PIDD1 and CASP2

Number of citations of the paper that reports this interaction (PMID 15073321)
127

Data Source:
HPRD (in vivo)

		PIDD1	CASP2
Gene Name		p53-induced death domain protein 1	caspase 2, apoptosis-related cysteine peptidase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus	Nucleus Cytoplasm Mitochondrion Cytosol Membrane
	Molecular Function	Death Receptor Binding Protein Binding	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Luteolysis Neural Retina Development Proteolysis Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Brain Development Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Processing Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Signaling Pathway
Pathways			Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway p75 NTR receptor-mediated signalling NADE modulates death signalling Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: AFP CASP2 CCDC85B CRADD EFEMP2 FADD KEAP1 MADD MAFG MDFI SOX8 TEAD3	30 interactors: ADCYAP1 BID BIRC2 CASP10 CASP14 CASP3 CASP7 CASP8 CCND3 CFLAR CRADD CSNK2A1 DCTN1 DSP EEF1A1 GOLGA3 GRB2 KPNA2 MDM2 MZB1 NLRP1 NOD1 NOL3 PIDD1 RAI1 RB1 RPL30 RXRA SUMO1 UBE2I
Entrez ID		55367	835
HPRD ID		11284	02800
Ensembl ID		ENSG00000177595	ENSG00000106144
Uniprot IDs		Q9HB75	C9JRR9 D3DXD8 D3DXD9 P42575
PDB IDs		2OF5	1PYO 2P2C 3R5J 3R6G 3R6L 3R7B 3R7N 3R7S 3RJM
Enriched GO Terms of Interacting Partners?		Cellular Response To Mechanical Stimulus Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Differentiation Response To Stimulus Reproductive Structure Development Positive Regulation Of Cellular Metabolic Process Reproductive System Development In Utero Embryonic Development Cellular Response To Stimulus Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Response To Mechanical Stimulus Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Epidermal Cell Differentiation Development Of Primary Sexual Characteristics Protein Processing Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Signaling Regulation Of Proteolysis Regulation Of Cellular Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Reproductive Process Cell Communication Regulation Of Metabolic Process Developmental Process Involved In Reproduction Regulation Of Protein Metabolic Process Neural Retina Development DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Sex Differentiation Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Proteolysis Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Chordate Embryonic Development Regulation Of Apoptotic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Epidermis Development Positive Regulation Of Metabolic Process Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Mitotic G1 DNA Damage Checkpoint Regulation Of Cell Death Apoptotic Signaling Pathway Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint	Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Peptidase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Processing Regulation Of Catalytic Activity Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Metabolic Process Response To Stress Signaling Positive Regulation Of Catalytic Activity Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Signal Transduction Viral Process Cell Communication Positive Regulation Of Hydrolase Activity Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Signal Transduction Execution Phase Of Apoptosis Positive Regulation Of Cell Death Response To Stimulus Glial Cell Apoptotic Process Protein Metabolic Process Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Intracellular Signal Transduction Regulation Of Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Tagcloud ?			amplified array athymic caspase counterparts delayed e1a emu enhances extended lymphoma maintenance mammary mmtv mycn neu neuroblastoma nude observations oncogene paraspinal predominantly ras subset surprisingly th thoracic tumorigenesis vascularized
Tagcloud (Difference) ?			amplified array athymic caspase counterparts delayed e1a emu enhances extended lymphoma maintenance mammary mmtv mycn neu neuroblastoma nude observations oncogene paraspinal predominantly ras subset surprisingly th thoracic tumorigenesis vascularized
Tagcloud (Intersection) ?