SMARCA2 and ARID1B

Number of citations of the paper that reports this interaction (PubMedID 12200431)
0

Data Source:
HPRD (in vitro, in vivo)

		SMARCA2	ARID1B
Description		SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2	AT-rich interaction domain 1B
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm SWI/SNF Complex Brahma Complex Intermediate Filament Cytoskeleton NpBAF Complex NBAF Complex BBAF Complex GBAF Complex	Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane SWI/SNF Complex Brahma Complex NpBAF Complex NBAF Complex BBAF Complex
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Histone Binding Nucleosome Array Spacer Activity	DNA Binding Transcription Coactivator Activity Protein Binding Nucleosome Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatid Development Nervous System Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cell Growth Heterochromatin Formation Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma (childhood onset) ( 27611488) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Brain morphology (MOSTest) ( 32665545) Lead levels ( 26025379) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Monobrow ( 27182965) Neuritic plaque ( 31497858) Nose size ( 27182965) Parkinson's disease ( 26227905) Superior frontal gyrus grey matter volume ( 25335168) Systolic blood pressure ( 26969751) Thyroid volume in Hashimoto’s thyroiditis ( 32019955)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer's disease biomarkers ( 23419831) Calcium levels ( 24068962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Iris color (b* coordinate) ( 30895295) Lipoprotein (a) levels ( 26377243) Low density lipoprotein cholesterol levels ( 30498476) Multiple system atrophy (pathologically confirmed) ( 27629089) Pancreatic cancer ( 22158540) Psychosis proneness (perceptual aberration scale and revised physical anhedonia scale) ( 28525603) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Type 2 diabetes ( 29621232) Vein graft stenosis in coronary artery bypass grafting ( 25881214) Western dietary pattern ( 28644415)
Interacting Genes		53 interacting genes: ACTL6A ACTL6B ACTN2 ANO10 APC2 AR ARID1B BEND7 BRCA1 CCDC136 CEBPA CEP72 CNTROB CXXC1 DAB2IP DNM2 ESR1 FOXP1 GAPDH GCC1 GFAP H3C1 HSPB1 ITPRID2 KHDRBS1 LAMC1 MDM2 MDM4 MECP2 MPRIP MYB MYC MYO5B NECAB2 NR0B2 NR3C1 NR4A2 NUP62 PHB1 PICK1 PITX1 PPFIA2 PPP1R12C PRPF6 RAP1A SDCBP SIN3B SPAG5 SS18 SUPT4H1 TACC2 TNFAIP1 ZNF821	7 interacting genes: CUL2 ENO1 H2BC21 PYGM SMAD9 SMARCA2 SMARCA4
Entrez ID		6595	57492
HPRD ID		02483	10660
Ensembl ID		ENSG00000080503	ENSG00000049618
Uniprot IDs		B1ALF6 B4DNT1 B4DSC8 F6T8Q0 F6VDE0 P51531 Q56A76 Q8N9Q1	A0A1B0GTJ8 A0A1B0GVK1 A0A3F2YNW7 A0A6Q8NVI4 H0Y7H8 Q8NFD5
PDB IDs		2DAT 4QY4 5DKC 5DKH 6EG2 6EG3 6HAX 6HAY 6HAZ 7S4E 7Z6L 7Z76 7Z77 7Z78 8G1P 8QJT 9D11 9D12 9E1K 9E30 9E31	2CXY 2EH9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Component Organization Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Developmental Process Negative Regulation Of Biosynthetic Process Protein-containing Complex Positive Regulation Of Cell Population Proliferation Organelle Organization Chromatin Identical Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Regulation Of Cell Population Proliferation SWI/SNF Complex Regulation Of MiRNA Transcription Chromatin Remodeling Regulation Of Developmental Process Estrogen Response Element Binding Regulation Of G0 To G1 Transition Cytoskeleton Protein Domain Specific Binding Microtubule Organizing Center Organization Regulation Of MiRNA Metabolic Process Nucleoplasm Brahma Complex NpBAF Complex GBAF Complex	Nucleosome Array Spacer Activity BBAF Complex NpBAF Complex GBAF Complex NBAF Complex Regulation Of Nucleotide-excision Repair SWI/SNF Complex ATP-dependent Activity, Acting On DNA Negative Regulation Of Cell Growth Regulation Of G0 To G1 Transition Negative Regulation Of Growth Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Myoblast Differentiation Protein Carboxyl O-methyltransferase Activity Protein-glutamate O-methyltransferase Activity Fructose 6-phosphate Aldolase Activity Regulation Of Stem Cell Population Maintenance Transcription Coactivator Activity Cohesin Loader Activity Scc2-Scc4 Cohesin Loading Complex SMC Loading Complex 10-formyltetrahydrofolate Biosynthetic Process Formate-tetrahydrofolate Ligase Activity Fructose-1-phosphatase Activity Regulation Of Myoblast Differentiation Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Nucleoplasm Glycogen Phosphorylase Activity Positive Regulation Of Glucose Mediated Signaling Pathway Formate Biosynthetic Process
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