ACTL6A and ARHGDIA

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		ACTL6A	ARHGDIA
Name		actin like 6A	Rho GDP dissociation inhibitor alpha
Structure
GO Annotations	Cellular Component	Kinetochore Chromatin Nucleosome Nucleus Nucleoplasm Plasma Membrane Nuclear Matrix SWI/SNF Complex RSC-type Complex Ino80 Complex Protein-containing Complex Brahma Complex NuA4 Histone Acetyltransferase Complex NpBAF Complex GBAF Complex	Immunological Synapse Nucleus Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome Schaffer Collateral - CA1 Synapse
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding
	Biological Process	Telomere Maintenance Blastocyst Formation Neural Retina Development Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Signal Transduction Nervous System Development Positive Regulation Of Cell Population Proliferation Spinal Cord Development Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Regulation Of Apoptotic Process Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development System Development Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Telomere Maintenance In Response To DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Rho Protein Signal Transduction Regulation Of Protein Localization Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Semaphorin-plexin Signaling Pathway Regulation Of Synaptic Vesicle Cycle
Pathways		HATs acetylate histones RMTs methylate histone arginines UCH proteinases DNA Damage Recognition in GG-NER RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Axonal growth inhibition (RHOA activation) Axonal growth stimulation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOH GTPase cycle RHOG GTPase cycle
GWAS		Pars opercularis volume ( 31530798 )	No GWAS studies recorded
Interacting Genes		16 interacting genes: ARHGDIA CDK2 CDK9 EWSR1 FLII MRGBP MYC OGT POLR2A PTEN RELA RUVBL1 SMARCA2 SMARCA4 TRRAP UBC	41 interacting genes: ACTL6A ADRB2 ATXN3 BAK1 CASP3 CASP7 CBX5 CDC42 CDKN1B CEBPA EP300 FEN1 HAAO HDAC6 HERPUD1 IKBKG JUP KAT2B MAPK6 NEDD4L POT1 RAC1 RAC2 RDX RHOA RHOG RHOH SDHC SH3GL3 SIRT2 ST3GAL4 SUMO4 TERF1 TINF2 TRIM13 TWF2 UBE2I UBE2L6 UBE2R2 UFM1 VAV1
Entrez ID		86	396
HPRD ID		05389	03565
Ensembl ID		ENSG00000136518	ENSG00000141522
Uniprot IDs		O96019	J3QQX2 P52565 V9HWE8
PDB IDs		6LTJ 7VDV 7Y8R 8QR1 8X15 8X19 8X1C 8XVG 8XVT 9C4B 9C57 9C62 9C6N	1CC0 1FSO 1FST 1FT0 1FT3 1HH4 1KMT 1QVY 1RHO 2BXW 2JHS 2JHT 2JHU 2JHV 2JHW 2JHX 2JHY 2JHZ 2JI0 2N80 8X8T
GO Terms Enriched among Interactors		Chromatin Organization Positive Regulation Of DNA Metabolic Process Regulation Of DNA Metabolic Process Nucleoplasm Positive Regulation Of Double-strand Break Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA Repair Positive Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Positive Regulation Of DNA Repair Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Double-strand Break Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Response To Stress Positive Regulation Of Biosynthetic Process Regulation Of Stem Cell Population Maintenance Regulation Of RNA Metabolic Process Nucleus Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process NuA4 Histone Acetyltransferase Complex Regulation Of Transcription By RNA Polymerase II Regulation Of Chromosome Organization Positive Regulation Of Macromolecule Metabolic Process ATP-dependent Activity, Acting On DNA Nucleosome Array Spacer Activity Positive Regulation Of Metabolic Process Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of MiRNA Transcription Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of MiRNA Metabolic Process Regulation Of Gene Expression BBAF Complex DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Positive Regulation Of DNA Recombination Regulation Of Primary Metabolic Process Swr1 Complex Regulation Of Double-strand Break Repair Via Homologous Recombination NpBAF Complex GBAF Complex Regulation Of MiRNA Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of Cellular Component Organization Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Catabolic Process Negative Regulation Of Cellular Component Organization Cellular Response To Stress Erythrocyte Enucleation Regulation Of Primary Metabolic Process Actin Filament Organization Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Shelterin Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cytoskeleton Organization Post-translational Protein Modification Response To Stress Positive Regulation Of Metabolic Process Protein Modification Process Macromolecule Catabolic Process Positive Regulation Of Lamellipodium Assembly Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Developmental Process Negative Regulation Of Protein-containing Complex Assembly Protein Kinase Binding Nuclear Telomere Cap Complex Positive Regulation Of Developmental Process Positive Regulation Of Lamellipodium Organization Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Lamellipodium Assembly Fibroblast Apoptotic Process Positive Regulation Of Cell Adhesion Regulation Of Macromolecule Biosynthetic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Actin Filament-based Process Telomere Capping Regulation Of Metabolic Process Small GTPase-mediated Signal Transduction Regulation Of Cell Projection Organization Proteolysis Involved In Protein Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Intracellular Signaling Cassette