EFNA2 and ADAM10

Number of citations of the paper that reports this interaction (PubMedID 10958785)
0

Data Source:
HPRD (in vivo, in vitro)

		EFNA2	ADAM10
Description		ephrin A2	ADAM metallopeptidase domain 10
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuromuscular Junction Perikaryon Side Of Membrane	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Golgi-associated Vesicle Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Postsynaptic Density Membrane Clathrin-coated Vesicle Axon Dendrite Cytoplasmic Vesicle Specific Granule Membrane Cell Projection Pore Complex Extracellular Exosome Anchoring Junction Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum Synaptic Membrane Tetraspanin-enriched Microdomain Glutamatergic Synapse
	Molecular Function	Protein Binding Ephrin Receptor Binding	Endopeptidase Activity Metalloendopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Protein Kinase Binding Protein Homodimerization Activity Metal Ion Binding Metallodipeptidase Activity Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
	Biological Process	Cell-cell Signaling Axon Guidance Olfactory Bulb Development Osteoclast Differentiation Bone Remodeling Ephrin Receptor Signaling Pathway	In Utero Embryonic Development Proteolysis Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Regulation Of Notch Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of T Cell Chemotaxis Protein Processing Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Adherens Junction Organization Response To Tumor Necrosis Factor Epidermal Growth Factor Receptor Ligand Maturation Monocyte Activation Amyloid Precursor Protein Catabolic Process Pore Complex Assembly Constitutive Protein Ectodomain Proteolysis Cochlea Development Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynapse Organization Regulation Of Postsynapse Organization Protein Catabolic Process At Postsynapse Signaling Receptor Ligand Precursor Processing Regulation Of Vasculature Development Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	Collagen degradation Degradation of the extracellular matrix Signaling by EGFR Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Neutrophil degranulation Post-translational protein phosphorylation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Amyloid fiber formation
Drugs			XL784
Diseases
GWAS		Response to selenium supplementation (change in plasma selenium concentration) ( 33382417)	Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 33589840) Apolipoprotein A1 levels ( 32203549) Chronotype ( 30696823) Diffusing capacity of carbon monoxide ( 30694715) Family history of Alzheimer's disease ( 30617256) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355) Metabolite levels ( 23823483) Schizophrenia ( 30285260)
Interacting Genes		5 interacting genes: ADAM10 EPHA2 EPHA3 EPHA5 ZHX1	7 interacting genes: AXL DLL1 EFNA1 EFNA2 EPHA3 SH3D19 TGFA
Entrez ID		1943	102
HPRD ID		04132	03723
Ensembl ID		ENSG00000099617	ENSG00000137845
Uniprot IDs		O43921	O14672
PDB IDs		2WO3	6BDZ 6BE6 8ESV
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Signaling Pathway GPI-linked Ephrin Receptor Activity Regulation Of Cellular Localization Protein Tyrosine Kinase Activity Regulation Of GTPase Activity Regulation Of Protein Localization To Cell Periphery Transmembrane-ephrin Receptor Activity Regulation Of Protein Localization To Membrane Regulation Of Protein Localization Positive Regulation Of Protein Localization To Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Dendrite Positive Regulation Of Protein Localization To Cell Periphery Protein Kinase Activity Positive Regulation Of Protein Localization To Membrane Constitutive Protein Ectodomain Proteolysis Notochord Cell Development Regulation Of Catalytic Activity Kinase Activity Regulation Of Protein Localization To Plasma Membrane Epidermal Growth Factor Receptor Ligand Maturation Enzyme-linked Receptor Protein Signaling Pathway Axial Mesoderm Formation Fasciculation Of Motor Neuron Axon Cell Surface Receptor Signaling Pathway Protein Catabolic Process At Postsynapse Negative Regulation Of Lymphangiogenesis Notochord Formation Fasciculation Of Sensory Neuron Axon Regulation Of Cell Adhesion Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Neuron Projection Guidance Axon Guidance Notochord Morphogenesis Pericyte Cell Differentiation Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Cellular Component Organization Lens Fiber Cell Morphogenesis Metallodipeptidase Activity Regulation Of Cell Junction Assembly Tetraspanin-enriched Microdomain Positive Regulation Of CREB Transcription Factor Activity Monocyte Activation Leading Edge Membrane Positive Regulation Of Bicellular Tight Junction Assembly Cell Projection Regulation Of Vasculature Development Pore Complex	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Cell Surface Receptor Signaling Pathway Neuron Projection Guidance Axon Guidance Substrate Adhesion-dependent Cell Spreading Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Endocytosis Regulation Of Developmental Process Regulation Of Cell Adhesion Notch Signaling Pathway Involved In Arterial Endothelial Cell Fate Commitment Cerebellar Molecular Layer Formation Regulation Of Cell Differentiation Leukocyte Differentiation Tissue Remodeling Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Fasciculation Of Motor Neuron Axon Endothelial Tip Cell Fate Specification Cerebellar Purkinje Cell Layer Structural Organization Positive Regulation Of Cellular Component Organization Signal Transduction Protein Kinase Activity Protein Tyrosine Kinase Activity Plasma Membrane Neuron Projection Development Notochord Formation Endocardial Cushion To Mesenchymal Transition Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Side Of Membrane Fasciculation Of Sensory Neuron Axon Receptor Ligand Activity Negative Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Compartment Pattern Specification Lateral Inhibition Blood Vessel Endothelial Cell Fate Specification Endothelial Cell Fate Specification Regulation Of Vesicle-mediated Transport Positive Regulation Of Skeletal Muscle Tissue Growth Loop Of Henle Development Somite Specification Positive Regulation Of Endocytosis Positive Regulation Of Pinocytosis Kinase Activity Neutrophil Clearance Cell-substrate Adhesion
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