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EPS15L1 and GNG5
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
EPS15L1
GNG5
Gene Name
epidermal growth factor receptor pathway substrate 15-like 1
guanine nucleotide binding protein (G protein), gamma 5
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Plasma Membrane
Coated Pit
Membrane
Heterotrimeric G-protein Complex
Plasma Membrane
Membrane
Extracellular Vesicular Exosome
Molecular Function
Calcium Ion Binding
Protein Binding
GTPase Activity
Signal Transducer Activity
PDZ Domain Binding
Biological Process
Endocytosis
Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Energy Reserve Metabolic Process
Signal Transduction
G-protein Coupled Receptor Signaling Pathway
Synaptic Transmission
Small Molecule Metabolic Process
Cellular Response To Glucagon Stimulus
Pathways
Signaling by EGFR
EGFR downregulation
Signaling by EGFR in Cancer
Signaling by Ligand-Responsive EGFR Variants in Cancer
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by EGFRvIII in Cancer
Signaling by GPCR
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 1
Integration of energy metabolism
G alpha (s) signalling events
Activation of GABAB receptors
Glucagon-type ligand receptors
G beta:gamma signalling through PLC beta
Signaling by Wnt
Metabolic disorders of biological oxidation enzymes
G protein gated Potassium channels
Gastrin-CREB signalling pathway via PKC and MAPK
Thromboxane signalling through TP receptor
G alpha (z) signalling events
G alpha (i) signalling events
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
ADP signalling through P2Y purinoceptor 12
Glucagon signaling in metabolic regulation
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Inwardly rectifying K+ channels
G-protein beta:gamma signalling
Opioid Signalling
Activation of Kainate Receptors upon glutamate binding
Aquaporin-mediated transport
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (q) signalling events
GPCR downstream signaling
Platelet homeostasis
Platelet activation, signaling and aggregation
Transmission across Chemical Synapses
G alpha (q) signalling events
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signal amplification
Potassium Channels
G beta:gamma signalling through PI3Kgamma
G alpha (12/13) signalling events
Class B/2 (Secretin family receptors)
Prostacyclin signalling through prostacyclin receptor
GABA B receptor activation
GABA receptor activation
Activation of G protein gated Potassium channels
Vasopressin regulates renal water homeostasis via Aquaporins
Regulation of insulin secretion
GPCR ligand binding
beta-catenin independent WNT signaling
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Ca2+ pathway
G-protein activation
Drugs
Diseases
GWAS
Multiple sclerosis (
22190364
)
White blood cell count (
21738480
)
White matter integrity (
23218918
)
Protein-Protein Interactions
8 interactors:
AGFG1
AGFG2
EPN1
GNG5
ITSN1
ITSN2
STON2
TRAPPC2B
12 interactors:
AMOTL2
EPS15L1
GNB1
GNB2
GNB3
GNB4
GNB5
GOLGA2
KRT31
KRT40
MDFI
TRAF1
Entrez ID
58513
2787
HPRD ID
09445
11865
Ensembl ID
ENSG00000127527
ENSG00000174021
Uniprot IDs
Q9UBC2
P63218
PDB IDs
Enriched GO Terms of Interacting Partners
?
Regulation Of Ras GTPase Activity
Endocytosis
Regulation Of Ras Protein Signal Transduction
Positive Regulation Of GTPase Activity
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of GTPase Activity
Synaptic Vesicle Endocytosis
Synaptic Vesicle Recycling
Positive Regulation Of Hydrolase Activity
Regulation Of ARF GTPase Activity
Regulation Of Signal Transduction
Regulation Of ARF Protein Signal Transduction
Vesicle-mediated Transport
Synaptic Vesicle Transport
Synaptic Transmission
Positive Regulation Of Catalytic Activity
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Establishment Of Vesicle Localization
Vesicle Localization
Cell-cell Signaling
Positive Regulation Of Rho GTPase Activity
Regulation Of Rho GTPase Activity
Regulation Of Catalytic Activity
Establishment Of Organelle Localization
Regulation Of Rho Protein Signal Transduction
Acrosome Assembly
Intermediate Filament Organization
Transport
Organelle Localization
Positive Regulation Of Ras GTPase Activity
Regulation Of Cellular Process
Spermatid Nucleus Differentiation
Positive Regulation Of Metabolic Process
Cellular Response To Glucagon Stimulus
Response To Glucagon
Energy Reserve Metabolic Process
Energy Derivation By Oxidation Of Organic Compounds
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Peptide
Generation Of Precursor Metabolites And Energy
Response To Peptide Hormone
Signal Transduction
Cellular Response To Organonitrogen Compound
Response To Peptide
Regulation Of Rhodopsin Mediated Signaling Pathway
Signaling
Rhodopsin Mediated Signaling Pathway
Cell Communication
Cellular Response To Hormone Stimulus
Cellular Response To Stimulus
Response To Organonitrogen Compound
Phototransduction, Visible Light
Response To Hormone
Detection Of Visible Light
Cellular Response To Light Stimulus
Phototransduction
Negative Regulation Of Binding
Detection Of Light Stimulus
Cell Surface Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway
Response To Stimulus
Cellular Response To Radiation
Synaptic Transmission
Negative Regulation Of Voltage-gated Calcium Channel Activity
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Detection Of Abiotic Stimulus
Cardiac Muscle Cell Apoptotic Process
Muscle Cell Apoptotic Process
Oxidation-reduction Process
Regulation Of Signal Transduction
Regulation Of Binding
Cellular Response To Prostaglandin E Stimulus
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Cell-cell Signaling
Cellular Response To Organic Substance
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Trophoblast Giant Cell Differentiation
Regulation Of Signaling
Cellular Response To Prostaglandin Stimulus
Response To Prostaglandin E
Negative Regulation Of Cation Channel Activity
Regulation Of Voltage-gated Calcium Channel Activity
Tagcloud
?
adcy8
adcy9
br1
br2
consisted
disturbance
endometrial
endometrium
eventually
fos
g2
g3
gnb1
gng11
gng12
kinin
kinins
kras
map2k2
mapk1
microarrays
mitogenic
oligonucleotide
plcb4
prkacb
prkar1a
prkca
reaching
u133a
Tagcloud (Difference)
?
adcy8
adcy9
br1
br2
consisted
disturbance
endometrial
endometrium
eventually
fos
g2
g3
gnb1
gng11
gng12
kinin
kinins
kras
map2k2
mapk1
microarrays
mitogenic
oligonucleotide
plcb4
prkacb
prkar1a
prkca
reaching
u133a
Tagcloud (Intersection)
?