EXOSC3 and PRDX1

		EXOSC3	PRDX1
Description		exosome component 3	peroxiredoxin 1
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)	Extracellular Space Nucleus Cytoplasm Cytosol Melanosome Extracellular Exosome
	Molecular Function	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding	RNA Binding Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Cadherin Binding Peroxiredoxin Activity Thioredoxin-dependent Peroxiredoxin Activity
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process DNA Metabolic Process RRNA Processing RNA Processing RNA Catabolic Process MRNA Catabolic Process Gene Expression Regulation Of Gene Expression U4 SnRNA 3'-end Processing DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Poly(A)-dependent SnoRNA 3'-end Processing	Response To Reactive Oxygen Species Skeletal System Development Response To Oxidative Stress Canonical NF-kappaB Signal Transduction Cell Population Proliferation Removal Of Superoxide Radicals Natural Killer Cell Activation Regulation Of Stress-activated MAPK Cascade Erythrocyte Homeostasis Natural Killer Cell Mediated Cytotoxicity Hydrogen Peroxide Catabolic Process Leukocyte Activation Cell Redox Homeostasis Fibroblast Proliferation Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs			Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Body mass index ( 26426971) Hemoglobin ( 32888494)
Interacting Genes		9 interacting genes: APP ATP5F1D CDK5RAP1 EXOSC4 EXOSC5 EXOSC9 KHSRP MPHOSPH6 TSR2	31 interacting genes: ABL1 ADH5 ADRB2 AXIN2 CALM1 CCR4 CDK1 CEBPA CLEC4G EGFR GAPDH IRAK1 IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 PTEN PTGER4 SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ
Entrez ID		51010	5052
HPRD ID		16220	01458
Ensembl ID		ENSG00000107371	ENSG00000117450
Uniprot IDs		Q9NQT5	A0A384NPQ2 Q06830
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P	2RII 3HY2 4XCS 7LJ1 7WET 7WEU 8X71 8X73 8Z54 8Z55 8Z56 8Z57 8Z58 9B7A
Enriched GO Terms of Interacting Partners?		Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Exoribonuclease Complex U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process RRNA Processing RNA Processing RRNA Metabolic Process SnRNA 3'-end Processing MRNA 3'-UTR AU-rich Region Binding 3'-5'-RNA Exonuclease Activity SnRNA Processing Nuclear RNA Surveillance RNA Surveillance SnRNA Metabolic Process RNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RNA 3'-end Processing Nucleobase-containing Compound Metabolic Process DNA Deamination Negative Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process Sno(s)RNA Metabolic Process MRNA Catabolic Process Nucleic Acid Metabolic Process Maturation Of 5.8S RRNA DNA Modification RNA Binding Nucleolus Response To Copper Ion RNA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Response To Other Organism MRNA Metabolic Process Negative Regulation Of Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Sebum Secreting Cell Proliferation Positive Regulation Of Translational Fidelity TRNA-2-methylthio-N(6)-dimethylallyladenosine(37) Synthase Activity Euchromatin Regulation Of Nitric Oxide Biosynthetic Process	Response To Lipid Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Intracellular Signaling Cassette Cellular Response To Oxygen-containing Compound Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Response To Stress Positive Regulation Of Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signal Transduction Protein-containing Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Gene Expression Regulation Of Signal Transduction Molecular Adaptor Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Lipid Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of DNA Metabolic Process Chromosome Organization Nucleus ERK1 And ERK2 Cascade Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Autophagy Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Response To Cytokine Leukocyte Activation Response To Peptide Negative Regulation Of TORC1 Signaling Enzyme Binding Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Leukocyte Activation Involved In Immune Response Regulation Of Macromolecule Biosynthetic Process Regulation Of Growth Cell Activation Involved In Immune Response Positive Regulation Of DNA Metabolic Process
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