ACTL6A and SMARCA2

Number of citations of the paper that reports this interaction (PubMedID 31753913)
116

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, biochemical, cross-linking study)
HPRD (in vivo)

		ACTL6A	SMARCA2
Description		actin like 6A	SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2
Image
GO Annotations	Cellular Component	Kinetochore Chromatin Nucleosome Nucleus Nucleoplasm Plasma Membrane Nuclear Matrix SWI/SNF Complex RSC-type Complex Ino80 Complex Protein-containing Complex Brahma Complex NuA4 Histone Acetyltransferase Complex NpBAF Complex GBAF Complex	Chromatin Nucleus Nucleoplasm SWI/SNF Complex Brahma Complex Intermediate Filament Cytoskeleton NpBAF Complex NBAF Complex BBAF Complex GBAF Complex
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Histone Binding Nucleosome Array Spacer Activity
	Biological Process	Telomere Maintenance Blastocyst Formation Neural Retina Development Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Signal Transduction Nervous System Development Positive Regulation Of Cell Population Proliferation Spinal Cord Development Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Regulation Of Apoptotic Process Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development System Development Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Telomere Maintenance In Response To DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatid Development Nervous System Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cell Growth Heterochromatin Formation Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		HATs acetylate histones RMTs methylate histone arginines UCH proteinases DNA Damage Recognition in GG-NER RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases
GWAS		Pars opercularis volume ( 31530798)	Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma (childhood onset) ( 27611488) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Brain morphology (MOSTest) ( 32665545) Lead levels ( 26025379) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Monobrow ( 27182965) Neuritic plaque ( 31497858) Nose size ( 27182965) Parkinson's disease ( 26227905) Superior frontal gyrus grey matter volume ( 25335168) Systolic blood pressure ( 26969751) Thyroid volume in Hashimoto’s thyroiditis ( 32019955)
Interacting Genes		16 interacting genes: ARHGDIA CDK2 CDK9 EWSR1 FLII MRGBP MYC OGT POLR2A PTEN RELA RUVBL1 SMARCA2 SMARCA4 TRRAP UBC	53 interacting genes: ACTL6A ACTL6B ACTN2 ANO10 APC2 AR ARID1B BEND7 BRCA1 CCDC136 CEBPA CEP72 CNTROB CXXC1 DAB2IP DNM2 ESR1 FOXP1 GAPDH GCC1 GFAP H3C1 HSPB1 ITPRID2 KHDRBS1 LAMC1 MDM2 MDM4 MECP2 MPRIP MYB MYC MYO5B NECAB2 NR0B2 NR3C1 NR4A2 NUP62 PHB1 PICK1 PITX1 PPFIA2 PPP1R12C PRPF6 RAP1A SDCBP SIN3B SPAG5 SS18 SUPT4H1 TACC2 TNFAIP1 ZNF821
Entrez ID		86	6595
HPRD ID		05389	02483
Ensembl ID		ENSG00000136518	ENSG00000080503
Uniprot IDs		O96019	B1ALF6 B4DNT1 B4DSC8 F6T8Q0 F6VDE0 P51531 Q56A76 Q8N9Q1
PDB IDs		6LTJ 7VDV 7Y8R 8QR1 8X15 8X19 8X1C 8XVG 8XVT 9C4B 9C57 9C62 9C6N	2DAT 4QY4 5DKC 5DKH 6EG2 6EG3 6HAX 6HAY 6HAZ 7S4E 7Z6L 7Z76 7Z77 7Z78 8G1P 8QJT 9D11 9D12 9E1K 9E30 9E31
Enriched GO Terms of Interacting Partners?		Chromatin Organization Positive Regulation Of DNA Metabolic Process Regulation Of DNA Metabolic Process Nucleoplasm Positive Regulation Of Double-strand Break Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA Repair Positive Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Positive Regulation Of DNA Repair Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Double-strand Break Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Response To Stress Positive Regulation Of Biosynthetic Process Regulation Of Stem Cell Population Maintenance Regulation Of RNA Metabolic Process Nucleus Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process NuA4 Histone Acetyltransferase Complex Regulation Of Transcription By RNA Polymerase II Regulation Of Chromosome Organization Positive Regulation Of Macromolecule Metabolic Process ATP-dependent Activity, Acting On DNA Nucleosome Array Spacer Activity Positive Regulation Of Metabolic Process Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of MiRNA Transcription Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of MiRNA Metabolic Process Regulation Of Gene Expression BBAF Complex DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Positive Regulation Of DNA Recombination Regulation Of Primary Metabolic Process Swr1 Complex Regulation Of Double-strand Break Repair Via Homologous Recombination NpBAF Complex GBAF Complex Regulation Of MiRNA Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Component Organization Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Developmental Process Negative Regulation Of Biosynthetic Process Protein-containing Complex Positive Regulation Of Cell Population Proliferation Organelle Organization Chromatin Identical Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Regulation Of Cell Population Proliferation SWI/SNF Complex Regulation Of MiRNA Transcription Chromatin Remodeling Regulation Of Developmental Process Estrogen Response Element Binding Regulation Of G0 To G1 Transition Cytoskeleton Protein Domain Specific Binding Microtubule Organizing Center Organization Regulation Of MiRNA Metabolic Process Nucleoplasm Brahma Complex NpBAF Complex GBAF Complex
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