PIDD1 and MADD

Number of citations of the paper that reports this interaction (PMID 10825539)
13

Data Source:
HPRD (in vivo)

		PIDD1	MADD
Gene Name		p53-induced death domain protein 1	MAP-kinase activating death domain
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus	Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Death Receptor Binding Protein Binding	Death Receptor Binding Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Protein Kinase Activator Activity
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Activation Of MAPK Activity Cell Surface Receptor Signaling Pathway Regulation Of Rab Protein Signal Transduction Positive Regulation Of Rab GTPase Activity Regulation Of Apoptotic Process Regulation Of Cell Cycle Execution Phase Of Apoptosis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) HDL cholesterol ( 19060911) Proinsulin levels ( 21873549)
Protein-Protein Interactions		12 interactors: AFP CASP2 CCDC85B CRADD EFEMP2 FADD KEAP1 MADD MAFG MDFI SOX8 TEAD3	9 interactors: NPDC1 PIDD1 POT1 PTPRN TNFRSF10A TNFRSF10B TNFRSF1A VPS13D YWHAZ
Entrez ID		55367	8567
HPRD ID		11284	04664
Ensembl ID		ENSG00000177595	ENSG00000110514
Uniprot IDs		Q9HB75	Q8WXG6
PDB IDs		2OF5
Enriched GO Terms of Interacting Partners?		Cellular Response To Mechanical Stimulus Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Differentiation Response To Stimulus Reproductive Structure Development Positive Regulation Of Cellular Metabolic Process Reproductive System Development In Utero Embryonic Development Cellular Response To Stimulus Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Response To Mechanical Stimulus Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Epidermal Cell Differentiation Development Of Primary Sexual Characteristics Protein Processing Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Signaling Regulation Of Proteolysis Regulation Of Cellular Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Reproductive Process Cell Communication Regulation Of Metabolic Process Developmental Process Involved In Reproduction Regulation Of Protein Metabolic Process Neural Retina Development DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Sex Differentiation Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Proteolysis Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Chordate Embryonic Development Regulation Of Apoptotic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Epidermis Development Positive Regulation Of Metabolic Process Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Mitotic G1 DNA Damage Checkpoint Regulation Of Cell Death Apoptotic Signaling Pathway Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint	Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Zymogen Activation Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Cell Death Death Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Positive Regulation Of Signal Transduction Intrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Response To Mechanical Stimulus Regulation Of Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Protein Processing Regulation Of Cell Death Positive Regulation Of NIK/NF-kappaB Signaling NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Proteolysis Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Hormone Secretion Positive Regulation Of DNA Strand Elongation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Hormone Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Dense Core Granule Maturation Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Positive Regulation Of Catalytic Activity Telomere Formation Via Telomerase TRAIL-activated Apoptotic Signaling Pathway Regulation Of Proteolysis
Tagcloud ?			abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4
Tagcloud (Difference) ?			abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4
Tagcloud (Intersection) ?