EXOSC3 and EXOSC9

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (two hybrid)

		EXOSC3	EXOSC9
Description		exosome component 3	exosome component 9
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Extracellular Exosome Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process DNA Metabolic Process RRNA Processing RNA Processing RNA Catabolic Process MRNA Catabolic Process Gene Expression Regulation Of Gene Expression U4 SnRNA 3'-end Processing DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Poly(A)-dependent SnoRNA 3'-end Processing	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process MRNA Catabolic Process Immune Response RRNA Catabolic Process Positive Regulation Of Cell Growth U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Positive Regulation Of Transcription By RNA Polymerase II Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS			Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 32888494)
Interacting Genes		9 interacting genes: APP ATP5F1D CDK5RAP1 EXOSC4 EXOSC5 EXOSC9 KHSRP MPHOSPH6 TSR2	21 interacting genes: CHMP4B CSNK2A1 DDX39A DDX39B DIS3 ERG EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 HBS1L MTREX PALS2 SETX SUMO2 UBE2I ZDHHC17
Entrez ID		51010	5393
HPRD ID		16220	07315
Ensembl ID		ENSG00000107371	ENSG00000123737
Uniprot IDs		Q9NQT5	B4DXG8 Q06265
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P	2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Exoribonuclease Complex U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process RRNA Processing RNA Processing RRNA Metabolic Process SnRNA 3'-end Processing MRNA 3'-UTR AU-rich Region Binding 3'-5'-RNA Exonuclease Activity SnRNA Processing Nuclear RNA Surveillance RNA Surveillance SnRNA Metabolic Process RNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RNA 3'-end Processing Nucleobase-containing Compound Metabolic Process DNA Deamination Negative Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process Sno(s)RNA Metabolic Process MRNA Catabolic Process Nucleic Acid Metabolic Process Maturation Of 5.8S RRNA DNA Modification RNA Binding Nucleolus Response To Copper Ion RNA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Response To Other Organism MRNA Metabolic Process Negative Regulation Of Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Sebum Secreting Cell Proliferation Positive Regulation Of Translational Fidelity TRNA-2-methylthio-N(6)-dimethylallyladenosine(37) Synthase Activity Euchromatin Regulation Of Nitric Oxide Biosynthetic Process	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity U4 SnRNA 3'-end Processing RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Nuclear RNA Surveillance RNA Surveillance MRNA Catabolic Process SnRNA 3'-end Processing Nuclear MRNA Surveillance SnRNA Metabolic Process Nucleobase-containing Compound Catabolic Process SnRNA Processing RRNA Catabolic Process MRNA Metabolic Process RRNA Processing RRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Macromolecule Catabolic Process 3'-5'-RNA Exonuclease Activity RNA Metabolic Process RNA Processing RNA Binding RNA 3'-end Processing Sno(s)RNA Metabolic Process Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Macromolecule Metabolic Process Nucleic Acid Metabolic Process RRNA 3'-end Processing TRNA Decay DNA Deamination Catabolic Process Nucleolus Nucleobase-containing Compound Metabolic Process CUT Catabolic Process Nucleoplasm DNA Modification Negative Regulation Of Gene Expression U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing MRNA 3'-UTR AU-rich Region Binding Nucleus Negative Regulation Of Macromolecule Biosynthetic Process
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