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AQP1 and EFEMP2
Number of citations of the paper that reports this interaction (PubMedID
16189514
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
AQP1
EFEMP2
Description
aquaporin 1 (Colton blood group)
EGF-like fibulin extracellular matrix protein 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Plasma Membrane
Brush Border
Basal Plasma Membrane
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Axon
Brush Border Membrane
Nuclear Membrane
Sarcolemma
Apical Part Of Cell
Extracellular Exosome
Ankyrin-1 Complex
Microfibril
Extracellular Region
Basement Membrane
Extracellular Matrix
Extracellular Exosome
Elastic Fiber
Extracellular Vesicle
Molecular Function
Intracellularly CGMP-activated Cation Channel Activity
Potassium Channel Activity
Water Transmembrane Transporter Activity
Protein Binding
Ammonium Channel Activity
Potassium Ion Transmembrane Transporter Activity
Glycerol Transmembrane Transporter Activity
Water Channel Activity
Channel Activity
Transmembrane Transporter Activity
Nitric Oxide Transmembrane Transporter Activity
Carbon Dioxide Transmembrane Transporter Activity
Identical Protein Binding
Ephrin Receptor Binding
Hydrogen Peroxide Channel Activity
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Heparin Binding
Protein Homodimerization Activity
Biological Process
Renal Water Homeostasis
Glomerular Filtration
Renal Water Transport
Potassium Ion Transport
Water Transport
Cell Volume Homeostasis
Hyperosmotic Response
Intracellular Water Homeostasis
Fibroblast Migration
Positive Regulation Of Fibroblast Migration
Carbon Dioxide Transport
Glycerol Transmembrane Transport
Cell Migration
Sensory Perception Of Pain
Cellular Homeostasis
CGMP-mediated Signaling
Lateral Ventricle Development
Pancreatic Juice Secretion
Nitric Oxide Transport
Establishment Or Maintenance Of Actin Cytoskeleton Polarity
Secretion By Cell
Cerebrospinal Fluid Secretion
Secretory Granule Organization
Cellular Response To UV
Transepithelial Water Transport
Carbon Dioxide Transmembrane Transport
Wound Healing
Odontogenesis
Negative Regulation Of Apoptotic Process
Lipid Digestion
Positive Regulation Of Angiogenesis
Positive Regulation Of Saliva Secretion
Positive Regulation Of Fibroblast Proliferation
Camera-type Eye Morphogenesis
Defense Response To Gram-negative Bacterium
Multicellular Organismal-level Water Homeostasis
Corticotropin Secretion
Establishment Of Localization In Cell
Transmembrane Transport
Renal Water Absorption
Cellular Response To Hydrogen Peroxide
Cellular Response To Mechanical Stimulus
Cellular Response To Copper Ion
Cellular Response To Mercury Ion
Cellular Response To Retinoic Acid
Cellular Response To CAMP
Cellular Response To Hypoxia
Cellular Response To Salt Stress
Cellular Hyperosmotic Response
Cellular Response To Dexamethasone Stimulus
Cellular Response To Nitric Oxide
Potassium Ion Transmembrane Transport
Metanephric Descending Thin Limb Development
Metanephric Proximal Straight Tubule Development
Metanephric Proximal Convoluted Tubule Segment 2 Development
Metanephric Glomerulus Vasculature Development
Ammonium Transmembrane Transport
Hydrogen Peroxide Transmembrane Transport
Monoatomic Cation Transmembrane Transport
Aorta Development
Elastic Fiber Assembly
Aorta Smooth Muscle Tissue Morphogenesis
Artery Development
Vascular Associated Smooth Muscle Cell Development
Regulation Of Collagen Fibril Organization
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Aortic Smooth Muscle Cell Differentiation
Positive Regulation Of Smooth Muscle Cell-matrix Adhesion
Pathways
Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Vasopressin regulates renal water homeostasis via Aquaporins
Passive transport by Aquaporins
Developmental Lineage of Pancreatic Ductal Cells
Molecules associated with elastic fibres
