EPS15L1 and TRAPPC2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		EPS15L1	TRAPPC2
Name		epidermal growth factor receptor pathway substrate 15 like 1	trafficking protein particle complex subunit 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Coat Of Coated Pit Presynapse	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol TRAPP Complex Perinuclear Region Of Cytoplasm TRAPPII Protein Complex TRAPPIII Protein Complex
	Molecular Function	Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Cadherin Binding Metal Ion Binding	Protein Binding Transmembrane Transporter Binding
	Biological Process	Endocytosis Endosomal Transport Synaptic Vesicle Endocytosis	Skeletal System Development Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Coating Vesicle-mediated Transport COPII Vesicle Coating Vesicle Tethering
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs
Diseases		None	Spondyloepiphyseal dysplasia tarda
GWAS		Basophil count ( 32888494 ) Body size at age 10 ( 32376654 ) Eosinophil count ( 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 32888494 ) Lymphocyte count ( 32888494 27863252 29403010 ) Lymphocyte percentage of white cells ( 32888494 27863252 ) Monocyte percentage of white cells ( 32888494 27863252 ) Multiple sclerosis ( 22190364 31604244 24076602 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 27863252 32888494 ) White blood cell count ( 27863252 21738480 32888494 ) White matter integrity ( 23218918 )	No GWAS studies recorded
Interacting Genes		13 interacting genes: ABL1 AGFG1 AGFG2 EPN1 FCHO1 FCHO2 GNG5 LRRC7 SIM2 STON2 TRAPPC2 TRAPPC2B UBC	34 interacting genes: ABRA CLIC1 CLIC2 DAPK1 EIF3C ENO1 ENO3 EPS15L1 HLA-E INCA1 KCTD1 MBD3L1 MFHAS1 NICN1 NME4 NR5A1 PITX1 PYGM REPS1 SLC25A35 SNAPC5 SNCA TEPSIN TRAPPC3 TRAPPC3L TRAPPC4 TRAPPC6A TRAPPC6B TRAPPC9 UQCC2 ZBTB38 ZNF438 ZNF655 ZRANB1
Entrez ID		58513	6399
HPRD ID		09445	02189
Ensembl ID		ENSG00000127527	ENSG00000196459
Uniprot IDs		A0AAQ5BI61 Q9UBC2	P0DI81 P0DI82 Q6IBE5
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Vesicle-mediated Transport Clathrin-dependent Endocytosis Endocytosis Spermatid Nucleus Differentiation Clathrin-coated Pit TRAPPII Protein Complex TRAPPIII Protein Complex Establishment Of Localization In Cell Import Into Cell TRAPP Complex Vesicle Organization Clathrin Coat Assembly COPII Vesicle Coating Acrosome Assembly Vesicle Tethering Receptor-mediated Endocytosis Vesicle Coating Synaptic Vesicle Endocytosis Presynaptic Endocytosis Protein Localization To Cytoplasmic Microtubule Plus-end Cellular Component Assembly Secretory Granule Organization Transitional One Stage B Cell Differentiation Podocyte Apoptotic Process DN4 Thymocyte Differentiation Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Protein-containing Complex Assembly Cytoplasm Intermediate Filament Organization Endoplasmic Reticulum-Golgi Intermediate Compartment Clathrin-coated Vesicle Nicotinate-nucleotide Adenylyltransferase Activity Protein Localization To Microtubule Plus-end Intermediate Filament Cytoskeleton Organization Nucleus Organization Intermediate Filament-based Process Vesicle-mediated Transport In Synapse Protein-containing Complex Organization Microspike Assembly B-1 B Cell Homeostasis T Cell Receptor Signaling Pathway Positive Regulation Of Establishment Of T Cell Polarity Neuropilin Signaling Pathway	TRAPP Complex Vesicle Tethering TRAPPII Protein Complex Vesicle Coating Endoplasmic Reticulum To Golgi Vesicle-mediated Transport TRAPPIII Protein Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity COPII Vesicle Coating Golgi Vesicle Transport Protein Binding Cis-Golgi Network Membrane Vesicle-mediated Transport Vesicle Organization Intracellular Transport Establishment Of Localization In Cell