SMARCA2 and MDM4

Number of citations of the paper that reports this interaction (PMID 25384516)
0

Data Source:
BioGRID (pull down)

		SMARCA2	MDM4
Gene Name		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	MDM4, p53 regulator
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Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm SWI/SNF Complex Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton NpBAF Complex NBAF Complex	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Transcription Coactivator Activity Transcription Coactivator Activity Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Histone Binding Transcription Regulatory Region DNA Binding	Protein Binding Zinc Ion Binding Enzyme Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Growth Aortic Smooth Muscle Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process G0 To G1 Transition Protein Stabilization Negative Regulation Of Cell Cycle Arrest Cellular Response To Hypoxia
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)	Breast cancer ( 23535733) Breast Cancer in BRCA1 mutation carriers ( 23544013) Cognitive performance ( 19734545) Prostate cancer ( 23535732)
Protein-Protein Interactions		26 interactors: ACTL6A ACTL6B AR ARID1B BEND7 BRCA1 CEBPA DPF3 ESR1 HIST1H3A KHDRBS1 MDM2 MDM4 MECP2 MYB MYC NR0B2 NR3C1 NR4A2 PHB PITX1 PRMT5 PRPF6 SDCBP SIN3B SS18	42 interactors: AKT1 APP ARF1 ATM CAPN7 CASP3 CD160 CDK1 CHEK1 CHEK2 CSNK1A1 E2F1 EP300 LRSAM1 MDM2 MKRN3 MNAT1 PRKAA1 RAD54B RB1 RN5S1@ RNF115 SFN SMAD3 SMAD4 SMARCA2 TP53 TP63 TP73 TRIM46 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 USP7 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		6595	4194
HPRD ID		02483	04082
Ensembl ID		ENSG00000080503	ENSG00000198625
Uniprot IDs		P51531 Q56A76 Q8N9Q1	O15151 Q59FS6 Q68DC0
PDB IDs		2DAT	2CR8 2VJE 2VJF 2VYR 3DAB 3EQY 3FDO 3FE7 3FEA 3JZO 3JZP 3JZQ 3LBJ 3U15
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Chromatin Organization RNA Metabolic Process Chromatin Modification Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Chromosome Organization Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Organelle Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Cyclic Compound Intracellular Steroid Hormone Receptor Signaling Pathway Response To Steroid Hormone Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter Chromatin Remodeling Developmental Process Negative Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Cellular Process Steroid Hormone Mediated Signaling Pathway Anatomical Structure Development	Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Death Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Response To Abiotic Stimulus Cellular Response To Stress Cell Cycle Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Hypoxia Intracellular Signal Transduction Cellular Response To Decreased Oxygen Levels Response To Hypoxia Positive Regulation Of Cell Death Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Cellular Response To Oxygen Levels Response To Stress Regulation Of Cell Death Cellular Response To Stimulus Regulation Of Intracellular Transport Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction DNA Damage Checkpoint Regulation Of Cellular Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Signal Transduction Regulation Of Cellular Component Organization Mitotic Cell Cycle Phase Transition Regulation Of Signal Transduction
Tagcloud ?		abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating	aberrations abstract along attractive cdk cdk4 checkpoint correlate cyclind developments entered highlights kinases logical make maximizing mdm2 melanoma melanomagenesis p16 preliminary rb rb1 reactivating reactivation reporting summary targeting video
Tagcloud (Difference) ?		abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating	aberrations abstract along attractive cdk cdk4 checkpoint correlate cyclind developments entered highlights kinases logical make maximizing mdm2 melanoma melanomagenesis p16 preliminary rb rb1 reactivating reactivation reporting summary targeting video
Tagcloud (Intersection) ?