PIDD1 and POGZ

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PIDD1	POGZ
Description		p53-induced death domain protein 1	pogo transposable element derived with ZNF domain
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Endopeptidase Complex	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Plasma Membrane Ciliary Basal Body
	Molecular Function	Endopeptidase Activity Death Receptor Binding Protein Binding Hydrolase Activity	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Apoptotic Process DNA Damage Response Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Autoprocessing DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Mitotic Sister Chromatid Cohesion Positive Regulation Of Transcription By RNA Polymerase II Cell Division Kinetochore Assembly
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS		Breast cancer ( 29059683)	Blood trace element (Cu levels) ( 23720494) Body mass index ( 26426971) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pulse pressure ( 30578418)
Interacting Genes		17 interacting genes: AFP ATM CASP2 CCDC85B CRADD EFEMP2 FADD HSD17B14 KHDC4 MADD MAFG MDFI MTNR1B POGZ PRKDC SOX8 TEAD3	87 interacting genes: A1CF ACTMAP AGR2 ANKRD10 AOC1 APP ATXN1 BANP BOLL C10orf55 CCDC136 CDK6 CERCAM CREB1 CRX DAB1 DAZAP2 DMXL1 DTX2 EID2B EIF3F EYA2 FAM168B FCSK FHL2 FNDC3B FOSB GABPB1 GMEB2 H3-4 HGS HIVEP1 HSF2BP HSPB2 HSPB2-C11orf52 HYI JMJD7 KLHDC7B KLHL26 KRTAP3-2 KRTAP6-2 KRTAP8-1 LITAF MBLAC1 MYO1B NFYA NFYC NHLRC4 NICN1 NRF1 ODAM PFDN5 PIDD1 PLEKHB2 PLIN2 POU2AF1 POU2F1 PRR20A PRR20B PRR20C PRR20D PRR20E QRICH1 RBFOX1 RBPMS RSPH1 SP1 SP3 SP4 SPATA12 SPRYD7 STH SUMO2 TBX19 TCIRG1 TMBIM4 TSC1 UFSP1 VAV2 VEZF1 VGLL3 ZBTB24 ZNF143 ZNF410 ZNF710 ZNF76 ZXDC
Entrez ID		55367	23126
HPRD ID		11284	11445
Ensembl ID		ENSG00000177595	ENSG00000143442
Uniprot IDs		Q9HB75	A0A8V8TQ67 Q7Z3K3
PDB IDs		2OF5	2E72 2N3A 6EMP
Enriched GO Terms of Interacting Partners?		DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Endopeptidase Complex Cell Death Programmed Cell Death Signal Transduction In Response To DNA Damage DNA Damage Response, Signal Transduction By P53 Class Mediator Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Mechanical Stimulus Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death V(D)J Recombination Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II Ectopic Germ Cell Programmed Cell Death Death Receptor Binding Reproductive Process Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Involved In Cell Development Execution Phase Of Apoptosis Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of RNA Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of DNA-templated Transcription Cell Fate Commitment Cellular Developmental Process Ovulation Cycle Process Somitogenesis Peptidyl-serine Phosphorylation DNA Damage Response Somatic Cell DNA Recombination Response To Mechanical Stimulus T Cell Differentiation In Thymus Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Smooth Muscle Cell-matrix Adhesion D-threo-aldose 1-dehydrogenase Activity Thymus Development Positive Regulation Of RNA Metabolic Process Double-strand Break Repair Developmental Process Involved In Reproduction Regulation Of DNA-templated Transcription	Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Binding DNA Binding Positive Regulation Of Macromolecule Metabolic Process Nucleus DNA-binding Transcription Factor Activity Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Protein-DNA Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process CCAAT-binding Factor Complex Identical Protein Binding Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Adult Locomotory Behavior
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