EPS15L1 and STON2

Number of citations of the paper that reports this interaction (PMID 11381094)
45

Data Source:
HPRD (two hybrid)

		EPS15L1	STON2
Gene Name		epidermal growth factor receptor pathway substrate 15-like 1	stonin 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Coated Pit Membrane	Nucleolus Cytoplasm Synaptic Vesicle Cell Junction Clathrin Adaptor Complex Clathrin-coated Vesicle Neuron Projection
	Molecular Function	Calcium Ion Binding Protein Binding	Protein Binding
	Biological Process	Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Hematopoietic Progenitor Cell Differentiation Intracellular Protein Transport Regulation Of Endocytosis Synaptic Vesicle Endocytosis
Pathways		Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS		Multiple sclerosis ( 22190364) White blood cell count ( 21738480) White matter integrity ( 23218918)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: AGFG1 AGFG2 EPN1 GNG5 ITSN1 ITSN2 STON2 TRAPPC2B	6 interactors: AP2M1 EPS15 EPS15L1 ITSN1 SYT1 SYT2
Entrez ID		58513	85439
HPRD ID		09445	10531
Ensembl ID		ENSG00000127527	ENSG00000140022
Uniprot IDs		Q9UBC2	Q8WXE9
PDB IDs			2JXC
Enriched GO Terms of Interacting Partners?		Regulation Of Ras GTPase Activity Endocytosis Regulation Of Ras Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Positive Regulation Of Hydrolase Activity Regulation Of ARF GTPase Activity Regulation Of Signal Transduction Regulation Of ARF Protein Signal Transduction Vesicle-mediated Transport Synaptic Vesicle Transport Synaptic Transmission Positive Regulation Of Catalytic Activity Regulation Of Signaling Regulation Of Intracellular Signal Transduction Establishment Of Vesicle Localization Vesicle Localization Cell-cell Signaling Positive Regulation Of Rho GTPase Activity Regulation Of Rho GTPase Activity Regulation Of Catalytic Activity Establishment Of Organelle Localization Regulation Of Rho Protein Signal Transduction Acrosome Assembly Intermediate Filament Organization Transport Organelle Localization Positive Regulation Of Ras GTPase Activity Regulation Of Cellular Process Spermatid Nucleus Differentiation Positive Regulation Of Metabolic Process	Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transport Regulation Of Signaling Ephrin Receptor Signaling Pathway Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Synaptic Transmission Synaptic Vesicle Transport Establishment Of Localization In Cell Cell-cell Signaling Establishment Of Vesicle Localization Pathogenesis Vesicle Localization Neurotrophin TRK Receptor Signaling Pathway Calcium Ion-dependent Exocytosis Of Neurotransmitter Neurotrophin Signaling Pathway Cellular Localization Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Establishment Of Organelle Localization Detection Of Calcium Ion Positive Regulation Of Calcium Ion-dependent Exocytosis Cell Surface Receptor Signaling Pathway Signaling Axon Guidance Cell Communication Golgi To Endosome Transport Organelle Localization Positive Regulation Of Vesicle Fusion Negative Regulation Of Protein Localization To Plasma Membrane Endocytic Recycling Glutamate Secretion Regulation Of Defense Response To Virus By Virus Axonogenesis Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Vesicle Fusion Chemotaxis Response To Growth Factor Clathrin Coat Assembly
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