SMARCA2 and ARID1B

Number of citations of the paper that reports this interaction (PMID 12200431)
32

Data Source:
HPRD (in vivo, in vitro)

		SMARCA2	ARID1B
Gene Name		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	AT rich interactive domain 1B (SWI1-like)
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm SWI/SNF Complex Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton NpBAF Complex NBAF Complex	Nucleoplasm Cytoplasm SWI/SNF Complex NBAF Complex
	Molecular Function	RNA Polymerase II Transcription Coactivator Activity Transcription Coactivator Activity Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Histone Binding Transcription Regulatory Region DNA Binding	DNA Binding Transcription Coactivator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Growth Aortic Smooth Muscle Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Transcription, DNA-templated Nervous System Development Chromatin-mediated Maintenance Of Transcription
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)	Alzheimer's disease biomarkers ( 23419831) Pancreatic cancer ( 22158540) Uric acid levels ( 21294900)
Protein-Protein Interactions		26 interactors: ACTL6A ACTL6B AR ARID1B BEND7 BRCA1 CEBPA DPF3 ESR1 HIST1H3A KHDRBS1 MDM2 MDM4 MECP2 MYB MYC NR0B2 NR3C1 NR4A2 PHB PITX1 PRMT5 PRPF6 SDCBP SIN3B SS18	5 interactors: CUL2 HIST2H2BE SMAD9 SMARCA2 SMARCA4
Entrez ID		6595	57492
HPRD ID		02483	10660
Ensembl ID		ENSG00000080503	ENSG00000049618
Uniprot IDs		P51531 Q56A76 Q8N9Q1	Q8NFD5
PDB IDs		2DAT	2CXY 2EH9
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Chromatin Organization RNA Metabolic Process Chromatin Modification Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Chromosome Organization Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Organelle Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Cyclic Compound Intracellular Steroid Hormone Receptor Signaling Pathway Response To Steroid Hormone Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter Chromatin Remodeling Developmental Process Negative Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Cellular Process Steroid Hormone Mediated Signaling Pathway Anatomical Structure Development	Aortic Smooth Muscle Cell Differentiation Vascular Smooth Muscle Cell Differentiation Smooth Muscle Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Nucleosome Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Chromatin Assembly Or Disassembly Negative Regulation Of Cell Growth Hindbrain Development Chromatin Remodeling Chromosome Organization DNA Methylation On Cytosine Within A CG Sequence Negative Regulation Of Growth Definitive Erythrocyte Differentiation Response To Hypoxia Glial Cell Fate Determination Methylation-dependent Chromatin Silencing Mullerian Duct Regression Positive Regulation Of Transcription, DNA-templated Muscle Cell Differentiation Regulation Of Cell Growth Positive Regulation By Host Of Viral Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression DNA Methylation On Cytosine Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Androgen Receptor Signaling Pathway Nucleosome Disassembly Blastocyst Hatching Negative Regulation Of Cell Cycle Heart Trabecula Formation Innate Immune Response In Mucosa Anatomical Structure Regression Lens Fiber Cell Development Muscle Structure Development Regulation Of Androgen Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Glial Cell Fate Commitment Regulation Of Nucleic Acid-templated Transcription Vasculature Development Regulation Of RNA Biosynthetic Process Definitive Hemopoiesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of RNA Metabolic Process Antibacterial Humoral Response Heart Trabecula Morphogenesis Antimicrobial Humoral Response Chromatin Modification Blastocyst Growth
Tagcloud ?		abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating	arid2 baf bcl11a bcl11b brd9 calu catalogue constructs cosmic deposited driver establishment existed hairpin knocked mswi mutated ones pearson psuper ranking reporters shrna slippage smarca4 snf sublines swi typing
Tagcloud (Difference) ?		abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense subunits trisomy truncating	arid2 baf bcl11a bcl11b brd9 calu catalogue constructs cosmic deposited driver establishment existed hairpin knocked mswi mutated ones pearson psuper ranking reporters shrna slippage sublines typing
Tagcloud (Intersection) ?		smarca4 snf swi