC 2QOD 2QOF 2QOI 2QOK 2QOL 2QON 2QOO 2QOQ 3DZQ 3FXX 3FY2 4G2F 4GK2 4GK3 4GK4
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Neuron Development Axon Guidance Neuron Differentiation Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Generation Of Neurons Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Neurogenesis Cell Morphogenesis Involved In Differentiation Cell Development Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Rho GTPase Activity Peptidyl-tyrosine Phosphorylation Nervous System Development Regulation Of Rho Protein Signal Transduction Cell Morphogenesis Anatomical Structure Morphogenesis Cell Projection Organization Locomotion Protein Phosphorylation Developmental Process Movement Of Cell Or Subcellular Component Regulation Of Ras GTPase Activity Notochord Cell Development Constitutive Protein Ectodomain Proteolysis Regulation Of Cell Adhesion Regulation Of Ras Protein Signal Transduction Response To External Stimulus Positive Regulation Of Progesterone Secretion Phosphorylation Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Organization Regulation Of GTPase Activity Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching PMA-inducible Membrane Protein Ectodomain Proteolysis Axial Mesoderm Formation Regulation Of Progesterone Secretion System Development Regulation Of Hair Follicle Cell Proliferation Peptidyl-amino Acid Modification Notochord Formation	Ephrin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Differentiation Neuron Projection Development Cell Projection Morphogenesis Generation Of Neurons Cell Part Morphogenesis Neurogenesis Neuron Development Cell Development Cell Morphogenesis Movement Of Cell Or Subcellular Component Cell Projection Organization Locomotion Nervous System Development Response To External Stimulus Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Cell Differentiation Signal Transduction Developmental Process Regulation Of Cell Adhesion Signaling Cell Communication Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Phosphorylation Multicellular Organismal Development Regulation Of Cell-cell Adhesion Regulation Of Cellular Component Organization Anatomical Structure Development Regulation Of Cell Proliferation Regulation Of Protein Phosphorylation System Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Cycle Positive Regulation Of Phosphorylation
Tagcloud ?		16p13 16q12 19p13 21q21 affymetrix agar arrays cd133 cd133high cd133low colonies die extracranial gains genotyping heterozygosity il2rgammac initiating injections lethal nb neurosphere neurospheres orthotopic persist relapses soft tics uncontrolled	arid2 asxl3 cdkn2a clonal clone dipyrimidine driver extension founding geographic hypermutator lacked mel9 melanoma mll2 nras phosphatases ptprb ptprd ptprt rb1 signature strikingly subclonal subclones suppressors transitions truncation wgs
Tagcloud (Difference) ?		16p13 16q12 19p13 21q21 affymetrix agar arrays cd133 cd133high cd133low colonies die extracranial gains genotyping heterozygosity il2rgammac initiating injections lethal nb neurosphere neurospheres orthotopic persist relapses soft tics uncontrolled	arid2 asxl3 cdkn2a clonal clone dipyrimidine driver extension founding geographic hypermutator lacked mel9 melanoma mll2 nras phosphatases ptprb ptprd ptprt rb1 signature strikingly subclonal subclones suppressors transitions truncation wgs
Tagcloud (Intersection) ?