AQP1 and KRTAP4-2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		AQP1	KRTAP4-2
Gene Name		aquaporin 1 (Colton blood group)	keratin associated protein 4-2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Basal Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Symbiont-containing Vacuole Symbiont-containing Vacuole Membrane Brush Border Membrane Nuclear Membrane Sarcolemma Axon Terminus Apical Part Of Cell Extracellular Vesicular Exosome	Keratin Filament
	Molecular Function	Intracellular CGMP Activated Cation Channel Activity Potassium Channel Activity Water Transmembrane Transporter Activity Protein Binding Ammonium Transmembrane Transporter Activity Potassium Ion Transmembrane Transporter Activity Glycerol Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Transmembrane Transporter Activity Nitric Oxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transporter Activity Ephrin Receptor Binding
	Biological Process	Renal Water Homeostasis Glomerular Filtration Renal Water Transport CGMP Biosynthetic Process Potassium Ion Transport Water Transport Cell Volume Homeostasis Cellular Water Homeostasis Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Epithelial Cell Migration Carbon Dioxide Transport Ammonium Transport Bicarbonate Transport Glycerol Transport Sensory Perception Of Pain Cellular Homeostasis Lateral Ventricle Development Pancreatic Juice Secretion Nitric Oxide Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Secretory Granule Organization Cellular Response To Stress Cellular Response To UV Transepithelial Water Transport Carbon Dioxide Transmembrane Transport Wound Healing Odontogenesis Response To Drug Hyperosmotic Salinity Response Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Estrogen Lipid Digestion Small Molecule Metabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Saliva Secretion Positive Regulation Of Fibroblast Proliferation Camera-type Eye Morphogenesis Multicellular Organismal Water Homeostasis Corticotropin Secretion Transmembrane Transport Renal Water Absorption Cellular Response To Hydrogen Peroxide Cellular Response To Inorganic Substance Cellular Response To Mechanical Stimulus Cellular Response To Copper Ion Cellular Response To Mercury Ion Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Hypoxia Cellular Response To Salt Stress Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Potassium Ion Transmembrane Transport Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Metanephric Glomerulus Vasculature Development Ammonium Transmembrane Transport Maintenance Of Symbiont-containing Vacuole By Host Cation Transmembrane Transport
Pathways		O2/CO2 exchange in erythrocytes Erythrocytes take up carbon dioxide and release oxygen Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins Erythrocytes take up oxygen and release carbon dioxide Aquaporin-mediated transport
Drugs		Acetazolamide
Diseases
GWAS		Nephrolithiasis ( 22396660)
Protein-Protein Interactions		42 interactors: ADAMTSL4 CCDC136 CCDC36 CCDC57 CCDC85B CEP44 CRTAC1 CSRNP1 EFEMP2 EPHB2 FOS FSD2 IKZF2 IKZF3 KCTD17 KCTD9 KIAA1958 KRT31 KRT33B KRT40 KRTAP10-3 KRTAP10-7 KRTAP4-12 KRTAP4-2 KRTAP9-2 MDFI MID2 MTUS2 NBPF22P NOTCH2NL PICK1 RGS17 RGS20 RIMBP3 SIAH1 SPRY2 TCF4 TNK2 TRAF1 TRAF2 TRIM23 TRIP6	72 interactors: ADAMTSL4 ALDH3B1 AMOTL2 AQP1 ATG9A BYSL C19orf66 CHIC2 CHRD CRCT1 CREB5 DLGAP2 DOCK2 FAM74A4 GLRX3 GNMT HOXA1 HPCAL1 HSD3B7 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP26-1 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1B LCE2A LCE3C LCE3E LCE4A LNX1 MEOX2 NLK NOTCH2NL NR1D2 NUFIP2 OTX1 PDE9A PGLS PIN1 PLSCR1 POM121L8P PRKAB2 PRKAG1 PSMA6 PVRL3 RASSF5 RGS20 SLC23A1 SLC25A10 SPATA24 SPATA3 SPRY1 TCEANC TINAGL1 TRIM42 TXNDC5 TYRO3 WDYHV1 ZBTB24 ZNF124 ZNF20 ZNF417 ZNF559 ZNF581
Entrez ID		358	85291
HPRD ID		00140	13944
Ensembl ID		ENSG00000240583	ENSG00000244537
Uniprot IDs		B4DPF5 B4E3E3 P29972	Q9BYR5
PDB IDs		1FQY 1H6I 1IH5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Binding Developmental Process Regulation Of Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Dendritic Spine Organization Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Signal Transduction Axonal Fasciculation Embryonic Organ Morphogenesis Regulation Of Signal Transduction Signal Transduction Regulation Of Protein Binding Cell Differentiation Regulation Of Cellular Process Face Morphogenesis Neuron Recognition Regulation Of Apoptotic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Head Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Signaling Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Communication Negative Regulation Of Signaling Face Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleocytoplasmic Transport Cellular Response To Extracellular Stimulus Embryonic Organ Development I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Fat Cell Differentiation Body Morphogenesis DNA Methylation TRIF-dependent Toll-like Receptor Signaling Pathway Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Termination Of Signal Transduction Toll-like Receptor 3 Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway	Keratinization Keratinocyte Differentiation Epidermal Cell Differentiation Epidermis Development Transcription, DNA-templated Epithelium Development Skin Development RNA Biosynthetic Process Organ Development Tissue Development Transepithelial Transport Cellular Process Cellular Nitrogen Compound Metabolic Process Gene Expression Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Multicellular Organismal Development Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Apoptotic Cell Clearance BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Abducens Nerve Formation Maintenance Of Symbiont-containing Vacuole By Host Transepithelial Water Transport Optokinetic Behavior Transepithelial L-ascorbic Acid Transport Organic Anion Transport
Tagcloud ?		2cl absorption acclimation bumetanide circuit cl cotransporter eel exchanger gn governed guanylin hco3 intestine isc mi ncc nccbeta nkcc nkcc2beta nullified player remainder seawater slc26a6 teleost transporters versa vice
Tagcloud (Difference) ?		2cl absorption acclimation bumetanide circuit cl cotransporter eel exchanger gn governed guanylin hco3 intestine isc mi ncc nccbeta nkcc nkcc2beta nullified player remainder seawater slc26a6 teleost transporters versa vice
Tagcloud (Intersection) ?