SMARCA2 and TACC2

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		SMARCA2	TACC2
Description		SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2	transforming acidic coiled-coil containing protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm SWI/SNF Complex Brahma Complex Intermediate Filament Cytoskeleton NpBAF Complex NBAF Complex BBAF Complex GBAF Complex	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Histone Binding Nucleosome Array Spacer Activity	Nuclear Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatid Development Nervous System Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cell Growth Heterochromatin Formation Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Nuclear Migration Cerebral Cortex Development
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma (childhood onset) ( 27611488) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Brain morphology (MOSTest) ( 32665545) Lead levels ( 26025379) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Monobrow ( 27182965) Neuritic plaque ( 31497858) Nose size ( 27182965) Parkinson's disease ( 26227905) Superior frontal gyrus grey matter volume ( 25335168) Systolic blood pressure ( 26969751) Thyroid volume in Hashimoto’s thyroiditis ( 32019955)	Chronic lymphocytic leukemia (time to first treatment) ( 33510140) Hepcidin/ferritin ratio ( 27846281) Metabolite risk score for predicting weight gain ( 31560688) Myopia (pathological) ( 23049088) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Obesity-related traits ( 23251661) Opioid dependence ( 31250797) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Total body bone mineral density ( 29304378)
Interacting Genes		53 interacting genes: ACTL6A ACTL6B ACTN2 ANO10 APC2 AR ARID1B BEND7 BRCA1 CCDC136 CEBPA CEP72 CNTROB CXXC1 DAB2IP DNM2 ESR1 FOXP1 GAPDH GCC1 GFAP H3C1 HSPB1 ITPRID2 KHDRBS1 LAMC1 MDM2 MDM4 MECP2 MPRIP MYB MYC MYO5B NECAB2 NR0B2 NR3C1 NR4A2 NUP62 PHB1 PICK1 PITX1 PPFIA2 PPP1R12C PRPF6 RAP1A SDCBP SIN3B SPAG5 SS18 SUPT4H1 TACC2 TNFAIP1 ZNF821	18 interacting genes: AURKC BORCS6 CLK2 CLVS2 CREBBP EP300 FMR1 FXR1 GRAMD4 HMG20B KAT2A KAT2B PPP1CC RXRB SMARCA2 SMARCB1 TGM1 YEATS4
Entrez ID		6595	10579
HPRD ID		02483	05600
Ensembl ID		ENSG00000080503	ENSG00000138162
Uniprot IDs		B1ALF6 B4DNT1 B4DSC8 F6T8Q0 F6VDE0 P51531 Q56A76 Q8N9Q1	B2RWP4 B7ZMJ9 D6RAA5 E7EMZ9 E9PBC6 O95359 Q4VXL4 Q4VXL8
PDB IDs		2DAT 4QY4 5DKC 5DKH 6EG2 6EG3 6HAX 6HAY 6HAZ 7S4E 7Z6L 7Z76 7Z77 7Z78 8G1P 8QJT 9D11 9D12 9E1K 9E30 9E31
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Component Organization Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Developmental Process Negative Regulation Of Biosynthetic Process Protein-containing Complex Positive Regulation Of Cell Population Proliferation Organelle Organization Chromatin Identical Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Regulation Of Cell Population Proliferation SWI/SNF Complex Regulation Of MiRNA Transcription Chromatin Remodeling Regulation Of Developmental Process Estrogen Response Element Binding Regulation Of G0 To G1 Transition Cytoskeleton Protein Domain Specific Binding Microtubule Organizing Center Organization Regulation Of MiRNA Metabolic Process Nucleoplasm Brahma Complex NpBAF Complex GBAF Complex	Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Acetyltransferase Activity Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Histone Acetyltransferase Activity Protein Acetylation Chromatin Organization Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Regulation Of DNA Repair Internal Protein Amino Acid Acetylation N-terminal Protein Amino Acid Acetylation Regulation Of Gluconeogenesis Transcription Coactivator Activity Acyltransferase Activity Regulation Of Cellular Response To Stress Negative Regulation Of Gluconeogenesis Histone H3K27 Acetyltransferase Activity Histone H3K9 Acetyltransferase Activity Positive Regulation Of Cell Differentiation Regulation Of Glucose Metabolic Process Positive Regulation Of Double-strand Break Repair Chromatin Remodeling Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Developmental Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Cell Development Regulation Of Multicellular Organismal Development Negative Regulation Of Small Molecule Metabolic Process Chromatin Binding Regulation Of DNA Metabolic Process RNA Strand Annealing Activity Positive Regulation Of DNA Repair Regulation Of Cell Development Protein Modification Process Regulation Of Double-strand Break Repair L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Nervous System Development Transcription Initiation-coupled Chromatin Remodeling Intracellular Membraneless Organelle Negative Regulation Of Centriole Replication Gluconeogenesis Kinetochore Positive Regulation Of Gene Expression, Epigenetic Hexose Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Regulation Of RNA Splicing
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?