ACTL6A and FLII

Number of citations: 72 (PubMedID 14966289)
Data Source: HPRD (in vivo)

		ACTL6A	FLII
Name		actin like 6A	FLII actin remodeling protein
Structure			No pdb structure
GO Annotations	Cellular Component	Kinetochore Chromatin Nucleosome Nucleus Nucleoplasm Plasma Membrane Nuclear Matrix SWI/SNF Complex RSC-type Complex Ino80 Complex Protein-containing Complex Brahma Complex NuA4 Histone Acetyltransferase Complex NpBAF Complex GBAF Complex	Podosome Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Brush Border Focal Adhesion Actin Cytoskeleton Centriolar Satellite Cell Projection Anchoring Junction
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding	Actin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding
	Biological Process	Telomere Maintenance Blastocyst Formation Neural Retina Development Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Signal Transduction Nervous System Development Positive Regulation Of Cell Population Proliferation Spinal Cord Development Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Regulation Of Apoptotic Process Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development System Development Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Telomere Maintenance In Response To DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Actin Polymerization Or Depolymerization Myofibril Assembly Sarcomere Organization Actin Filament Severing Barbed-end Actin Filament Capping
Pathways		HATs acetylate histones RMTs methylate histone arginines UCH proteinases DNA Damage Recognition in GG-NER RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	None
GWAS		Pars opercularis volume ( 31530798 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: ERO1B	1 novel interactors: MAPK7
Interacting Genes		16 interacting genes: ARHGDIA CDK2 CDK9 EWSR1 FLII MRGBP MYC OGT POLR2A PTEN RELA RUVBL1 SMARCA2 SMARCA4 TRRAP UBC	15 interacting genes: ACTB ACTL6A CARM1 DLST ESR1 GRIP1 LCOR LRRFIP1 LRRFIP2 MYD88 NCOA2 OPTN PRMT1 RNF34 TRAIP
Entrez ID		86	2314
HPRD ID		05389	02647
Ensembl ID		ENSG00000136518	ENSG00000177731
Uniprot IDs		O96019	Q13045
PDB IDs		6LTJ 7VDV 7Y8R 8QR1 8X15 8X19 8X1C 8XVG 8XVT 9C4B 9C57 9C62 9C6N	Not available
GO Terms Enriched among Interactors		Chromatin Organization Positive Regulation Of DNA Metabolic Process Regulation Of DNA Metabolic Process Nucleoplasm Positive Regulation Of Double-strand Break Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA Repair Positive Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Positive Regulation Of DNA Repair Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Double-strand Break Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Response To Stress Positive Regulation Of Biosynthetic Process Regulation Of Stem Cell Population Maintenance Regulation Of RNA Metabolic Process Nucleus Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process NuA4 Histone Acetyltransferase Complex Regulation Of Transcription By RNA Polymerase II Regulation Of Chromosome Organization Positive Regulation Of Macromolecule Metabolic Process ATP-dependent Activity, Acting On DNA Nucleosome Array Spacer Activity Positive Regulation Of Metabolic Process Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of MiRNA Transcription Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of MiRNA Metabolic Process Regulation Of Gene Expression BBAF Complex DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Positive Regulation Of DNA Recombination Regulation Of Primary Metabolic Process Swr1 Complex Regulation Of Double-strand Break Repair Via Homologous Recombination NpBAF Complex GBAF Complex Regulation Of MiRNA Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of DNA-templated Transcription Nucleoplasm Nitric-oxide Synthase Regulator Activity Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Chromatin Remodeling Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Regulation Of RNA Metabolic Process Positive Regulation Of DNA Recombination Nucleus Intracellular Receptor Signaling Pathway Protein Methyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Brahma Complex Regulation Of Macromolecule Metabolic Process NpBAF Complex Regulation Of Double-strand Break Repair Via Homologous Recombination GBAF Complex Chromatin Organization RSC-type Complex Cellular Response To Oxygen-containing Compound Positive Regulation Of Double-strand Break Repair Regulation Of Gene Expression Positive Regulation Of Cell Population Proliferation Beta-catenin Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of DNA Recombination Positive Regulation Of DNA Repair Signal Transduction NuA4 Histone Acetyltransferase Complex Regulation Of Nucleotide-excision Repair Regulation Of Double-strand Break Repair SWI/SNF Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Methyltransferase Activity Protein-containing Complex Cellular Response To Estradiol Stimulus Negative Regulation Of Intracellular Signal Transduction Regulation Of G0 To G1 Transition Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Signal Transduction Nucleosomal DNA Binding