SMARCA2 and ACTL6B

Number of citations of the paper that reports this interaction (PMID 12437990)
5

Data Source:
HPRD (in vitro, in vivo)

		SMARCA2	ACTL6B
Gene Name		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	actin-like 6B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm SWI/SNF Complex Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton NpBAF Complex NBAF Complex	Nucleus Nucleolus SWI/SNF Complex NBAF Complex
	Molecular Function	RNA Polymerase II Transcription Coactivator Activity Transcription Coactivator Activity Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Histone Binding Transcription Regulatory Region DNA Binding	Transcription Coactivator Activity Structural Constituent Of Cytoskeleton
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Growth Aortic Smooth Muscle Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)	Red blood cell traits ( 23222517)
Protein-Protein Interactions		26 interactors: ACTL6A ACTL6B AR ARID1B BEND7 BRCA1 CEBPA DPF3 ESR1 HIST1H3A KHDRBS1 MDM2 MDM4 MECP2 MYB MYC NR0B2 NR3C1 NR4A2 PHB PITX1 PRMT5 PRPF6 SDCBP SIN3B SS18	11 interactors: ANXA7 APP CDKN1A COQ9 CSNK2B CTBP1 GSK3B PLK1 SMARCA2 SMN1 TK1
Entrez ID		6595	51412
HPRD ID		02483	12419
Ensembl ID		ENSG00000080503	ENSG00000077080
Uniprot IDs		P51531 Q56A76 Q8N9Q1	O94805
PDB IDs		2DAT
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Chromatin Organization RNA Metabolic Process Chromatin Modification Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Chromosome Organization Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Organelle Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Cyclic Compound Intracellular Steroid Hormone Receptor Signaling Pathway Response To Steroid Hormone Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter Chromatin Remodeling Developmental Process Negative Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Cellular Process Steroid Hormone Mediated Signaling Pathway Anatomical Structure Development	Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Binding Phosphate-containing Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Modification Process Regulation Of Protein Binding Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Ketone Metabolic Process Response To Toxic Substance Developmental Process Regulation Of Protein Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Metabolic Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Growth Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Kinase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Anatomical Structure Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Negative Regulation Of Catalytic Activity Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Phosphorylation Response To Metal Ion Cellular Response To Heat Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Difference) ?		abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Intersection) ?