ACTL6A and TRRAP

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (biochemical, affinity chromatography technology, biochemical)
HPRD (in vivo)

		ACTL6A	TRRAP
Gene Name		actin-like 6A	transformation/transcription domain-associated protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Plasma Membrane SWI/SNF Complex Ino80 Complex NuA4 Histone Acetyltransferase Complex Protein Complex NpBAF Complex	PCAF Complex Swr1 Complex Nucleus Nucleoplasm Golgi Apparatus STAGA Complex Transcription Factor TFTC Complex NuA4 Histone Acetyltransferase Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding	Transcription Cofactor Activity Transcription Coactivator Activity Protein Binding Kinase Activity Phosphotransferase Activity, Alcohol Group As Acceptor
	Biological Process	Neural Retina Development DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Nervous System Development Regulation Of Growth ATP-dependent Chromatin Remodeling Histone H4 Acetylation Histone H2A Acetylation	DNA Repair Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Checkpoint Phosphorylation Histone Acetylation Histone Deubiquitination Histone H4 Acetylation Histone H2A Acetylation
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones RMTs methylate histone arginines	Chromatin modifying enzymes Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ARHGDIA CDK2 CDK9 EWSR1 FLII MRGBP MYC POLR2A RELA RUVBL1 SMARCA2 SMARCA4 TRRAP	16 interactors: ACTL6A ATXN7 BRCA1 BRD8 CTNNB1 E2F1 E2F4 EP400 ESR1 KAT2A MAX MRGBP MYC PYGO2 SKP1 TCF3
Entrez ID		86	8295
HPRD ID		05389	04310
Ensembl ID		ENSG00000136518	ENSG00000196367
Uniprot IDs		O96019	Q9Y4A5
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Chromatin Organization Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Aortic Smooth Muscle Cell Differentiation Regulation Of Metabolic Process Chromosome Organization Positive Regulation Of Viral Transcription Chromatin Remodeling Negative Regulation Of Cell Cycle Cellular Response To DNA Damage Stimulus Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Gene Expression Regulation Of Viral Transcription Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Viral Process DNA Metabolic Process DNA Repair Histone H2A Acetylation Histone Acetylation Vascular Smooth Muscle Cell Differentiation Internal Peptidyl-lysine Acetylation Positive Regulation Of Transcription, DNA-templated Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Histone Modification Protein Acetylation Organelle Organization Regulation Of Viral Process Regulation Of Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process	Chromatin Modification Chromatin Organization Organelle Organization Chromosome Organization Histone H4 Acetylation Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Histone Acetylation Macromolecule Biosynthetic Process Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone H2A Acetylation Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Histone H3-K4 Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Canonical Wnt Signaling Pathway Regulation Of Fibroblast Proliferation Cellular Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cell Proliferation Organ Development Cellular Response To Indole-3-methanol Regulation Of Histone Methylation Tissue Development Chromatin Remodeling Regulation Of Chromosome Organization
Tagcloud ?			arid1a ash1l atlas broadly chd6 colorectal concordant copy ep300 ep400 exome gains hypermutation mismatch mll2 mll3 nonhypermutated prdm2 preexisting profiled proofreading resembled seq signatures silico srcap tgfbeta uncertain validating
Tagcloud (Difference) ?			arid1a ash1l atlas broadly chd6 colorectal concordant copy ep300 ep400 exome gains hypermutation mismatch mll2 mll3 nonhypermutated prdm2 preexisting profiled proofreading resembled seq signatures silico srcap tgfbeta uncertain validating
Tagcloud (Intersection) ?