Molecules associated with elastic fibres
Drugs
Acetazolamide
B-nonylglucoside
Mersalyl
Diseases
Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS
Fractures (
30598549
)
Heel bone mineral density (
28869591
30598549
)
hemolysis of donated blood (osmotic) (
34014839
)
Huntington's disease progression (
28642124
)
Kidney stones (
31729369
)
Nephrolithiasis (
22396660
)
Systolic blood pressure (
30224653
)
Total body bone mineral density (
29304378
)
Triglyceride levels (
34074324
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Acne (severe) (
24927181
)
Adult body size (
32376654
)
Birth weight (
31043758
)
Body size at age 10 (
32376654
)
Monocyte count (
32888494
)
Retinal detachment or retinal break (
31816047
)
Interacting Genes
134 interacting genes:
ADAMTSL4
AMOT
AQP6
BCL2L13
BEGAIN
BLZF1
BMF
CCDC136
CCDC57
CCDC85B
CCNDBP1
CD79A
CDR2
CEP44
CLDN5
COMP
CPLX4
CREB3
CRTAC1
CSRNP1
CYSRT1
EFEMP2
EPHB2
ESM1
EVI2B
FAM161A
FAM209A
FNDC9
FOS
FSD2
GET1
GJB5
GLI1
GOLGA2
GPR37L1
GPRASP3
GPX8
IFT20
IGFBP6
IHO1
IKZF2
IKZF3
IL21R
KCNK5
KCTD17
KCTD9
KHDRBS3
KIAA1958
KLHL26
KRT31
KRT33B
KRT37
KRT40
KRTAP1-1
KRTAP1-5
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP12-4
KRTAP3-2
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP6-2
KRTAP9-2
KRTAP9-8
LCE1A
LDLRAD1
LDOC1
LIME1
LMNA
LPXN
LRRC59
MDFI
MGST3
MID2
MIF4GD
MKRN3
MRM1
MTUS2
MUC1
MYF5
NBPF19
NBPF22P
NBPF6
NOTCH2NLA
NUTM1
PGPEP1
PICK1
PLA2G10
PLSCR2
PPARA
PRDM14
PRDM6
RBAK
REL
RGS17
RGS20
RIMBP3
RNF122
SAR1A
SIAH1
SIVA1
SLC15A2
SLC39A2
SPDYA
SPRED1
SPRED2
SPRY2
SPRY3
SPRYD7
SSMEM1
TCF4
TMEM237
TMEM38B
TMEM45B
TMEM80
TMPRSS2
TNK2
TNS2
TRAF1
TRAF2
TRIM23
TRIM37
TRIM41
TRIM42
TRIM7
TRIP6
TSC1
ZBTB39
ZIM2
ZNF16
ZNF398
ZNF792
133 interacting genes:
ADAMTSL4
AMMECR1
ANAPC11
AP1M1
APEX2
AQP1
ARRDC3
ATN1
ATXN1
ATXN7
BAG6
C3
C5orf24
CACNA1A
CATSPER1
CCDC33
CCND3
CCNK
CDPF1
CLPP
CNNM3
COL8A1
CREB5
CXCL5
CYSRT1
DGCR6
DOK7
DYRK1A
FAM107A
FAM110A
FAM124B
FAM74A4
FAM90A1
FBXW5
FTO
FXR1
GFI1B
GLRX3
HDAC4
HHEX
HHIPL1
HOXA1
HPCAL1
HSD3B7
HSPA12B
HSPBP1
IGFBP6
IL16
INCA1
ITGB5
KLF1
KRTAP10-8
KRTAP11-1
KRTAP12-2
KRTAP13-3
KRTAP19-5
KRTAP26-1
KRTAP3-2
LBX1
LCE1A
LCE1C
LCE1E
LCE2C
LCE2D
LCE3A
LCE3C
LCE3D
LCE3E
LINGO1
LNX1
MDFI
MEOX2
MRPL12
MXI1
NEDD4L
NOS3
NR1D2
NTM
NUFIP2
OTX1
P2RX7
PIDD1
PITX1
PLSCR1
PLSCR4
PROP1
PRPF31
PRR32
PTGER3
RAB40B
RBAK
RBP3
RBPMS
RERE
RHOXF2
RHPN1
RIBC2
RNF138
SGTA
SGTB
SHANK3
SLC16A5
SLC23A1
SLC25A48
SPACA9
SPATA24
SPATA3
SPATA8
SPRY4
STK16
TCAF1
THAP7
TLE5
TLX3
TP53
TRIB3
TRIM42
UBQLN1
UBQLN4
USP21
ZNF263
ZNF345
ZNF426
ZNF558
ZNF57
ZNF581
ZNF587
ZNF638
ZNF670
ZNF699
ZNF768
ZNF774
ZNF837
Entrez ID
358
30008
HPRD ID
00140
05221
Ensembl ID
ENSG00000240583
ENSG00000172638
Uniprot IDs
A0A024RA31
P29972
O95967
Q9H3D5
PDB IDs
1FQY
1H6I
1IH5
4CSK
6POJ
7UZE
8CT2
8CTE
2KL7
Enriched GO Terms of Interacting Partners
?
Intermediate Filament
Keratin Filament
Protein Binding
Identical Protein Binding
Negative Regulation Of Lens Fiber Cell Differentiation
Hair Cycle
Regulation Of Lens Fiber Cell Differentiation
Tumor Necrosis Factor Receptor Binding
Cellular Developmental Process
Protein Binding
Keratinization
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Epidermis Development
Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Identical Protein Binding
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
DNA Binding
Regulation Of RNA Metabolic Process
CD4 Receptor Binding
Regulation Of Primary Metabolic Process
Tissue Development
Regulation Of Nucleobase-containing Compound Metabolic Process
TRC Complex
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Nucleus
Sequence-specific Double-stranded DNA Binding
Intermediate Filament
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of ERAD Pathway
Zinc Ion Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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