EXOSC3 and ATP5F1D

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		EXOSC3	ATP5F1D
Description		exosome component 3	ATP synthase F1 subunit delta
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Proton-transporting ATP Synthase Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding	Structural Molecule Activity Protein Binding ATP Binding ADP Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process DNA Metabolic Process RRNA Processing RNA Processing RNA Catabolic Process MRNA Catabolic Process Gene Expression Regulation Of Gene Expression U4 SnRNA 3'-end Processing DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Poly(A)-dependent SnoRNA 3'-end Processing	ATP Biosynthetic Process Monoatomic Ion Transport Aerobic Respiration Proton Motive Force-driven ATP Synthesis Mitochondrial Proton-transporting ATP Synthase Complex Assembly Proton Motive Force-driven Mitochondrial ATP Synthesis Response To Copper Ion Proton Transmembrane Transport
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Formation of ATP by chemiosmotic coupling Cristae formation
Drugs			Isoflurane Desflurane
Diseases
GWAS
Interacting Genes		9 interacting genes: APP ATP5F1D CDK5RAP1 EXOSC4 EXOSC5 EXOSC9 KHSRP MPHOSPH6 TSR2	9 interacting genes: EXOSC3 KRTAP10-8 MDFI NBPF19 NOTCH2NLA SRSF11 TRIM55 TRIM63 TTN
Entrez ID		51010	513
HPRD ID		16220	04397
Ensembl ID		ENSG00000107371	ENSG00000099624
Uniprot IDs		Q9NQT5	P30049
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P	8H9F 8H9J 8H9M 8H9Q 8H9S 8H9T 8H9U 8H9V 8KHF 8KI3
Enriched GO Terms of Interacting Partners?		Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Exoribonuclease Complex U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process RRNA Processing RNA Processing RRNA Metabolic Process SnRNA 3'-end Processing MRNA 3'-UTR AU-rich Region Binding 3'-5'-RNA Exonuclease Activity SnRNA Processing Nuclear RNA Surveillance RNA Surveillance SnRNA Metabolic Process RNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RNA 3'-end Processing Nucleobase-containing Compound Metabolic Process DNA Deamination Negative Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process Sno(s)RNA Metabolic Process MRNA Catabolic Process Nucleic Acid Metabolic Process Maturation Of 5.8S RRNA DNA Modification RNA Binding Nucleolus Response To Copper Ion RNA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Response To Other Organism MRNA Metabolic Process Negative Regulation Of Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Sebum Secreting Cell Proliferation Positive Regulation Of Translational Fidelity TRNA-2-methylthio-N(6)-dimethylallyladenosine(37) Synthase Activity Euchromatin Regulation Of Nitric Oxide Biosynthetic Process	M Band
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