PIDD1

Description		p53-induced death domain protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Endopeptidase Complex
	Molecular Function	Endopeptidase Activity Death Receptor Binding Protein Binding Hydrolase Activity
	Biological Process	Apoptotic Process DNA Damage Response Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Autoprocessing DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS		Breast cancer ( 29059683)
Interacting Genes		17 interacting genes: AFP ATM CASP2 CCDC85B CRADD EFEMP2 FADD HSD17B14 KHDC4 MADD MAFG MDFI MTNR1B POGZ PRKDC SOX8 TEAD3
Entrez ID		55367
HPRD ID		11284
Ensembl ID		ENSG00000177595
Uniprot IDs		Q9HB75
PDB IDs		2OF5
Enriched GO Terms of Interacting Partners?		DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Endopeptidase Complex Cell Death Programmed Cell Death Signal Transduction In Response To DNA Damage DNA Damage Response, Signal Transduction By P53 Class Mediator Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Mechanical Stimulus Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death V(D)J Recombination Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II Ectopic Germ Cell Programmed Cell Death Death Receptor Binding Reproductive Process Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Involved In Cell Development Execution Phase Of Apoptosis Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of RNA Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of DNA-templated Transcription Cell Fate Commitment Cellular Developmental Process Ovulation Cycle Process Somitogenesis Peptidyl-serine Phosphorylation DNA Damage Response Somatic Cell DNA Recombination Response To Mechanical Stimulus T Cell Differentiation In Thymus Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Smooth Muscle Cell-matrix Adhesion D-threo-aldose 1-dehydrogenase Activity Thymus Development Positive Regulation Of RNA Metabolic Process Double-strand Break Repair Developmental Process Involved In Reproduction Regulation Of DNA-templated Transcription
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