AQP1 and CCNDBP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AQP1	CCNDBP1
Description		aquaporin 1 (Colton blood group)	cyclin D1 binding protein 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Brush Border Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Axon Brush Border Membrane Nuclear Membrane Sarcolemma Apical Part Of Cell Extracellular Exosome Ankyrin-1 Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	Intracellularly CGMP-activated Cation Channel Activity Potassium Channel Activity Water Transmembrane Transporter Activity Protein Binding Ammonium Channel Activity Potassium Ion Transmembrane Transporter Activity Glycerol Transmembrane Transporter Activity Water Channel Activity Channel Activity Transmembrane Transporter Activity Nitric Oxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transporter Activity Identical Protein Binding Ephrin Receptor Binding Hydrogen Peroxide Channel Activity	Protein Binding
	Biological Process	Renal Water Homeostasis Glomerular Filtration Renal Water Transport Potassium Ion Transport Water Transport Cell Volume Homeostasis Hyperosmotic Response Intracellular Water Homeostasis Fibroblast Migration Positive Regulation Of Fibroblast Migration Carbon Dioxide Transport Glycerol Transmembrane Transport Cell Migration Sensory Perception Of Pain Cellular Homeostasis CGMP-mediated Signaling Lateral Ventricle Development Pancreatic Juice Secretion Nitric Oxide Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Secretion By Cell Cerebrospinal Fluid Secretion Secretory Granule Organization Cellular Response To UV Transepithelial Water Transport Carbon Dioxide Transmembrane Transport Wound Healing Odontogenesis Negative Regulation Of Apoptotic Process Lipid Digestion Positive Regulation Of Angiogenesis Positive Regulation Of Saliva Secretion Positive Regulation Of Fibroblast Proliferation Camera-type Eye Morphogenesis Defense Response To Gram-negative Bacterium Multicellular Organismal-level Water Homeostasis Corticotropin Secretion Establishment Of Localization In Cell Transmembrane Transport Renal Water Absorption Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Cellular Response To Copper Ion Cellular Response To Mercury Ion Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Hypoxia Cellular Response To Salt Stress Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Potassium Ion Transmembrane Transport Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Metanephric Glomerulus Vasculature Development Ammonium Transmembrane Transport Hydrogen Peroxide Transmembrane Transport Monoatomic Cation Transmembrane Transport
Pathways		Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins Developmental Lineage of Pancreatic Ductal Cells
Drugs		Acetazolamide B-nonylglucoside Mersalyl
Diseases
GWAS		Fractures ( 30598549) Heel bone mineral density ( 28869591 30598549) hemolysis of donated blood (osmotic) ( 34014839) Huntington's disease progression ( 28642124) Kidney stones ( 31729369) Nephrolithiasis ( 22396660) Systolic blood pressure ( 30224653) Total body bone mineral density ( 29304378) Triglyceride levels ( 34074324) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		134 interacting genes: ADAMTSL4 AMOT AQP6 BCL2L13 BEGAIN BLZF1 BMF CCDC136 CCDC57 CCDC85B CCNDBP1 CD79A CDR2 CEP44 CLDN5 COMP CPLX4 CREB3 CRTAC1 CSRNP1 CYSRT1 EFEMP2 EPHB2 ESM1 EVI2B FAM161A FAM209A FNDC9 FOS FSD2 GET1 GJB5 GLI1 GOLGA2 GPR37L1 GPRASP3 GPX8 IFT20 IGFBP6 IHO1 IKZF2 IKZF3 IL21R KCNK5 KCTD17 KCTD9 KHDRBS3 KIAA1958 KLHL26 KRT31 KRT33B KRT37 KRT40 KRTAP1-1 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-4 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE1A LDLRAD1 LDOC1 LIME1 LMNA LPXN LRRC59 MDFI MGST3 MID2 MIF4GD MKRN3 MRM1 MTUS2 MUC1 MYF5 NBPF19 NBPF22P NBPF6 NOTCH2NLA NUTM1 PGPEP1 PICK1 PLA2G10 PLSCR2 PPARA PRDM14 PRDM6 RBAK REL RGS17 RGS20 RIMBP3 RNF122 SAR1A SIAH1 SIVA1 SLC15A2 SLC39A2 SPDYA SPRED1 SPRED2 SPRY2 SPRY3 SPRYD7 SSMEM1 TCF4 TMEM237 TMEM38B TMEM45B TMEM80 TMPRSS2 TNK2 TNS2 TRAF1 TRAF2 TRIM23 TRIM37 TRIM41 TRIM42 TRIM7 TRIP6 TSC1 ZBTB39 ZIM2 ZNF16 ZNF398 ZNF792	114 interacting genes: ADGRA2 AMPD2 AQP1 ARHGAP22 ATP4B C22orf23 CCDC146 CCDC187 CCND1 CDK18 CDKN2A CFAP65 CNNM3 CUL5 DMRT3 DOCK2 FAM110A FAM161A FAM74A4 FH FZD10 GAS2L2 GLIDR GRAP2 GSTK1 HBZ HDAC4 HMGB1 HSPB1 HYCC1 ILF2 IMP3 IRGC LIN37 LNX1 MAP2K2 MOS MRPL15 MRPS9 MTDH NAIF1 NANOS2 NEURL3 NOL7 NSMF NUDCD3 PAXIP1 PEX39 PIAS2 PIMREG PLEKHA7 PMP2 POLDIP3 POLL PRPF31 PSMB10 PTF1A RARA RARB RBP5 RPL28 RPL39L RPL7L1 RPS28 SASH1 SHFL SIRT6 SLC16A13 SPG7 STK25 SYF2 TCEAL1 TEAD4 TFPT THAP10 THAP7 TMEM120B TRAPPC5 TTC23 TYMSOS WNT11 ZBTB24 ZGPAT ZNF124 ZNF136 ZNF155 ZNF169 ZNF20 ZNF223 ZNF230 ZNF334 ZNF394 ZNF417 ZNF439 ZNF440 ZNF480 ZNF490 ZNF552 ZNF555 ZNF557 ZNF564 ZNF578 ZNF581 ZNF627 ZNF670 ZNF696 ZNF697 ZNF707 ZNF785 ZNF786 ZNF835 ZNF837 ZNRF2P1 ZSCAN26
Entrez ID		358	23582
HPRD ID		00140	06156
Ensembl ID		ENSG00000240583	ENSG00000166946
Uniprot IDs		A0A024RA31 P29972	B4DHB5 O95273
PDB IDs		1FQY 1H6I 1IH5 4CSK 6POJ 7UZE 8CT2 8CTE	3AY5
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Protein Binding Identical Protein Binding Negative Regulation Of Lens Fiber Cell Differentiation Hair Cycle Regulation Of Lens Fiber Cell Differentiation Tumor Necrosis Factor Receptor Binding Cellular Developmental Process	Zinc Ion Binding DNA Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Metal Ion Binding Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Heterocyclic Compound Binding Regulation Of Metabolic Process SUMO Transferase Activity
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