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PIDD1 and SOX8
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
PIDD1
SOX8
Description
p53-induced death domain protein 1
SRY-box transcription factor 8
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Golgi Apparatus
Cytosol
Endopeptidase Complex
Chromatin
Nucleus
Transcription Regulator Complex
Cytoplasm
Molecular Function
Endopeptidase Activity
Death Receptor Binding
Protein Binding
Hydrolase Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA-binding Transcription Factor Activity
Sequence-specific DNA Binding
DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Apoptotic Process
DNA Damage Response
Signal Transduction
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Protein Autoprocessing
DNA Damage Response, Signal Transduction By P53 Class Mediator
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
In Utero Embryonic Development
Neural Crest Cell Migration
Morphogenesis Of An Epithelium
Signal Transduction
Spermatogenesis
Peripheral Nervous System Development
Male Gonad Development
Positive Regulation Of Gene Expression
Regulation Of Hormone Levels
Positive Regulation Of Gliogenesis
Neural Crest Cell Development
Positive Regulation Of Osteoblast Proliferation
Skeletal Muscle Cell Differentiation
Negative Regulation Of Apoptotic Process
Cell Fate Commitment
Fat Cell Differentiation
Negative Regulation Of Myoblast Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Photoreceptor Cell Differentiation
Cell Maturation
Enteric Nervous System Development
Oligodendrocyte Differentiation
Sertoli Cell Development
Astrocyte Fate Commitment
Retina Development In Camera-type Eye
Retinal Rod Cell Differentiation
Adipose Tissue Development
Morphogenesis Of A Branching Epithelium
Renal Vesicle Induction
Ureter Morphogenesis
Metanephric Nephron Tubule Formation
Positive Regulation Of Kidney Development
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Pathways
TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS
Breast cancer (
29059683
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Logical memory (immediate recall) in normal cognition (
29274321
)
Multiple sclerosis (
21833088
31604244
)
Polycystic ovary syndrome (
25574032
)
Interacting Genes
17 interacting genes:
AFP
ATM
CASP2
CCDC85B
CRADD
EFEMP2
FADD
HSD17B14
KHDC4
MADD
MAFG
MDFI
MTNR1B
POGZ
PRKDC
SOX8
TEAD3
18 interacting genes:
CEBPA
DLX5
EGR2
HHEX
HOXC11
JAM2
JUN
MMP1
NOD1
NR5A1
OLIG2
PAX3
PIDD1
POU3F3
POU5F1
SP1
TCF12
UTF1
Entrez ID
55367
30812
HPRD ID
11284
16175
Ensembl ID
ENSG00000177595
ENSG00000005513
Uniprot IDs
Q9HB75
P57073
PDB IDs
2OF5
Enriched GO Terms of Interacting Partners
?
DNA-dependent Protein Kinase Activity
Histone H2AXS139 Kinase Activity
Endopeptidase Complex
Cell Death
Programmed Cell Death
Signal Transduction In Response To DNA Damage
DNA Damage Response, Signal Transduction By P53 Class Mediator
Apoptotic Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Cellular Response To Mechanical Stimulus
Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
V(D)J Recombination
Signal Transduction By P53 Class Mediator
Positive Regulation Of Transcription By RNA Polymerase II
Ectopic Germ Cell Programmed Cell Death
Death Receptor Binding
Reproductive Process
Extrinsic Apoptotic Signaling Pathway
Programmed Cell Death Involved In Cell Development
Execution Phase Of Apoptosis
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of RNA Biosynthetic Process
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of DNA-templated Transcription
Cell Fate Commitment
Cellular Developmental Process
Ovulation Cycle Process
Somitogenesis
Peptidyl-serine Phosphorylation
DNA Damage Response
Somatic Cell DNA Recombination
Response To Mechanical Stimulus
T Cell Differentiation In Thymus
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation
Positive Regulation Of Smooth Muscle Cell-matrix Adhesion
D-threo-aldose 1-dehydrogenase Activity
Thymus Development
Positive Regulation Of RNA Metabolic Process
Double-strand Break Repair
Developmental Process Involved In Reproduction
Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
HMG Box Domain Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Chromatin
Positive Regulation Of RNA Metabolic Process
Sequence-specific Double-stranded DNA Binding
Transcription Cis-regulatory Region Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Factor Activity
Positive Regulation Of Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Sequence-specific DNA Binding
Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Animal Organ Development
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
RNA Polymerase II Transcription Regulator Complex
Response To Gonadotropin-releasing Hormone
Positive Regulation Of Developmental Process
Cellular Developmental Process
Regulation Of Metabolic Process
Developmental Process
Regulation Of Multicellular Organismal Process
Regulation Of Developmental Process
System Development
CAMP Response Element Binding
Nucleus
Transcription Regulator Complex
Positive Regulation Of Gene Expression
Positive Regulation Of Multicellular Organismal Process
Host-mediated Activation Of Viral Transcription
Positive Regulation Of Canonical Wnt Signaling Pathway
Nervous System Development
Cell Differentiation
Organ Induction
Double-stranded DNA Binding
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