PIDD1 and MADD

Number of citations: 0 (PubMedID 10825539)
Data Source: HPRD (in vivo)

		PIDD1	MADD
Name		p53-induced death domain protein 1	MAP kinase activating death domain
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Endopeptidase Complex	Cytoplasm Cytosol Plasma Membrane Membrane Axon Cell Projection
	Molecular Function	Endopeptidase Activity Death Receptor Binding Protein Binding Hydrolase Activity	Guanyl-nucleotide Exchange Factor Activity Death Receptor Binding Protein Binding Protein Kinase Activator Activity
	Biological Process	Apoptotic Process DNA Damage Response Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Autoprocessing DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Rab Protein Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Cell Cycle Execution Phase Of Apoptosis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases	None
GWAS		Breast cancer ( 29059683 )	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717 ) Autism spectrum disorder or schizophrenia ( 28540026 ) C-reactive protein levels ( 30388399 ) Chronic kidney disease ( 26831199 ) Chronotype ( 30696823 ) Corneal astigmatism ( 29422769 ) Fasting blood glucose ( 20081858 22581228 25631608 ) Fasting blood glucose (BMI interaction) ( 22581228 ) Fasting blood proinsulin levels ( 23263489 ) Fasting glucose ( 34059833 ) General factor of neuroticism ( 30867560 ) Glaucoma (primary open-angle) ( 29891935 ) Glycemic traits (pleiotropy) ( 31021400 ) HDL cholesterol ( 25961943 19060911 ) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Insulin-related traits (multivariate analysis) ( 32002517 ) Loneliness ( 29970889 ) Loneliness (MTAG) ( 29970889 ) Monocyte percentage of white cells ( 32888494 ) Neuroticism ( 29255261 ) Proinsulin levels ( 21873549 ) Refractive error ( 32231278 )
Interacting Genes		17 interacting genes: AFP ATM CASP2 CCDC85B CRADD EFEMP2 FADD HSD17B14 KHDC4 MADD MAFG MDFI MTNR1B POGZ PRKDC SOX8 TEAD3	12 interacting genes: NPDC1 PCNT PIDD1 POT1 PTPRN RB1CC1 RBM11 TNFRSF10A TNFRSF10B TNFRSF1A VPS13D YWHAZ
Entrez ID		55367	8567
HPRD ID		11284	04664
Ensembl ID		ENSG00000177595	ENSG00000110514
Uniprot IDs		Q9HB75	A0A0A0MRB5 A0A0U1RR25 A0A9L9PXF1 A0A9L9PXN0 A0A9L9PXZ0 A0A9L9PXZ3 A0A9L9PY18 A0A9L9PY22 Q8WXG6
PDB IDs		2OF5	Not available
GO Terms Enriched among Interactors		DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Endopeptidase Complex Cell Death Programmed Cell Death Signal Transduction In Response To DNA Damage DNA Damage Response, Signal Transduction By P53 Class Mediator Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Mechanical Stimulus Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death V(D)J Recombination Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II Ectopic Germ Cell Programmed Cell Death Death Receptor Binding Reproductive Process Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Involved In Cell Development Execution Phase Of Apoptosis Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of RNA Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of DNA-templated Transcription Cell Fate Commitment Cellular Developmental Process Ovulation Cycle Process Somitogenesis Peptidyl-serine Phosphorylation DNA Damage Response Somatic Cell DNA Recombination Response To Mechanical Stimulus T Cell Differentiation In Thymus Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Smooth Muscle Cell-matrix Adhesion D-threo-aldose 1-dehydrogenase Activity Thymus Development Positive Regulation Of RNA Metabolic Process Double-strand Break Repair Developmental Process Involved In Reproduction Regulation Of DNA-templated Transcription	Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Death Receptor Activity TRAIL Binding Cellular Response To Mechanical Stimulus TRAIL-activated Apoptotic Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Process Cell Death Programmed Cell Death Response To Mechanical Stimulus Activation Of Protein Kinase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death TRAIL Receptor Activity Ribophagy Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Signaling Receptor Activity Regulation Of Canonical NF-kappaB Signal Transduction Synaptic Target Recognition Positive Regulation Of Telomeric Loop Disassembly Dense Core Granule Maturation 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Endopeptidase Complex Response To Stress Secretory Granule Maturation Positive Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Telomeric D-loop Binding Telomere Assembly Protein Retention In Golgi Apparatus Cellular Response To Stress Golgi Reassembly Single-stranded Telomeric DNA Binding Positive Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Aortic Valve Development Semi-lunar Valve Development Phosphoserine Residue Binding Positive Regulation Of Kinase Activity Shelterin Complex Organelle Organization